DEVELOPMENT OF A MICRORT SYSTEM

MICRORT系统的开发

• 批准号: 7826778
• 负责人: Buck E. Rogers
• 金额: $ 35.67万
• 依托单位: WASHINGTON UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-05-01 至 2011-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7826778
• 关键词: Address; Animal Experiments; Animals; Area; Arts; Biomedical Engineering; Boxing; Brachytherapy; Characteristics; Clinical; Collection; Collimator; Computer software; Computers; Conformal Radiotherapy; Data; Detection; Development; Development Plans; Devices; Diagnosis; Dose; Dose-Rate; Electron Transport; Electrons; Energy-Generating Resources; Evaluation; Extravasation; Fostering; Functional Imaging; Funding Mechanisms; Genetic Markers; Goals; Grant; Heterogeneity; Human; Image; Imaging Device; Immobilization; In Situ; Institution; Investigation; Knowledge; Lasers; Learning; Malignant Neoplasms; Measures; Mechanics; Missouri; Modeling; Molecular; Molecular Conformation; Mus; NIH Program Announcements; Noise; Organ; Penetration; Pharmaceutical Preparations; Positioning Attribute; Process; Protocols documentation; Radiation; Radiation therapy; Radiation-Sensitizing Agents; Radioactive; Radiobiology; Rattus; Reporter; Research; Resolution; Resources; Robotics; Security; Shapes; Silicon; Source; Staging; Support System; System; Techniques; Technology; Testing; Therapeutic; Translating; Tube; Universities; Weight; Work; absorption; anticancer research; base; bone; cancer therapy; chemotherapy; cone-beam computed tomography; design; dosimetry; experience; improved; in vivo; instrument; instrumentation; interstitial; irradiation; meetings; molecular imaging; molecular marker; novel; pre-clinical; pre-clinical research; prototype; quality assurance; research study; response; simulation; skills; tool; treatment planning; tumor; voltage

The overall aim of this project is to develop novel conformal small-animal irradiator, suitable for studying genetic markers of radiation response and radiobiological models at therapeutic dose levels. There has been a revolution in functional imaging that has coincided with the development of small animal imaging devices, including microCT, microMRI, and microSPECT. Many of the institutions that have acquired these devices use them to study the efficacy of molecular markers for the diagnosis, detection, and characterization of cancer. An important component of these studies is the evaluation of response to therapeutic doses of radiation; however, the technology of animal irradiation is crude, making reproducible irradiation of in situ tumors and normal organs difficult. We have designed an image-guided small animal irradiator (microRT) that will deliver customized, conformal dose distributions to rats and mice that are highly efficient, accurately localized, with accurate dosimetry, and conformal therapy treatment planning, to support quantitative molecular imaging studies and radiobiological experiments. The system is based on a commercially available high spatial resolution orthovoltage x-ray irradiator and the radiation beam delivery will be computer controlled and automated. On-board cone-beam CT imaging will be used to aid the treatment planner in optimizing the radiation beam treatment plan. One of the sub-goals is to design the microRT unit to be highly efficient to improve throughput, so the treatment planning and delivery process will be interleaved with concurrent imaging, treatment planning, and dose delivery. Our first aim (SA1) is to build the irradiator using the existing design. The second aim (SA2) is to validate that the unit built in SA1 meets the existing specifications. The successful completion of these specific aims will open a new field of preclinical micro imagingguided radiobiology investigations on small animals.

该项目的总体目标是开发新型适形小动物辐照器， 适合研究辐射反应的遗传标记和放射生物学模型 治疗剂量水平。功能成像领域发生了一场革命 恰逢小动物成像设备的发展，包括 microCT、 显微 MRI 和显微 SPECT。许多已购买这些设备的机构 使用它们来研究分子标记在诊断、检测和治疗中的功效 癌症的特征。这些研究的一个重要组成部分是评估 对治疗剂量的辐射的反应；然而，动物辐照技术 是粗糙的，使得原位肿瘤和正常器官的可重复照射变得困难。我们 设计了一种图像引导的小动物辐照器（microRT），可以提供 为大鼠和小鼠定制、保形的高效剂量分布， 精确定位、精确剂量测定和适形治疗治疗计划， 支持定量分子成像研究和放射生物学实验。这 系统基于商用高空间分辨率正电压 X 射线 辐照器和辐射束传输将由计算机控制和自动化。 机载锥束 CT 成像将用于帮助治疗计划者优化 放射束治疗计划。子目标之一是设计 microRT 单元 高效地提高吞吐量，因此治疗计划和交付过程 将与并发成像、治疗计划和剂量输送交织在一起。我们的 第一个目标（SA1）是使用现有设计建造辐照器。第二个目标（SA2） 是为了验证 SA1 中构建的单元是否满足现有规范。成功者 这些具体目标的完成将开辟临床前显微成像引导的新领域 小动物的放射生物学研究。

项目成果

Characterization of speckle in lung images acquired with a benchtop in-line x-ray phase-contrast system.

• DOI: 10.1088/0031-9155/58/12/4237
• 发表时间: 2013-06-21
• 期刊: Physics in medicine and biology
• 影响因子: 3.5
• 作者: Garson AB 3rd;Izaguirre EW;Price SG;Anastasio MA
• 通讯作者: Anastasio MA