Administrative Core

引言 第6节详细介绍了管理核心的任务、执行这些任务的计划和指标 用于评估已实施计划的成功程度。还介绍了成员资格要求和 增加或删除成员的程序，CEG结构已采取的变化 地点，包括更改调查员成员，以重点小组取代研究核心，以及 设施核心的变化，这在第7节(第667页)中有更详细的说明。详细 职业发展计划的实施将在第4节(第624页)中讨论。委员会的报告 试点项目计划和在该计划中实施的更改的说明详见第8页的第8节 754.下文说明中央支助小组外联部分的终止情况。 环境遗传学中心的首要目标是改善人类健康 通过将基础、遗传学、临床和流行病学研究融入临床实践 和公共卫生倡议。因此，落实这些目标构成了 管理核心，它将有效地管理中心，以实现这些目标，创建 将对图1产生影响的居民和设施的社区 行政核心将做到这一点，不仅是通过监督组织、预算和 报告赠款的各个方面，但最重要的是，通过为 作为一个整体，中心的科学和方案活动。 主任(Ho)、副主任(Puga)和副主任(Lanphear和Nebert)负责 负责中心活动的全面协调和监督。它们既提供科学领导，又提供财政支持 中心的管理。 为履行这些职责，他们得到由以下机构组成的内部咨询委员会的协助 焦点小组重点调查员(见下面的图3)、设施核心负责人(图1带*)、选定的CEG 成员和其他大学教职员工，为大学内的相关项目提供链接。这个 IAC的董事和选定的成员组成一个小组委员会，该小组委员会将称为执行委员会 委员会审议阶段。该委员会每月召开会议，协助董事监督 CEG的日常运行。通过纳入精英理事会，扩大了咨询基础 UC/CCHMC专家，由UC/CCHMC研究和管理专家组成的杰出小组 (毕晓普、布罗德里克、库拉纳-好时和斯坦布鲁克)，以及外部咨询委员会(EAC)， 由一群杰出的非加州大学科学家组成，他们提供强大的咨询作用，专注于 关于人类遗传学和环境健康以及在大环境管理方面的丰富经验 多学科项目。项目经理协助中心的日常管理， 财务监测、报告、组织小组会议、记录保存以及组织和规划 中心活动、研讨会和座谈会。项目经理由兼职人员协助(30%的工作量) 授权管理员(也称为财务管理员)，负责监督所有与授权相关的财务和 与大学内外中心活动相关的合规问题。项目经理在 负责CEG界面通讯半年一次的制作和CEG的例行更新 网站内容，由协理主任Daniel Nebert博士监督。 核心为格雷斯博士领导的职业发展计划(CDP)提供行政支持 莱马斯特和Daniel Woo(见第624页第4节)和由协调的试点项目计划(PPP) PPP副主任Daniel Nebert博士和综合卫生副主任Dr。 布鲁斯·兰菲尔。在这次重新提交中提出了三个设施和服务(F&S)核心 他们都向行政核心汇报工作，并将接受业绩评估，非正式和 来自执行委员会、机构间咨询委员会精英理事会和选委会的正式投入和咨询意见，它们举行会议 在不同的频率(下面详细描述)。F&S三核是一体化的技术支撑 核心(ITS，第7.1节，第667页)、综合保健服务核心(第7.1节，第694页)和 生物信息学核心(第721页7.3节)。中心研究得到了F&A核心和PPP的支持 奖励，以及由行政核心组织的培训和教育增强方案。 职业发展是CEG的高度优先事项，将由经验丰富的CEG调查人员领导，并配备单独的 预算，但得到行政核心的支持。PPP发挥的关键作用是促进高 获得高额奖励项目并使奖励机制与CEG任务保持一致，有单独的预算和 领导监督，但也将得到行政核心的支持。

Introduction Section 6 describes in detail the tasks of the Administrative Core, the plan to carry out these tasks, and metrics used to evaluate the success of the implemented plans. Also described are membership requirements and procedures for the addition or removal of a member, changes in the structure of the CEG that have taken place, including changes in investigator membership, replacement of Research Cores with Focus Groups, and changes in Facilities Cores, which are more specifically detailed in Section 7 (page 667). Detailed implementation of the Career Development Program will be discussed in Section 4 (page 624). Report of the Pilot Projects Program and description of changes instituted in the program are detailed in Section 8, page 754. Discontinuation of the Outreach portion of the CEG is described below. The overarching objectives of the Center for Environmental Genetics are to improve human health through the integration of basic, genetic, clinical and epidemiological research into clinical practice and public health initiatives. Implementation of these objectives thus constitutes the primary objective of the Administrative Core, which will effectively manage the Center so that these goals can be achieved, creating a neighborhood of residents and facilities that will have an impact on Fig. 1 The Administrative Core will do this not only by overseeing the organizational, budgeting and reporting aspects of the grant, but also, and most importantly, by providing the leadership for the scientific and programmatic activities of the Center as a whole. The Director (Ho), Deputy Director (Puga) and Associate Directors (Lanphear and Nebert) have the responsibility for overall coordination and oversight of Center