Assessing the mechanisms and dynamics of myelination in the brain

评估大脑髓鞘形成的机制和动态

• 批准号: FT150100207
• 负责人: Dr Tobias Merson
• 金额: $ 47.74万
• 依托单位: Monash University
• 依托单位国家: 澳大利亚
• 项目类别: ARC Future Fellowships
• 财政年份: 2016
• 资助国家: 澳大利亚
• 起止时间: 2016-02-01 至 2020-01-31
• 项目状态: 已结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/FT150100207
• 关键词: Assessing; mechanisms; dynamics; myelination; brain

This project is expected to refine our understanding of brain plasticity by revealing how myelin plasticity optimises brain function in response to experience. Using a multidisciplinary approach incorporating animal studies, mathematical modelling and computational neuroscience, the project seeks to redefine our understanding of myelin remodelling using an entirely new integrated cell-to-system approach. The expected outcome is fundamental knowledge revealing how myelination is dynamically regulated by neural activity throughout life. This may transform current understanding of neuroplasticity that could aid in the future development of strategies to improve brain health.

该项目有望通过揭示髓鞘可塑性如何优化大脑功能来改善我们对大脑可塑性的理解。该项目采用多学科方法，结合动物研究，数学建模和计算神经科学，旨在使用全新的综合细胞到系统方法重新定义我们对髓鞘重塑的理解。预期的结果是揭示髓鞘形成如何在整个生命过程中受到神经活动的动态调节的基础知识。这可能会改变目前对神经可塑性的理解，有助于未来制定改善大脑健康的策略。