Kinematic Modeling of Asymmetric Vocal Fold Vibration

非对称声带振动的运动学建模

• 批准号: 8059929
• 负责人: Robin Amy Samlan
• 金额: $ 4.03万
• 依托单位: UNIVERSITY OF ARIZONA
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-08-02 至 2012-08-01
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8059929
• 关键词: Acoustics; Address; Affect; Airway Resistance; Area; Behavioral; Characteristics; Clergy; Clinical; Clinical assessments; Collection; Coupled; Databases; Dysphonia; Educational process of instructing; Evaluation; Frequencies; Goals; Human; Image; Impairment; Individual; Larynx; Law Enforcement; Lead; Left; Measurement; Measures; Medial; Medicine; Military Personnel; Modeling; Modification; Motion; Movement; Nodal; Operative Surgical Procedures; Output; Patients; Pattern; Perception; Phase; Production; Public Health; Reporting; Research; Secondary to; Severities; Shapes; Signal Transduction; Simulate; Source; Specific qualifier value; Speech; Structure; Surface; System; Testing; Trachea; Variant; Voice; Voice Disorders; Voice Quality; Withdrawal; Work; base; constriction; design; human subject; in vivo; indexing; kinematics; pressure; public health relevance; research study; simulation; social; vibration; vocal cord

DESCRIPTION (provided by applicant): The goal of this project is to develop a clearer understanding of how structural and vibratory asymmetry of the vocal folds affects both clinical measures of vocal function and severity ratings of dysphonia. Such asymmetries are key features underlying many voice disorders, including unilateral vocal fold motion impairment (VFMI), and likely contribute to the perception of breathy voice quality. Clinical voice evaluation and management are based in understanding how vocal fold vibration patterns are related to vocal function measures and perception. Determining how specific asymmetries contribute to the vocal output, however, is limited in human subjects by difficulty imaging the three-dimensional movement characteristics of vocal fold vibration, inability to systematically vary individual components of vibration, and challenges of separating the glottal source (i.e., vocal fold vibration) from filter (i.e., vocal tract) characteristics of aerodynamic and acoustic signals. Delineating these causal relationships can immediately impact the clinical use and interpretation of vocal function measures and treatment decisions for patients with breathy voice secondary to VFMI. The approach for this research is to use a kinematic model of vocal fold vibration that will allow for differential left/right control of vocal fold adduction, medial surface bulging, vibratory nodal point, phase, and fundamental frequency. The vocal fold model will be coupled to a comprehensive model of speech production, with which glottal area, vocal fold contact area, glottal airflow and output pressure can be simulated as if they were produced by a human talker. The inclusion of a trachea and vocal tract in the system allows for additional testing of the effect of airspace on the resulting output signals. For this project, the vocal fold structure and vibratory parameters selected for systematic modification will be consistent with changes reported in VFMI, and vocal fold and vocal tract changes occurring with surgical and behavioral management will be tested. The research will be guided by three hypotheses: 1) the effects of structural and vibratory asymmetry of the vocal folds can be characterized with a set of clinically-feasible acoustic and aerodynamic measures of vocal function, 2) the degree of structural and vibratory asymmetry will be directly related to severity ratings of dysphonia, and 3) constriction of the epilaryngeal section of the supraglottal vocal tract will decrease the degree of dysphonia registered both by vocal function measures and perceptually-based severity ratings. Three specific aims are designed to address these hypotheses: 1) To generate a database of simulated signals based on 47 combinations of asymmetric settings for vocal fold adduction, medial surface bulging, vibratory nodal point, phase, and fundamental frequency. The simulations will be repeated for the vowels /a/, /i/, /u/, and /ae/ and for a constricted epilarynx. 2) To measure, from each collection of signals generated in Aim 1, a battery of clinically-feasible kinematic, aerodynamic, and acoustic measures. 3) To conduct perceptual experiments that assess the severity of the dysphonia represented by the signals generated in Aim 1. PUBLIC HEALTH RELEVANCE: Vocal fold motion impairment with asymmetric vocal fold vibration leads to a breathy, weak voice, which is undesirable for people in many professions such as teaching, law enforcement, clergy, medicine, or the military. Breathy voice caused by asymmetric vocal fold vibration becomes a public health concern when it interferes with an individual's ability to communicate at work and leads to withdrawal from social situations. Better understanding of the how specific asymmetries contribute to voice quality will lead to more efficient evaluation and treatment.

描述(由申请者提供)：本项目的目标是更清楚地了解声带的结构和振动不对称如何影响发声功能的临床测量和发音困难的严重程度。这种不对称是许多声音障碍的关键特征，包括单侧声带运动障碍(VFMI)，并可能有助于感觉到呼吸的声音质量。临床嗓音评估和管理的基础是了解声带振动模式与发声功能、测量和知觉的关系。然而，在人类受试者中，由于难以成像声带振动的三维运动特征、无法系统地改变振动的单个分量、以及将声门源(即声带振动)与空气动力学和声学信号的过滤器(即声道)特征分离的挑战，确定特定的不对称对声音输出的贡献是有限的。描述这些因果关系可以立即影响发声功能测量的临床使用和解释，以及继发于VFMI的喘息音患者的治疗决策。这项研究的方法是使用声带振动的运动学模型，该模型将允许对声带内收、内侧表面鼓起、振动结点、相位和基频进行不同的左/右控制。声带模型将与语音产生的综合模型相耦合，利用该模型可以模拟声门面积、声带接触面积、声门气流和输出压力，就像它们是由人类说话者产生的一样。在系统中包括气管和声道，可以对空域对结果输出信号的影响进行额外的测试。在这个项目中，选择用于系统修改的声带结构和振动参数将与VFMI中报告的变化保持一致，并将测试手术和行为管理所发生的声带和声道变化。这项研究将以三个假设为指导：1)声带结构和振动不对称的影响可以用一套临床上可行的发声功能声学和空气动力学测量来表征；2)结构和振动不对称的程度将直接与发音困难的严重程度有关；3)声门上声道的咽旁部分收缩将降低通过发声功能测量和基于感知的严重程度所记录的发音困难的程度。设计了三个特定的目标来解决这些假设：1)基于声带内收、内侧表面鼓起、振动结点、相位和基频的47种不对称设置的组合来生成模拟信号的数据库。将对元音/a/、/i/、/u/和/ae/以及收紧的外咽音重复模拟。2)从AIM 1产生的每个信号集合中测量临床上可行的运动学、空气动力学和声学测量。3)进行知觉实验，评估目标1中产生的信号所代表的发音困难的严重程度。 与公共健康相关：声带运动障碍与声带振动不对称会导致喘息、微弱的声音，这对许多职业的人来说都是不可取的，如教学、执法、神职人员、医学或军队。当不对称声带振动引起的喘息声干扰个人在工作中的沟通能力并导致退出社交场合时，它就成为一个公共卫生问题。更好地了解特定的不对称对语音质量的影响将导致更有效的评估和治疗。