Biology and Pathobiology of Kr??ppel-Like Factors (KLFs)

Kr??ppel 样因子 (KLF) 的生物学和病理学

• 批准号: 8004659
• 负责人: Vincent W Yang
• 金额: $ 0.35万
• 依托单位: FEDERATION OF AMER SOC FOR EXPER BIOLOGY
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-08-01 至 2011-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8004659
• 关键词: Address; Award; Basic Science; Bioinformatics; Biology; Biophysics; Cardiology; Cardiovascular system; Cellular biology; Clinical Sciences; Collaborations; Development; Developmental Biology; Diabetes Mellitus; Differentiation and Growth; Digestive System Disorders; Discipline; Disease; Endocrinology; Erythroid; Family; Family member; Fostering; Functional disorder; Funding; Gastroenterology; Genetic; Goals; Hematology; Hepatology; Immune system; Inflammatory; International; Lead; Malignant Neoplasms; Molecular Biology; Obesity; Oral; Organ; Participant; Physiological; Physiological Processes; Physiology; Pluripotent Stem Cells; Process; Request for Applications; Research; Research Personnel; Role; Schedule; Signal Transduction; Somatic Cell; System; Therapeutic; Time; Travel; Zinc Fingers; abstracting; base; body system; design; embryonic stem cell; erythroid Kruppel-like factor; human disease; innovation; interest; meetings; member; oncology; planetary Atmosphere; pluripotency; posters; programs; public health relevance; respiratory; stem cell biology; symposium; therapeutic development; transcription factor

DESCRIPTION (provided by applicant): This application requests funding in partial support of a FASEB Summer Research Conference (SRC) entitled Biology and Pathobiology of Kruppel-Like Factors (KLFs). The 5-day conference is the first international meeting on this topic that will be held in the U. S. Kruppel-like factors are a family of zinc finger-containing transcription factors that represents a rapidly advancing field. Since the identification of the first member of this family, Erythroid Kr|ppel-Like Factor (EKLF or KLF1), some 16 years ago, an additional 21 members have been identified. Studies have indicated that KLFs exert important functions in diverse physiological processes involving the cardiovascular, digestive, respiratory, hematological and immune systems and in pathological states such as cancer, obesity, diabetes, and inflammatory conditions, among others. Recent studies have also implicated KLFs in the reprogramming of somatic cells to inducible pluripotent stem (iPS) cells and in maintaining the pluripotency of embryonic stem cells. The proposed symposium is designed to bring together a group of international leaders in the field of KLF research with the goal of stimulating discussion and fostering collaboration. The potential for therapeutic development in cardiovascular, cancer, diabetes, and inflammatory diseases based on KLF biology is a distinct possibility that may result from the meeting. The SPECIFIC OBJECTIVES of the meeting are: a. To provide a scientific program at the forefront of KLF research that is organized around the themes of physiological functions and organ-based pathophysiology of diseases. b. To provide a venue for meaningful interchanges among investigators in the KLF field with which to foster interactions and potential collaborations in both basic and clinical sciences. c. To provide a scientific platform with which to encourage active participation of young investigators and trainees. d. To provide an educational forum to participants. At the end of conference, we will generate a summary of the conference talks and envision that the conference will stimulate robust discussion and exciting new ideas with which to advance the field. We also anticipate to continue the conference platform and establish a biannual conference schedule on similar topics.

描述（由申请人提供）：本申请要求资助FASEB夏季研究会议（SRC）的部分支持，题为Kruppel样因子（KLF）的生物学和病理学。为期5天的会议是第一次在美国举行的关于这一主题的国际会议。S. Kruppel样因子是一个含锌指的转录因子家族，代表了一个快速发展的领域。自从该家族的第一个成员--红细胞Kr--被发现以来，|ppel样因子（EKLF或KLF 1），大约16年前，另外21个成员已被确定。研究表明，KLF在涉及心血管、消化、呼吸、血液和免疫系统的各种生理过程中以及在诸如癌症、肥胖、糖尿病和炎症状况等病理状态中发挥重要功能。最近的研究还表明KLF参与体细胞重编程为诱导性多能干细胞（iPS）和维持胚胎干细胞的多能性。拟议的专题讨论会旨在汇集KLF研究领域的一批国际领导人，目的是激发讨论和促进合作。基于KLF生物学的心血管、癌症、糖尿病和炎性疾病的治疗开发潜力是会议可能产生的一种明显的可能性。 会议的具体内容如下： a.提供KLF研究前沿的科学计划，围绕生理功能和疾病的器官病理生理学主题组织。 B.为KLF领域的研究人员提供有意义的交流场所，以促进基础和临床科学的互动和潜在合作。 C.提供一个科学平台，鼓励年轻的调查人员和受训人员积极参与。 D.为参与者提供一个教育论坛。 在会议结束时，我们将生成会议会谈的摘要，并设想会议将激发热烈的讨论和令人兴奋的新想法，以推动该领域的发展。我们还期望继续会议平台，并建立一个类似主题的半年期会议时间表。