Compact, Neon/Cryocooled NMR Magnets Assembled from Superconducting YBCO Annuli

由超导 YBCO 环形材料组装而成的紧凑型氖/低温冷却 NMR 磁体

• 批准号: 7860466
• 负责人: Yukikazu Iwasa
• 金额: $ 74.44万
• 依托单位: MASSACHUSETTS INSTITUTE OF TECHNOLOGY
• 依托单位国家: 美国
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-07-01 至 2013-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7860466
• 关键词: Caliber; Cell Nucleus; Charge; Clinical; Diagnostic tests; Dimensions; Engineering; Environment; Figs - dietary; Food; Food Industry; Frequencies; Goals; High temperature of physical object; Hour; Industry; Lead; Magnetism; Manufacturer Name; Measurement; Mechanics; Medical; NMR Spectroscopy; Neon; Patient Care; Pharmacologic Substance; Phase; Resolution; Shipping; Ships; Signal Transduction; Site; Solid; Steel; Surface; System; Techniques; Technology; Temperature; Thick; Time; barium copper yttrium oxide; base; cost; cryogenics; cryostat; density; design; drug development; innovation; magnetic field; new technology; operation; programs; prototype; response; tool; vibration

The specific aims of this Phase 1 of a 2-Phase program to design, manufacture, and operate a prototype 200MHz/38mm “bench-top” NMR “annulus" magnet (in Phase 2: 300MHz/43mm and 500MHz/43mm magnets) are four-fold: 1) Design, manufacture, and operation of a 200MHz/38mm bore prototype "NMR-class'' magnet based on an innovative design/operation concept that is particularly suited to a new type of persistent-mode NMR magnets for high-resolution "micro-NMR" spectroscopy; 2) Demonstrate, with the prototype, the unique feature of the annulus magnet that permits the magnet to be energized at one site (manufacturer) and transported to another site (user), while the magnet maintains its NMR-quality magnetic field; 3) Complete and demonstrate a "fieldtweaking'' technique that permits "micro-tuning" of the supercurrent distributions of annuli and hence the field homogeneity; and 4) Demonstrate the system's unique cryogenic system that: a) keeps a volume of solid neon and the annulus magnet at a nominal operating temperature of 15 K; b) enables the energized annulus magnet to maintain its persistent-mode field over the range 15-24K during a cryocooler-free "cooling-blank" period (~48 hours), when the energized magnet is shipped, or, if required, operated to provide a vibration-free environment for measurement. Our "high-field benchtop" annulus NMR magnet permits measurement with other nuclei, e.g., 23Na, 39K (rather than 1H), for which signal sensitivities are not sufficient with a "low-field bench-top" NMR magnet. The significance of this 2-phase program is that it would lead to a new type of persistent-mode, high-resolution “microcoil” NMR magnets, in which compactness, simple manufacturability, and ease of operation are the magnet's key features. The three features are vital for a widespread use in pharmaceutical and food industries for discovery and development of drugs and foods; even potentially, perhaps in ~15 years, by medical doctors as a new in-office tool for efficient medical care of patients. We expect the annulus magnet to be cost-effective, and combined with its compactness, it should become a new technology that the NMR magnet industry will in time unquestionably embrace: this, we believe, is the ultimate significance of this new annulus magnet technology. The proposed system has been described to the ultimate users, including those at Novartis and Pfizer; their responses have been highly positive.

