Compact, Neon/Cryocooled NMR Magnets Assembled from Superconducting YBCO Annuli

由超导 YBCO 环形材料组装而成的紧凑型氖/低温冷却 NMR 磁体

• 批准号: 7860466
• 负责人: Yukikazu Iwasa
• 金额: $ 74.44万
• 依托单位: MASSACHUSETTS INSTITUTE OF TECHNOLOGY
• 依托单位国家: 美国
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-07-01 至 2013-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7860466
• 关键词: Caliber; Cell Nucleus; Charge; Clinical; Diagnostic tests; Dimensions; Engineering; Environment; Figs - dietary; Food; Food Industry; Frequencies; Goals; High temperature of physical object; Hour; Industry; Lead; Magnetism; Manufacturer Name; Measurement; Mechanics; Medical; NMR Spectroscopy; Neon; Patient Care; Pharmacologic Substance; Phase; Resolution; Shipping; Ships; Signal Transduction; Site; Solid; Steel; Surface; System; Techniques; Technology; Temperature; Thick; Time; barium copper yttrium oxide; base; cost; cryogenics; cryostat; density; design; drug development; innovation; magnetic field; new technology; operation; programs; prototype; response; tool; vibration

The specific aims of this Phase 1 of a 2-Phase program to design, manufacture, and operate a prototype 200MHz/38mm “bench-top” NMR “annulus" magnet (in Phase 2: 300MHz/43mm and 500MHz/43mm magnets) are four-fold: 1) Design, manufacture, and operation of a 200MHz/38mm bore prototype "NMR-class'' magnet based on an innovative design/operation concept that is particularly suited to a new type of persistent-mode NMR magnets for high-resolution "micro-NMR" spectroscopy; 2) Demonstrate, with the prototype, the unique feature of the annulus magnet that permits the magnet to be energized at one site (manufacturer) and transported to another site (user), while the magnet maintains its NMR-quality magnetic field; 3) Complete and demonstrate a "fieldtweaking'' technique that permits "micro-tuning" of the supercurrent distributions of annuli and hence the field homogeneity; and 4) Demonstrate the system's unique cryogenic system that: a) keeps a volume of solid neon and the annulus magnet at a nominal operating temperature of 15 K; b) enables the energized annulus magnet to maintain its persistent-mode field over the range 15-24K during a cryocooler-free "cooling-blank" period (~48 hours), when the energized magnet is shipped, or, if required, operated to provide a vibration-free environment for measurement. Our "high-field benchtop" annulus NMR magnet permits measurement with other nuclei, e.g., 23Na, 39K (rather than 1H), for which signal sensitivities are not sufficient with a "low-field bench-top" NMR magnet. The significance of this 2-phase program is that it would lead to a new type of persistent-mode, high-resolution “microcoil” NMR magnets, in which compactness, simple manufacturability, and ease of operation are the magnet's key features. The three features are vital for a widespread use in pharmaceutical and food industries for discovery and development of drugs and foods; even potentially, perhaps in ~15 years, by medical doctors as a new in-office tool for efficient medical care of patients. We expect the annulus magnet to be cost-effective, and combined with its compactness, it should become a new technology that the NMR magnet industry will in time unquestionably embrace: this, we believe, is the ultimate significance of this new annulus magnet technology. The proposed system has been described to the ultimate users, including those at Novartis and Pfizer; their responses have been highly positive.

