DEVELOPMENT OF A MICRORT SYSTEM
MICRORT系统的开发
基本信息
- 批准号:7826778
- 负责人:
- 金额:$ 35.67万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2009
- 资助国家:美国
- 起止时间:2009-05-01 至 2011-04-30
- 项目状态:已结题
- 来源:
- 关键词:AddressAnimal ExperimentsAnimalsAreaArtsBiomedical EngineeringBoxingBrachytherapyCharacteristicsClinicalCollectionCollimatorComputer softwareComputersConformal RadiotherapyDataDetectionDevelopmentDevelopment PlansDevicesDiagnosisDoseDose-RateElectron TransportElectronsEnergy-Generating ResourcesEvaluationExtravasationFosteringFunctional ImagingFunding MechanismsGenetic MarkersGoalsGrantHeterogeneityHumanImageImaging DeviceImmobilizationIn SituInstitutionInvestigationKnowledgeLasersLearningMalignant NeoplasmsMeasuresMechanicsMissouriModelingMolecularMolecular ConformationMusNIH Program AnnouncementsNoiseOrganPenetrationPharmaceutical PreparationsPositioning AttributeProcessProtocols documentationRadiationRadiation therapyRadiation-Sensitizing AgentsRadioactiveRadiobiologyRattusReporterResearchResolutionResourcesRoboticsSecurityShapesSiliconSourceStagingSupport SystemSystemTechniquesTechnologyTestingTherapeuticTranslatingTubeUniversitiesWeightWorkabsorptionanticancer researchbasebonecancer therapychemotherapycone-beam computed tomographydesigndosimetryexperienceimprovedin vivoinstrumentinstrumentationinterstitialirradiationmeetingsmolecular imagingmolecular markernovelpre-clinicalpre-clinical researchprototypequality assuranceresearch studyresponsesimulationskillstooltreatment planningtumorvoltage
项目摘要
The overall aim of this project is to develop novel conformal small-animal irradiator,
suitable for studying genetic markers of radiation response and radiobiological models at
therapeutic dose levels. There has been a revolution in functional imaging that has
coincided with the development of small animal imaging devices, including microCT,
microMRI, and microSPECT. Many of the institutions that have acquired these devices
use them to study the efficacy of molecular markers for the diagnosis, detection, and
characterization of cancer. An important component of these studies is the evaluation of
response to therapeutic doses of radiation; however, the technology of animal irradiation
is crude, making reproducible irradiation of in situ tumors and normal organs difficult. We
have designed an image-guided small animal irradiator (microRT) that will deliver
customized, conformal dose distributions to rats and mice that are highly efficient,
accurately localized, with accurate dosimetry, and conformal therapy treatment planning,
to support quantitative molecular imaging studies and radiobiological experiments. The
system is based on a commercially available high spatial resolution orthovoltage x-ray
irradiator and the radiation beam delivery will be computer controlled and automated.
On-board cone-beam CT imaging will be used to aid the treatment planner in optimizing
the radiation beam treatment plan. One of the sub-goals is to design the microRT unit to
be highly efficient to improve throughput, so the treatment planning and delivery process
will be interleaved with concurrent imaging, treatment planning, and dose delivery. Our
first aim (SA1) is to build the irradiator using the existing design. The second aim (SA2)
is to validate that the unit built in SA1 meets the existing specifications. The successful
completion of these specific aims will open a new field of preclinical micro imagingguided
radiobiology investigations on small animals.
本项目的总体目标是开发新型的小动物适形辐照器,
适用于研究辐射反应的遗传标记和放射生物学模型,
治疗剂量水平。在功能成像方面发生了一场革命,
与小动物成像设备的发展相吻合,包括microCT,
microMRI和microSPECT。许多获得这些设备的机构
使用它们来研究分子标记物用于诊断、检测和
癌症的特征。这些研究的一个重要组成部分是评估
对治疗剂量的辐射的反应;然而,动物辐射技术
是粗糙的,使得原位肿瘤和正常器官的可重复照射变得困难。我们
设计了一种图像引导的小动物辐照器(microRT),
定制的,适形的剂量分布到大鼠和小鼠,是非常有效的,
精确定位,精确的剂量测定,和适形治疗计划,
以支持定量分子成像研究和放射生物学实验。的
该系统基于商业上可获得的高空间分辨率正电压X射线
辐照器和辐射束输送将由计算机控制和自动化。
机载锥形束CT成像将用于帮助治疗计划者优化
放射线治疗计划其中一个子目标是设计microRT单元,
能够高效地提高吞吐量,因此治疗计划和输送过程
将与同步成像、治疗计划和剂量输送交错。我们
第一个目标(SA 1)是使用现有设计构建辐照器。第二个目标(SA 2)
是为了验证SA 1中构建的单元是否符合现有规范。成功
这些特定目标的完成将开辟临床前显微成像引导的新领域,
小动物的放射生物学研究。
项目成果
期刊论文数量(1)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
Characterization of speckle in lung images acquired with a benchtop in-line x-ray phase-contrast system.
