FASEB Summer Research Conference: The Biology of Calpains in Health and Disease

FASEB 夏季研究会议：钙蛋白酶在健康和疾病中的生物学

• 批准号: 8004252
• 负责人: James W. Geddes
• 金额: $ 2.8万
• 依托单位: FEDERATION OF AMER SOC FOR EXPER BIOLOGY
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-07-15 至 2011-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8004252
• 关键词: Acute; Alzheimer' s Disease; Animals; Arizona; Binding; Biochemical; Biological Markers; Biology; Calpain; Cell Death; Diabetes Mellitus; Disease; Exercise; Funding; Future; Genomics; Growth; Health; Heart Hypertrophy; Housing; Individual; Injury; Institutes; Knock-out; Malaria; Membrane Proteins; Molecular Models; Muscle; Muscular Dystrophies; Myocardium; National Institute of Arthritis and Musculoskeletal and Skin Diseases; National Institute of Neurological Disorders and Stroke; Neoplasm Metastasis; Neurodegenerative Disorders; Neuronal Injury; Oncogenic; Parasitic infection; Parkinson Disease; Pathologic Processes; Pathway interactions; Peptide Hydrolases; Physiological; Process; Property; Protein Isoforms; Proteolysis; Proteomics; Regulation; Research; Research Personnel; Role; Schedule; Science; Skeletal Muscle; Structure; System; Therapeutic; Tissues; United States National Institutes of Health; authority; calpain inhibitor; calpastatin; cell transformation; inhibitor/antagonist; meetings; molecular modeling; overexpression; programs; protein degradation; public health relevance; skeletal; symposium

DESCRIPTION (provided by applicant): A FASEB summer research conference is planned for July 2010 entitled "Biology of Calpains in Health and Disease". This is the fifth such meeting focusing on calpains and it will be held in Carefree, Arizona. Funds are being requested from three NIH institutes that include NINDS as the primary, with NIA and NIAMS having kindly agreed to accept secondary assignments regarding this application. Funds obtained from these institutes will provide partial support for the meeting. The meeting this year will have two main emphases; 1) understanding the biochemical properties of calpains and 2) understanding the role of calpains in various disease processes. Ten stimulating sessions are planned for the meeting including 1) Proteolysis and Cell Death-Keynote talk by Dr. Doug Green, a leading authority on cell death pathways; 2) A Tribute to Darrel Goll and Calpains in Animal Science-Dr. Goll, who passed away in July 2008, was a leading investigator on calpains and muscle. He was the first to identify calpains and calpastatin in skeletal and cardiac muscle, and to identify the role of calpains in muscle growth; 3) Challenging the System-evaluating the impact of the knockout or overexpression of individual calpain isoforms or the inhibitor calpastatin; 4) Roles and Regulation-examining the physiological roles of calpains and regulation of calpain activity; 5) Aberrant Roles in Disease-Exploring the contributions of calpains to cardiac hypertrophy, Alzheimer's disease, Parkinson's disease, and parasitic infections including malaria; 6) Structure and Function- examining the molecular interactions and diverse roles of the muscle-predominant calpain 3 isoform, as well as the activation of calpains in skeletal muscle following exercise; 7) Injury and Biomarkers-discussing the roles of calpains and other proteases in neuronal injury; 8) Mechanisms and Inhibitors-the molecular modeling and interactions of calpains and inhibitors, as well as the function of calpain 7; 9) Unconventional Calpains-calpain 6, fungal calpain 7, and phytocalpain DEK1; and 10) Future Directions-proteomic identification of calpain substrates and a panel discussion on the future directions of calpain research. A meeting on the biology of the calpains is highly-relevant to the NIH because calpains are involved in both normal and pathological processes. The activities of the house- keeping calpains are important for normal protein turnover and processing of cytoskeletal and membrane proteins in all tissues. Calpain inhibition is a promising therapeutic for acute CNS insults, late-onset neurodegenerative disorders, some forms of muscular dystrophy, cardiac hypertrophy, oncogenic cell transformation and metastasis, diabetes, and several other disorders. Three years have passed since the last meeting on calpain and substantial progress on the genomics, structure activation and roles in disease have been made. The proposed program will provide the forum by which the momentum in this field may be maintained. PUBLIC HEALTH RELEVANCE: A fifth FASEB summer conference focused on the topic of calpains is scheduled for July 2010 which will feature the latest advances in calpain research on both normal and pathological processes including acute CNS insults, late-onset neurodegenerative disorders, some forms of muscular dystrophy, cardiac hypertrophy, oncogenic cell transformation and metastasis, diabetes, and several other disorders. These conferences are held every three years, and there has been considerable progress on the biology of calpains since the previous 2007 meeting.

