Assessing the mechanisms and dynamics of myelination in the brain

这个项目有望通过揭示髓鞘可塑性如何对经验做出反应来优化大脑功能，从而加深我们对大脑可塑性的理解。该项目使用了一种融合了动物研究、数学建模和计算神经科学的多学科方法，试图通过一种全新的集成细胞到系统的方法来重新定义我们对髓鞘重塑的理解。预期的结果是揭示髓鞘形成如何在整个生命过程中受到神经活动的动态调节的基础知识。这可能会改变目前对神经可塑性的理解，有助于未来制定改善大脑健康的策略。

This project is expected to refine our understanding of brain plasticity by revealing how myelin plasticity optimises brain function in response to experience. Using a multidisciplinary approach incorporating animal studies, mathematical modelling and computational neuroscience, the project seeks to redefine our understanding of myelin remodelling using an entirely new integrated cell-to-system approach. The expected outcome is fundamental knowledge revealing how myelination is dynamically regulated by neural activity throughout life. This may transform current understanding of neuroplasticity that could aid in the future development of strategies to improve brain health.