activities. They provide both scientific leadership and fiscal management for the Center. To carry out these responsibilities,they are assisted by the Internal Advisory Committee (IAC) composed of Focus Group Point Investigators (see Fig. 3 below), Facilities Cores Heads (Fig 1 with *), chosen CEG members, and other University faculty or staff who provide links with allied programs within the University. The Directors and chosen members of the IAC comprise a subcommittee which will be referred as the Executive Committee. It meets on a monthly basis and will assist the directors to oversee the day to day running of the CEG. The advise base is broaden by the inclusion of a Elite Council of UC/CCHMC Experts, comprised of a distinguished panel of UC/CCHMC research and administrative experts (Bishop, Broderick, Khurana-Hershey, and Stambrook), and an External Advisory Committee (EAC), made-up of a distinguished group of outstanding non-UC scientists who provide a strong advisory role focused on human genetics and environmental health as well as substantial experience in administration of large multidisciplinary programs. The Program Manager assists with the day-to-day management of the Center, fiscal monitoring, reporting, organization of group meetings, record keeping, and organization and planning Center activities, workshops and symposia. The Program Manager is assisted by a part-time (30% effort) Grant Administrator (also referred to as Financial Administrator) who oversees all grant related fiscal and compliance issues related to Center activities within and outside the University. The Program Manager is in charge of the semi-annual production of the CEG's Interface newsletter and the routine update of the CEG Website content, under the oversight of the Associate Director, Dr. Daniel Nebert. The Core provides administrative support for the Career Development Program (CDP) headed by Drs. Grace LeMasters and Daniel Woo (see Section 4, page 624) and the Pilot Project Program (PPP) coordinated by the Associate Director of the PPP, Dr. Daniel Nebert, and the Associate Director of Integrative Health, Dr. Bruce Lanphear. Three Facilities and Services (F&S) Cores have been proposed in this resubmission and they all report back to and will be evaluated on performance by the Administrative Core, with informal and formal input and advice from the Executive Committee, the Elite Council of the IAC and the EAC, which meet at different frequencies (detailed below) . The three F&S Cores are the Integrative Technologies Support Core (ITS, Section 7.1, page 667), the Integrative Health Services Core (Section 7.1, page 694) and the Bioinformatics Core (Section 7.3, page 721). Center research is supported by the F&A cores and the PPP awards, as well as training and educational enhancement programs organized by the Administrative Core. Career development, a high priority of the CEG, will be led by seasoned CEG investigators, with a separate budget but support from the Administrative Core. The key role played by the PPP, which is to promote high gain-high reward projects and align award mechanisms to CEG missions, has a separate budget and leadership oversight, but will also be supported by the Administrative Core.