Investigating mechanisms of axonal pathology following oligodendrocyte apoptosis: avenues for neuroprotection in early MS

研究少突胶质细胞凋亡后轴突病理机制：早期多发性硬化症的神经保护途径

• 批准号: nhmrc : 1066199
• 负责人: Dr Tobias Merson
• 金额: $ 45.22万
• 依托单位: The University of Melbourne
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2014
• 资助国家: 澳大利亚
• 起止时间: 2014-01-01 至 2016-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/investigating-mechanisms-axonal-early-ms/455224
• 关键词: Investigating; mechanisms; axonal; pathology; following

Recent research suggests that Multiple Sclerosis could first be triggered by the death of a type of brain cell called an oligodendrocyte. These cells insulate nerve cells in the brain which help them function normally. We will test the idea that death of oligodendrocytes impairs nerve cell function by causing inflammation and by depriving nerve cells of energy. We will determine whether preventing inflammation and feeding the nerve cells an alternative source of energy can restore normal function.

最近的研究表明，多发性硬化症可能首先是由一种叫做少突胶质细胞的脑细胞死亡引发的。这些细胞隔离大脑中的神经细胞，帮助它们正常运作。我们将测试少突胶质细胞的死亡通过引起炎症和剥夺神经细胞的能量来损害神经细胞功能的想法。我们将确定预防炎症和为神经细胞提供替代能源是否能恢复正常功能。