- DOI:10.1088/0031-9155/58/12/4237
- 发表时间:2013-06-21
- 期刊:
- 影响因子:3.5
- 作者:Garson AB 3rd;Izaguirre EW;Price SG;Anastasio MA
- 通讯作者:Anastasio MA
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Buck E. Rogers其他文献
789: Integrin antagonism to mitigate radiation-induced pulmonary fibrosis: iDISCO-based 3-D SHG imaging
789:整联蛋白拮抗以减轻辐射诱导的肺纤维化:基于IDISCO的3-D SHG成像
- DOI:
10.1016/s0167-8140(24)01324-0 - 发表时间:
2024-05-01 - 期刊:
- 影响因子:5.300
- 作者:
William C Y Lo;Peter G. Ruminiski;Amanda Klaas;Felicia Grogan;Lori Strong;Julie K. Schwarz;Clifford G. Robinison;Buck E. Rogers;Carmen Bergom - 通讯作者:
Carmen Bergom
#27. First-in-human evaluation of safety and dosimetry of <sup>64</sup>Cu-LLP2A for PET imaging
- DOI:
10.1016/j.jbo.2024.100565 - 发表时间:
2024-04-01 - 期刊:
- 影响因子:
- 作者:
Richard Laforest;Anchal Ghai;Tyler J. Fraum;Reiko Oyama;Jennifer Frye;Helen Kaemmerer;Greg Gaehle;Tom Voller;Cedric Mpoy;Buck E. Rogers;Mark Fiala;Kooresh I. Shoghi;Samuel Achilefu;Michael Rettig;Ravi Vij;John F. DiPersio;Sally Schwarz;Monica Shokeen;Farrokh Dehdashti - 通讯作者:
Farrokh Dehdashti
Using Integrin αsubv/subβsub6/sub-Targeted Positron Emission Tomography Imaging to Longitudinally Monitor Radiation-Induced Pulmonary Fibrosis In Vivo
利用整合素αvβ6靶向正电子发射断层成像术在体内纵向监测放射性肺纤维化
- DOI:
10.1016/j.ijrobp.2024.08.034 - 发表时间:
2025-02-01 - 期刊:
- 影响因子:6.500
- 作者:
William C.Y. Lo;Cristian W. Villas Boas;Truc T. Huynh;Amanda Klaas;Felicia Grogan;Lori Strong;Pamela Samson;Clifford G. Robinson;Buck E. Rogers;Carmen Bergom - 通讯作者:
Carmen Bergom
Buck E. Rogers的其他文献
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{{ truncateString('Buck E. Rogers', 18)}}的其他基金
Small Molecule GPCR Ligands for Oncologic Imaging
用于肿瘤成像的小分子 GPCR 配体
- 批准号:
9977505 - 财政年份:2020
- 资助金额:
$ 35.67万 - 项目类别:
The PET Radiotracer Translation and Resource Center (PET-RTRC) Training & Dissemination
PET 放射性示踪剂翻译和资源中心 (PET-RTRC) 培训
- 批准号:
10715917 - 财政年份:2018
- 资助金额:
$ 35.67万 - 项目类别:
SYNTHESIS OF CATIONIC STEROID COMPOUNDS FOR DETECTION OF BACTERIAL INFECTIONS
用于检测细菌感染的阳离子类固醇化合物的合成
- 批准号:
9090097 - 财政年份:2015
- 资助金额:
$ 35.67万 - 项目类别:
DEVELOPMENT OF PET RADIOPHARMACEUTICALS TARGETING GRPR
针对 GRPR 的 PET 放射性药物的开发
- 批准号:
7731138 - 财政年份:2009
- 资助金额:
$ 35.67万 - 项目类别:
DEVELOPMENT OF PET RADIOPHARMACEUTICALS TARGETING GRPR
针对 GRPR 的 PET 放射性药物的开发
- 批准号:
8077958 - 财政年份:2009
- 资助金额:
$ 35.67万 - 项目类别:
DEVELOPMENT OF PET RADIOPHARMACEUTICALS TARGETING GRPR
针对 GRPR 的 PET 放射性药物的开发
- 批准号:
8266454 - 财政年份:2009
- 资助金额:
$ 35.67万 - 项目类别:
Somatostatin Receptor Based PET Imaging of Gene Transfer
基于生长抑素受体的基因转移 PET 成像
- 批准号:
7015559 - 财政年份:2005
- 资助金额:
$ 35.67万 - 项目类别:
Somatostatin Receptor Based PET Imaging of Gene Transfer
基于生长抑素受体的基因转移 PET 成像
- 批准号:
6856960 - 财政年份:2005
- 资助金额:
$ 35.67万 - 项目类别:
Somatostatin Receptor Based PET Imaging of Gene Transfer
基于生长抑素受体的基因转移 PET 成像
- 批准号:
7227724 - 财政年份:2005
- 资助金额:
$ 35.67万 - 项目类别:
Somatostatin Receptor Based PET Imaging of Gene Transfer
基于生长抑素受体的基因转移 PET 成像
- 批准号:
7433269 - 财政年份:2005
- 资助金额:
$ 35.67万 - 项目类别:
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