描述（由申请人提供）：计划于 2010 年 7 月召开 FASEB 夏季研究会议，题为“健康与疾病中钙蛋白酶的生物学”。这是第五次关注钙蛋白酶的此类会议，它将在亚利桑那州的 Carefree 举行。正在向三个 NIH 机构申请资金，其中 NINDS 是主要机构，NIA 和 NIAMS 已同意接受有关此申请的次要任务。这些机构获得的资金将为会议提供部分支持。今年的会议将有两个重点： 1) 了解钙蛋白酶的生化特性，2) 了解钙蛋白酶在各种疾病过程中的作用。会议计划举办十场激动人心的会议，其中包括 1) 蛋白质水解和细胞死亡——细胞死亡途径领域权威 Doug Green 博士的主题演讲； 2) 向动物科学领域的达雷尔·戈尔 (Darrel Goll) 和卡尔潘斯 (Calpains) 致敬 - 博士。戈尔于 2008 年 7 月去世，他是钙蛋白酶和肌肉方面的主要研究者。他是第一个在骨骼肌和心肌中鉴定出钙蛋白酶和钙蛋白酶抑制素的人，并确定了钙蛋白酶在肌肉生长中的作用； 3) 挑战系统——评估个体钙蛋白酶亚型或抑制剂钙蛋白酶抑制剂的敲除或过度表达的影响； 4) 作用和调节——检查钙蛋白酶的生理作用和钙蛋白酶活性的调节； 5）疾病中的异常作用——探索钙蛋白酶对心脏肥大、阿尔茨海默病、帕金森病和包括疟疾在内的寄生虫感染的贡献； 6) 结构和功能——检查肌肉主导的钙蛋白酶 3 亚型的分子相互作用和不同作用，以及运动后骨骼肌中钙蛋白酶的激活； 7）损伤和生物标志物——讨论钙蛋白酶和其他蛋白酶在神经元损伤中的作用； 8）机制和抑制剂——钙蛋白酶和抑制剂的分子建模和相互作用，以及钙蛋白酶7的功能； 9）非常规钙蛋白酶——钙蛋白酶6、真菌钙蛋白酶7、植物钙蛋白酶DEK1； 10) 未来方向——钙蛋白酶底物的蛋白质组学鉴定以及关于钙蛋白酶研究未来方向的小组讨论。关于钙蛋白酶生物学的会议与 NIH 高度相关，因为钙蛋白酶参与正常和病理过程。管家钙蛋白酶的活性对于所有组织中细胞骨架和膜蛋白的正常蛋白质周转和加工都很重要。钙蛋白酶抑制是治疗急性中枢神经系统损伤、迟发性神经退行性疾病、某些形式的肌营养不良、心脏肥大、致癌细胞转化和转移、糖尿病和其他几种疾病的有前景的治疗方法。自上次关于钙蛋白酶的会议以来已经过去了三年，在基因组学、结构激活和疾病中的作用方面已经取得了实质性进展。拟议的计划将提供一个论坛，通过该论坛可以维持该领域的势头。 公共健康相关性：第五次 FASEB 夏季会议定于 2010 年 7 月举行，重点关注钙蛋白酶主题，会议将重点介绍钙蛋白酶在正常和病理过程方面的研究最新进展，包括急性中枢神经系统损伤、迟发性神经退行性疾病、某些形式的肌营养不良、心脏肥大、致癌细胞转化和转移、糖尿病和其他几种疾病。这些会议每三年举行一次，自 2007 年上一次会议以来，钙蛋白酶生物学已经取得了相当大的进展。