Immune dysfunction associated with early life heavy metal exposure
与生命早期重金属暴露相关的免疫功能障碍
基本信息
- 批准号:8092111
- 负责人:
- 金额:$ 13.39万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2011
- 资助国家:美国
- 起止时间:2011-06-01 至 2016-02-29
- 项目状态:已结题
- 来源:
- 关键词:AccountingActive LearningAddressAdolescenceAgeAllergicAllergic DiseaseAntibodiesAntinuclear AntibodiesAreaAutoantibodiesAutoimmune DiseasesAutoimmune ProcessAutoimmunityB-LymphocytesBiological MarkersBirthBreast FeedingCause of DeathCell Differentiation processChildChildhoodChronicChronic DiseaseCohort StudiesCytokine GeneDNA MethylationData SetDescriptive EpidemiologyDevelopmentDevelopment PlansDiseaseDoctor of MedicineDoctor of PhilosophyEnvironmental EpidemiologyEnvironmental HealthEpidemiologistEpigenetic ProcessEquilibriumEtiologyExposure toFetal DevelopmentFrequenciesGenesGenetic VariationGoalsGrowthHealthHealth PolicyHeavy MetalsHumanImmuneImmune System DiseasesImmune responseImmune systemImmunologicsImmunologistImmunologyImmunotoxicologyKnowledgeLaboratory ResearchLeadLearningLifeLinkLocus Control RegionLongevityLupusMeasurementMeasuresMediatingMentorshipMercuryMetal exposureMethodsMethylationMexicoModelingMolecular EpidemiologyPharmacoepidemiologyPhenotypePopulationPopulation StudyPopulation SurveillancePredispositionPrincipal InvestigatorPublic HealthQualifyingQuality of lifeRegistriesRegulatory T-LymphocyteResearchResearch PersonnelResearch TrainingRiskRisk FactorsRoleStagingStimulusStructureT-LymphocyteTimeToxic Environmental SubstancesTrainingWomancareercareer developmentclinical epidemiologycohortcytokinedemethylationdesignearly childhoodearly life exposureepidemiology studyexperiencefetalgene environment interactionhuman diseasein uteromicrobialmiddle agepopulation basedprenatalprogramsrheumatologistsex
项目摘要
DESCRIPTION (provided by applicant)
The overarching goal of this K01 proposal is for the candidate to acquire the expertise necessary to lead a research program in environmental epidemiology applied to immune-mediated disorders. Dr. Somers is trained as an epidemiologist, with significant expertise in the clinical epidemiology of lupus, public health surveillance of chronic disease, and descriptive epidemiology of autoimmune diseases. Immediate career goals are to expand on this background by acquiring comprehensive training in relevant areas in environmental health sciences, including molecular epidemiology, immunotoxicology, and epigenetics. Long-term career goals are to unravel the etiologies of autoimmune and other immune-mediated disorders, an in particular, to identify the role of potentially modifiable early life exposures.
The proposed training and research will be conducted under the mentorship of Howard Hu, M.D. MPH Sc.D. and Bruce Richardson, M.D. Ph.D. Dr. Hu is a recognized leader in environmental epidemiology and health effects of heavy metals. Dr. Richardson is a rheumatologist and immunologist, and has performed groundbreaking laboratory research related to epigenetics and lupus. The Career Development Plan will include both structured and informal learning activities that together will provide in depth training in the following growth areas for the candidate: (a) Environmental health science and molecular epidemiology, including exposure assessment, gene-environment interactions, and immunotoxicology; (b) developmental and maternal-fetal immunology; (c) assessment and interpretation of biomarkers of immune phenotype and function; (d) epigenetics methods, including DNA methylation, related to health and human disease.
The proposed research will be a birth cohort study investigating the association between early life heavy metal exposure and immune dysregulation. The study population will be the Early Life Exposures in Mexico to Environmental Toxicants (ELEMENT) birth cohort (PI: Dr. Hu), which has been extensively characterized in terms of heavy metal exposures, including mercury (prenatal and childhood measurement). This proposal will be the first to investigate immunologic endpoints in this birth cohort. Emphasis will be exploration of the association between in utero and early childhood exposure to mercury and immune perturbations, which may be relevant in terms of autoimmune and allergic disease. Immune parameters will include auto-antibodies, cytokines, and gene-specific methylation levels relevant to T helper cell differentiation. Balance of Th subsets is important in directing host immune responses, and clearly influenced by microbial stimuli. This project addresses a critical gap in knowledge in the role of non-microbial exposures in immune modeling, and will represent a significant career enhancement opportunity for the candidate.