设计、制造和操作200MHz/38mm“台式”核磁共振“环空”磁体原型（第二阶段：300MHz/43mm和500MHz/43mm磁体）的第一阶段的具体目标有四个方面：1)设计、制造和操作200MHz/38mm孔径原型“核磁共振级”磁体，基于创新的设计/操作概念，特别适合用于高分辨率“微核磁共振”光谱的新型持续模式核磁共振磁体；2)用原型演示环空磁铁的独特特性，该特性允许磁铁在一个地点（制造商）通电并运输到另一个地点（用户），同时磁铁保持其核磁共振质量的磁场；3)完成并演示一种“磁场调整”技术，该技术允许对环空的超电流分布进行“微调谐”，从而实现磁场的均匀性；4)演示该系统独特的低温系统：a)在15k的标称工作温度下保持固体氖气和环形磁铁的体积；b)使通电的环空磁体在无冷冻冷却器的“冷却空白”期间（~48小时）保持在15-24K范围内的持续模式磁场，当通电的磁体被运输时，或者，如果需要，操作以提供无振动的测量环境。我们的“高场台式”环空核磁共振磁体允许测量其他核，例如23Na， 39K（而不是1H），这些核的信号灵敏度不足以使用“低场台式”核磁共振磁体。这个两阶段计划的意义在于，它将导致一种新型的持久模式，高分辨率的“微线圈”核磁共振磁体，其中紧凑，易于制造和易于操作是磁体的关键特征。这三个特征对于在制药和食品工业中广泛使用药物和食品的发现和开发至关重要；甚至可能在大约15年内，被医生作为一种新的办公工具，为病人提供有效的医疗护理。我们期望环空磁体具有成本效益，并且结合其紧凑性，它应该成为核磁共振磁体行业将毫无疑问地接受的新技术：我们相信，这是这种新型环空磁体技术的最终意义。提议的系统已被描述给最终用户，包括诺华和辉瑞的用户；他们的反应非常积极。

项目成果

Trapped Field Characteristics of Stacked YBCO Thin Plates for Compact NMR Magnets: Spatial Field Distribution and Temporal Stability.

• DOI: 10.1109/tasc.2010.2043832
• 发表时间: 2010-06-01
• 期刊: IEEE transactions on applied superconductivity : a publication of the IEEE Superconductivity Committee
• 作者: Hahn S;Kim SB;Ahn MC;Voccio J;Bascuñán J;Iwasa Y
• 通讯作者: Iwasa Y

Field Performance of an Optimized Stack of YBCO Square "Annuli" for a Compact NMR Magnet.

• DOI: 10.1109/tasc.2010.2103920
• 发表时间: 2011-06
• 期刊: IEEE transactions on applied superconductivity : a publication of the IEEE Superconductivity Committee
• 作者: Hahn S;Voccio J;Bermond S;Park DK;Bascuñán J;Kim SB;Masaru T;Iwasa Y
• 通讯作者: Iwasa Y

Numerical and Experimental Study to Fabricate the New Type Compact NMR Device Using Stacked HTS Bulks.

使用堆叠高温超导块体制造新型紧凑型核磁共振装置的数值和实验研究。

• DOI: 10.1109/tasc.2011.2182170
• 发表时间: 2012
• 期刊: IEEE transactions on applied superconductivity : a publication of the IEEE Superconductivity Committee
• 作者: Kim,SB;Kimoto,T;Yano,Y;Hahn,S;Iwasa,Y
• 通讯作者: Iwasa,Y

Operation of a 130-MHz/9-mm Compact HTS Annulus Magnet With a Micro-NMR Probe.

使用微型 NMR 探头操作 130 MHz/9 mm 紧凑型 HTS 环形磁铁。

• DOI: 10.1109/tasc.2014.2367658
• 发表时间: 2015
• 期刊: IEEE transactions on applied superconductivity : a publication of the IEEE Superconductivity Committee
• 作者: Hahn,Seungyong;Kim,Youngjae;Song,Jungbin;Voccio,JohnP;Chu,Yong;Bascuñán,Juan;Tomita,Masaru;Iwasa,Yukikazu
• 通讯作者: Iwasa,Yukikazu

Field performance of a prototype compact YBCO "annulus" magnet for micro-NMR spectroscopy.

• DOI: 10.1016/j.physc.2012.12.013
• 发表时间: 2013-03
• 期刊: Physica. C, Superconductivity
• 作者: Blair Gagnon;S. Hahn;D. Park;J. Voccio;Kwangmin Kim;J. Bascuñân;Y. Iwasa