Emory Epithelial Pathobiology Research Development Center

总体描述（由申请人提供）：埃默里上皮病理学研究开发中心成立于2003年6月，是NIDDK支持的四个新资助的消化系统疾病研究开发中心（DDRDCs）之一。该中心的目标是为一组高度专业化和互动的上皮生物学家和消化系统病理生物学家提供核心服务，旨在提高研究能力，促进新的研究方向，并促进研究人员之间的合作和互动。该中心支持的研究主要集中在消化道的上皮生物学和病理生物学，有三个首要主题：炎症/感染，增殖/分化和正常生理学。该中心有三个核心：（A）基因表达分析核心，（B）图像分析核心和（C）细胞培养核心。在过去的几年中，这些核心在埃默里大学以消化系统疾病为中心的研究项目的发展中发挥了至关重要的作用，并显着提高了中心成员的研究能力，这体现在他们出色的科学生产力上。在成立之初，该中心有9名常设调查员（正式成员）和5名初级调查员（初级成员），年度直接费用合计为2 965 972美元（其中55%由NIDDK提供支助）。到目前为止，该中心已发展成为一个由21名正式成员和8名初级成员组成的小组，横跨埃默里大学医学院的医学系（包括消化疾病，内分泌学，肾脏病学，肺和重症监护医学和传染病），病理学，生理学，外科学，儿科学和神经学，以及埃默里学院的生物学系。这一竞争性续期申请的年度董事费用总额为8，862，960美元，其中67.7%由NIDDK资助。因此，在不到4年的时间里，该中心的成员增加了一倍多，其基本赠款支持增加了近两倍。重要的是，自2003年以来，这组研究人员在同行评审期刊上共发表了441篇原创研究文章，其中100篇包含2名或2名以上的作者。此外，至少有124项已发表的工作使用了该中心提供的核心服务，其中大多数引用了该中心的贡献。该中心还收到了大量的财政支持，从该机构（院长办公室，医学和病理学的椅子，消化系统疾病的司），其中实施了一个非常成功的丰富计划，包括试点/可行性项目资助计划，研究研讨会系列，年度科学研讨会和咨询委员会会议，并定期通讯。因此，该中心的继续存在将进一步增强埃默里大学消化系统疾病研究的实力，并重点关注NIDDK支持的任务范围内的领域。

DESCRIPTION, OVERALL (provided by applicant): The Emory Epithelial Pathobiology Research Development Center was established in June of 2003 as one of four newly funded Digestive Diseases Research Development Centers (DDRDCs) supported by the NIDDK. The goal of the Center is to provide core services to a group of highly specialized and interactive epithelial biologists and pathobiologists in the digestive system with the intention of enhancing research capability, promoting new research directions, and fostering collaboration and interaction among the investigators. Research supported by the Center is mainly focused on epithelial biology and pathobiology of the digestive tract with three overarching themes: Inflammation/Infection, Proliferation/ Differentiation, and Normal Physiology. The Center has three cores: (A) Gene Expression Analysis Core, (B) Image Analysis Core, and (C) Cell Culture Core. In the past few years, these cores have played crucial roles in the development of a digestive diseases-centered research program at Emory and significantly enhanced the research capability of Center members as demonstrated by their outstanding scientific productivity. At its inception, the Center had 9 established investigators (full members) and 5 junior investigators (junior members) with a combined annual direct costs of $2,965,972 (55% of which supported by NIDDK). To date, the Center has evolved into a group of 21 full members and 8 junior members spanning across Departments of Medicine (including Divisions of Digestive Diseases, Endocrinology, Nephrology, Pulmonary & Critical Care Medicine, and Infectious Diseases), Pathology, Physiology, Surgery, Pediatrics, and Neurology in the Emory University School of Medicine, and Department of Biology in the Emory College. The combined annual director costs of this competing renewal application are $8,862,960, 67.7% of which are funded by the NIDDK. Thus, in less than 4 years, the Center has more than doubled its membership and nearly tripled its base grant support. Importantly, since 2003, this group of investigators collectively published 441 original research articles in peer-reviewed journals, out of which 100 contained 2 or more authors that are members of the Center. Moreover, at least 124 of these published work used core services provided by the Center, the majority of which cited the contribution of the Center. The Center has also received substantial amounts of financial support from the institution (Office of the Dean, Chairs of Medicine and Pathology, and Division of Digestive Diseases) with which to implement a highly successful enrichment program including a Pilot/Feasibility Project Grant Program, Research Seminar Series, Annual Scientific Symposium and Advisory Committee Meeting, and periodic Newsletters. The continuation of the Center will therefore further increase the strength of digestive diseases research at Emory with a strong focus on areas within the missions supported by the NIDDK.