描述(由申请人提供)
该K 01提案的总体目标是候选人获得必要的专业知识,以领导应用于免疫介导疾病的环境流行病学研究计划。 索默斯博士是一名流行病学家,在狼疮的临床流行病学、慢性病的公共卫生监测和自身免疫性疾病的描述性流行病学方面具有重要的专业知识。 近期的职业目标是通过获得环境健康科学相关领域的全面培训来扩大这一背景,包括分子流行病学,免疫毒理学和表观遗传学。 长期的职业目标是解开自身免疫和其他免疫介导的疾病的病因,特别是,以确定潜在的可改变的早期生活暴露的作用。
拟议的培训和研究将在霍华德胡医学博士的指导下进行。公共卫生硕士和医学博士布鲁斯理查森。博士 胡博士是环境流行病学和重金属对健康影响方面公认的领导者。Richardson博士是一位风湿病学家和免疫学家,并进行了与表观遗传学和狼疮相关的开创性实验室研究。职业发展计划将包括结构化和非正式的学习活动,共同为候选人提供以下成长领域的深入培训:(a)环境健康科学和分子流行病学,包括暴露评估、基因-环境相互作用和免疫毒理学;(B)发育和母胎免疫学;(c)评估和解释免疫表型和功能的生物标志物;(d)与健康和人类疾病有关的表观遗传学方法,包括DNA甲基化。
拟议的研究将是一项出生队列研究,调查早期重金属暴露与免疫失调之间的关系。研究人群将是墨西哥早期环境毒物暴露(ELEMENT)出生队列(PI:Dr. Hu),该队列已在重金属暴露方面进行了广泛表征,包括汞(产前和儿童测量)。该提案将是第一个研究该出生队列中免疫学终点的提案。 重点将是探索子宫内和儿童早期接触汞和免疫紊乱之间的关联,这可能与自身免疫性和过敏性疾病有关。 免疫参数将包括自身抗体、细胞因子和与T辅助细胞分化相关的基因特异性甲基化水平。Th亚群的平衡在指导宿主免疫应答中是重要的,并且明显受微生物刺激的影响。该项目解决了非微生物暴露在免疫建模中的作用方面的关键知识差距,并将为候选人提供重要的职业发展机会。
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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Emily Catherine Somers其他文献
Emily Catherine Somers的其他文献
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{{ truncateString('Emily Catherine Somers', 18)}}的其他基金
Michigan Lupus Epidemiology and Surveillance (MILES) Program Longitudinal Cohort & Biobank
密歇根狼疮流行病学和监测 (MILES) 计划纵向队列
- 批准号:
10201405 - 财政年份:2019
- 资助金额:
$ 13.39万 - 项目类别:
Michigan Lupus Epidemiology & Surveillance (MILES) Program Longitudinal Cohort & Biobank
密歇根狼疮流行病学
- 批准号:
9313640 - 财政年份:2016
- 资助金额:
$ 13.39万 - 项目类别:
Michigan Lupus Epidemiology & Surveillance (MILES) Program Longitudinal Cohort & Biobank
密歇根狼疮流行病学
- 批准号:
9220973 - 财政年份:2016
- 资助金额:
$ 13.39万 - 项目类别:
Michigan Lupus Epidemiology & Surveillance (MILES) Program Longitudinal Cohort
密歇根狼疮流行病学
- 批准号:
8718778 - 财政年份:2012
- 资助金额:
$ 13.39万 - 项目类别:
Michigan Lupus Epidemiology & Surveillance (MILES) Program Longitudinal Cohort
密歇根狼疮流行病学
- 批准号:
8534940 - 财政年份:2012
- 资助金额:
$ 13.39万 - 项目类别:
Michigan Lupus Epidemiology & Surveillance (MILES) Program Longitudinal Cohort
密歇根狼疮流行病学
- 批准号:
8236581 - 财政年份:2012
- 资助金额:
$ 13.39万 - 项目类别:
Immune dysfunction associated with early life heavy metal exposure
与生命早期重金属暴露相关的免疫功能障碍
- 批准号:
8274882 - 财政年份:2011
- 资助金额:
$ 13.39万 - 项目类别:
Immune dysfunction associated with early life heavy metal exposure
与生命早期重金属暴露相关的免疫功能障碍
- 批准号:
8627605 - 财政年份:2011
- 资助金额:
$ 13.39万 - 项目类别:
Immune dysfunction associated with early life heavy metal exposure
与生命早期重金属暴露相关的免疫功能障碍
- 批准号:
8435492 - 财政年份:2011
- 资助金额:
$ 13.39万 - 项目类别:
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