该2阶段计划的第1阶段的具体目标是设计、制造和操作原型200 MHz/38 mm“台式”NMR“环形”磁体。（在第2阶段：300 MHz/43 mm和500 MHz/43 mm磁体）是四重的：1）设计、制造、基于创新设计的200 MHz/38 mm孔径原型“NMR级”磁体的运行/操作概念，特别适合于一种新型的持久模式核磁共振磁铁的高分辨率“微核磁共振”光谱;（2）通过原型演示，环形磁体的独特特征允许磁体在一个位置被激励3）完成并演示“场调整”技术，该技术允许对环的超电流分布进行“微调”，从而实现场均匀性;以及4）展示该系统的独特的低温系统，该低温系统：a）将一定体积的固体氖和环形磁体保持在15 K的标称操作温度; B）使通电的环形磁体能够在无低温冷却器的“冷却空白”期间在15- 24 K的范围内维持其持续模式场（约48小时），当通电磁铁装运时，或者，如果需要，操作以提供无振动的测量环境。我们的“高场台式”环形NMR磁体允许测量其他核，例如，23 Na，39 K（而不是1H），对于这些信号灵敏度，“低场台式”NMR磁体是不够的。这两个阶段的计划的意义在于，它将导致一种新型的持续模式，高分辨率的“微线圈”核磁共振磁体，其中紧凑，简单的可制造性和易于操作是磁体的关键特征。这三个特征对于在制药和食品工业中广泛使用以发现和开发药物和食品至关重要;甚至可能，也许在约15年内，由医生作为有效医疗护理患者的新的办公室工具。我们期望环形磁体具有成本效益，并且结合其紧凑性，它应该成为NMR磁体行业将及时毫无疑问地接受的新技术：我们相信，这是这种新的环形磁体技术的最终意义。已向包括诺华和辉瑞在内的最终用户介绍了拟议的系统;他们的反应非常积极。

项目成果

Trapped Field Characteristics of Stacked YBCO Thin Plates for Compact NMR Magnets: Spatial Field Distribution and Temporal Stability.

• DOI: 10.1109/tasc.2010.2043832
• 发表时间: 2010-06-01
• 期刊: IEEE transactions on applied superconductivity : a publication of the IEEE Superconductivity Committee
• 作者: Hahn S;Kim SB;Ahn MC;Voccio J;Bascuñán J;Iwasa Y
• 通讯作者: Iwasa Y

Field Performance of an Optimized Stack of YBCO Square "Annuli" for a Compact NMR Magnet.

• DOI: 10.1109/tasc.2010.2103920
• 发表时间: 2011-06
• 期刊: IEEE transactions on applied superconductivity : a publication of the IEEE Superconductivity Committee
• 作者: Hahn S;Voccio J;Bermond S;Park DK;Bascuñán J;Kim SB;Masaru T;Iwasa Y
• 通讯作者: Iwasa Y

Numerical and Experimental Study to Fabricate the New Type Compact NMR Device Using Stacked HTS Bulks.

使用堆叠高温超导块体制造新型紧凑型核磁共振装置的数值和实验研究。

• DOI: 10.1109/tasc.2011.2182170
• 发表时间: 2012
• 期刊: IEEE transactions on applied superconductivity : a publication of the IEEE Superconductivity Committee
• 作者: Kim,SB;Kimoto,T;Yano,Y;Hahn,S;Iwasa,Y
• 通讯作者: Iwasa,Y

Field performance of a prototype compact YBCO "annulus" magnet for micro-NMR spectroscopy.

• DOI: 10.1016/j.physc.2012.12.013
• 发表时间: 2013-03
• 期刊: Physica. C, Superconductivity
• 作者: Blair Gagnon;S. Hahn;D. Park;J. Voccio;Kwangmin Kim;J. Bascuñân;Y. Iwasa

Operation of a 130-MHz/9-mm Compact HTS Annulus Magnet With a Micro-NMR Probe.

使用微型 NMR 探头操作 130 MHz/9 mm 紧凑型 HTS 环形磁铁。

• DOI: 10.1109/tasc.2014.2367658
• 发表时间: 2015
• 期刊: IEEE transactions on applied superconductivity : a publication of the IEEE Superconductivity Committee
• 作者: Hahn,Seungyong;Kim,Youngjae;Song,Jungbin;Voccio,JohnP;Chu,Yong;Bascuñán,Juan;Tomita,Masaru;Iwasa,Yukikazu
• 通讯作者: Iwasa,Yukikazu