Kinematic Modeling of Asymmetric Vocal Fold Vibration

非对称声带振动的运动学建模

• 批准号: 8123324
• 负责人: Robin Amy Samlan
• 金额: $ 4.07万
• 依托单位: UNIVERSITY OF ARIZONA
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-08-02 至 2012-08-01
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8123324
• 关键词: Acoustics; Address; Affect; Airway Resistance; Area; Behavioral; Characteristics; Clergy; Clinical; Clinical assessments; Collection; Coupled; Databases; Dysphonia; Educational process of instructing; Evaluation; Frequencies; Goals; Human; Image; Impairment; Individual; Larynx; Law Enforcement; Lead; Left; Measurement; Measures; Medial; Medicine; Military Personnel; Modeling; Modification; Motion; Movement; Nodal; Operative Surgical Procedures; Output; Patients; Pattern; Perception; Phase; Production; Public Health; Reporting; Research; Secondary to; Severities; Shapes; Signal Transduction; Simulate; Source; Specific qualifier value; Speech; Structure; Surface; System; Testing; Trachea; Variant; Voice; Voice Disorders; Voice Quality; Withdrawal; Work; base; constriction; design; human subject; in vivo; indexing; kinematics; pressure; public health relevance; research study; simulation; social; vibration; vocal cord

DESCRIPTION (provided by applicant): The goal of this project is to develop a clearer understanding of how structural and vibratory asymmetry of the vocal folds affects both clinical measures of vocal function and severity ratings of dysphonia. Such asymmetries are key features underlying many voice disorders, including unilateral vocal fold motion impairment (VFMI), and likely contribute to the perception of breathy voice quality. Clinical voice evaluation and management are based in understanding how vocal fold vibration patterns are related to vocal function measures and perception. Determining how specific asymmetries contribute to the vocal output, however, is limited in human subjects by difficulty imaging the three-dimensional movement characteristics of vocal fold vibration, inability to systematically vary individual components of vibration, and challenges of separating the glottal source (i.e., vocal fold vibration) from filter (i.e., vocal tract) characteristics of aerodynamic and acoustic signals. Delineating these causal relationships can immediately impact the clinical use and interpretation of vocal function measures and treatment decisions for patients with breathy voice secondary to VFMI. The approach for this research is to use a kinematic model of vocal fold vibration that will allow for differential left/right control of vocal fold adduction, medial surface bulging, vibratory nodal point, phase, and fundamental frequency. The vocal fold model will be coupled to a comprehensive model of speech production, with which glottal area, vocal fold contact area, glottal airflow and output pressure can be simulated as if they were produced by a human talker. The inclusion of a trachea and vocal tract in the system allows for additional testing of the effect of airspace on the resulting output signals. For this project, the vocal fold structure and vibratory parameters selected for systematic modification will be consistent with changes reported in VFMI, and vocal fold and vocal tract changes occurring with surgical and behavioral management will be tested. The research will be guided by three hypotheses: 1) the effects of structural and vibratory asymmetry of the vocal folds can be characterized with a set of clinically-feasible acoustic and aerodynamic measures of vocal function, 2) the degree of structural and vibratory asymmetry will be directly related to severity ratings of dysphonia, and 3) constriction of the epilaryngeal section of the supraglottal vocal tract will decrease the degree of dysphonia registered both by vocal function measures and perceptually-based severity ratings. Three specific aims are designed to address these hypotheses: 1) To generate a database of simulated signals based on 47 combinations of asymmetric settings for vocal fold adduction, medial surface bulging, vibratory nodal point, phase, and fundamental frequency. The simulations will be repeated for the vowels /a/, /i/, /u/, and /ae/ and for a constricted epilarynx. 2) To measure, from each collection of signals generated in Aim 1, a battery of clinically-feasible kinematic, aerodynamic, and acoustic measures. 3) To conduct perceptual experiments that assess the severity of the dysphonia represented by the signals generated in Aim 1. PUBLIC HEALTH RELEVANCE: Vocal fold motion impairment with asymmetric vocal fold vibration leads to a breathy, weak voice, which is undesirable for people in many professions such as teaching, law enforcement, clergy, medicine, or the military. Breathy voice caused by asymmetric vocal fold vibration becomes a public health concern when it interferes with an individual's ability to communicate at work and leads to withdrawal from social situations. Better understanding of the how specific asymmetries contribute to voice quality will lead to more efficient evaluation and treatment.

描述（由申请人提供）：本项目的目标是更清楚地了解声带的结构和振动不对称如何影响发声功能的临床测量和发声障碍的严重程度评级。这种不对称性是许多语音障碍（包括单侧声带运动障碍（VFMI））的关键特征，并可能导致呼吸声质量的感知。临床语音评估和管理的基础是了解声带振动模式如何与声乐功能的措施和看法。然而，确定特定的不对称性如何对声音输出做出贡献在人类受试者中受到限制，因为难以对声带振动的三维运动特性进行成像，不能系统地改变振动的各个分量，以及分离声门源（即，声带振动）从滤波器（即，声道）空气动力学和声学信号的特性。描述这些因果关系可以立即影响VFMI继发呼吸音患者的发声功能测量和治疗决策的临床使用和解释。 这项研究的方法是使用声带振动的运动学模型，将允许差分左/右控制声带内收，内侧表面隆起，振动节点，相位和基频。声带模型将耦合到语音产生的综合模型，通过该模型，可以模拟声门面积、声带接触面积、声门气流和输出压力，就像它们是由人类说话者产生的一样。在系统中包括气管和声道允许额外测试空域对所得到的输出信号的影响。对于本项目，选择进行系统修改的声褶结构和振动参数将与VFMI中报告的变化一致，并将测试手术和行为管理中发生的声褶和声道变化。 本研究将以三个假设为指导：1）声带的结构和振动不对称性的影响可以用一组临床上可行的声音和空气动力学的发声功能测量来表征，2）结构和振动不对称性的程度将直接与发声障碍的严重程度等级相关，和3）声门上声道的喉外段的收缩将降低通过发声功能测量和基于感知的严重性等级记录的发声障碍的程度。设计了三个具体目标来解决这些假设：1）基于声带内收、内侧表面隆起、振动节点、相位和基频的47种非对称设置组合来生成模拟信号的数据库。将针对元音/a/、/i/、/u/和/ae/以及狭窄的喉上肌重复模拟。2)从目标1中生成的每个信号集合中测量一组临床可行的运动学、空气动力学和声学测量。3)进行感知实验，评估目标1中产生的信号所代表的发音障碍的严重程度。 公共卫生相关性：具有不对称声带振动的声带运动损伤导致呼吸微弱的声音，这对于许多职业如教学、执法、神职人员、医学或军事的人来说是不期望的。由不对称声带振动引起的呼吸声成为一个公共卫生问题，当它干扰个人在工作中沟通的能力，并导致退出社交场合。更好地理解特定的不对称性如何影响语音质量将导致更有效的评估和治疗。