FASEB Summer Research Conference: The Biology of Calpains in Health and Disease

描述（由申请人提供）：FASEB夏季研究会议计划于2010年7月举行，题为“Calpains在健康和疾病中的生物学”。这是第五次这样的会议集中在钙蛋白酶，它将在无忧无虑，亚利桑那州举行。目前正在向包括NINDS在内的三个NIH研究所申请资金，NIA和NIAMS已同意接受有关此应用程序的次要任务。从这些机构获得的资金将为会议提供部分支助。今年的会议将有两个主要重点：1）了解钙蛋白酶的生物化学性质和2）了解钙蛋白酶在各种疾病过程中的作用。会议计划举办10场刺激性会议，包括1）蛋白水解和细胞死亡-细胞死亡途径的主要权威Doug绿色博士的主题演讲; 2）向动物科学中的Darrel Goll和Calpains致敬-Goll博士于2008年7月去世，是Calpains和肌肉的主要研究者。他是第一个鉴定骨骼肌和心肌中的钙蛋白酶和钙蛋白酶抑制剂，并确定钙蛋白酶在肌肉生长中的作用; 3）系统分析-评估单个钙蛋白酶异构体或抑制剂钙蛋白酶抑制剂的敲除或过表达的影响; 4）作用和调节-检查钙蛋白酶的生理作用和钙蛋白酶活性的调节; 5）疾病中的异常作用-探索钙蛋白酶对心脏肥大、阿尔茨海默病、帕金森病和寄生虫感染（包括疟疾）的贡献; 6）结构和功能-检查肌肉主导的钙蛋白酶3同种型的分子相互作用和不同作用，7）损伤与生物标志物--讨论钙蛋白酶和其他蛋白酶在神经元损伤中的作用; 8）机制与抑制剂--钙蛋白酶和抑制剂的分子模拟和相互作用，以及钙蛋白酶7的功能; 9）非常规钙蛋白酶-钙蛋白酶6，真菌钙蛋白酶7，和植物钙蛋白酶DEK 1;和10）未来的方向-钙蛋白酶底物的蛋白质组学鉴定和钙蛋白酶研究的未来方向的小组讨论。关于钙蛋白酶生物学的会议与NIH高度相关，因为钙蛋白酶参与正常和病理过程。管家钙蛋白酶的活性对于所有组织中正常的蛋白质周转和细胞骨架和膜蛋白的加工是重要的。钙蛋白酶抑制是一种有前途的治疗急性中枢神经系统损伤，迟发性神经退行性疾病，一些形式的肌营养不良症，心脏肥大，致癌细胞转化和转移，糖尿病，和其他几种疾病。自上一次calpain会议以来，已经过去了三年，在基因组学、结构激活和疾病中的作用等方面取得了实质性进展。拟议的方案将提供一个论坛，通过这个论坛可以保持这一领域的势头。 公共卫生相关性：FASEB第五届夏季会议将于2010年7月举行，会议将重点讨论钙蛋白酶的主题，并将介绍钙蛋白酶在正常和病理过程中的最新研究进展，包括急性中枢神经系统损伤、迟发性神经退行性疾病、某些形式的肌营养不良、心脏肥大、致癌细胞转化和转移、糖尿病和其他几种疾病。这些会议每三年举行一次，自2007年的上一次会议以来，钙蛋白酶的生物学已经取得了相当大的进展。

DESCRIPTION (provided by applicant): A FASEB summer research conference is planned for July 2010 entitled "Biology of Calpains in Health and Disease". This is the fifth such meeting focusing on calpains and it will be held in Carefree, Arizona. Funds are being requested from three NIH institutes that include NINDS as the primary, with NIA and NIAMS having kindly agreed to accept secondary assignments regarding this application. Funds obtained from these institutes will provide partial support for the meeting. The meeting this year will have two main emphases; 1) understanding the biochemical properties of calpains and 2) understanding the role of calpains in various disease processes. Ten stimulating sessions are planned for the meeting including 1) Proteolysis and Cell Death-Keynote talk by Dr. Doug Green, a leading authority on cell death pathways; 2) A Tribute to Darrel Goll and Calpains in Animal Science-Dr. Goll, who passed away in July 2008, was a leading investigator on calpains and muscle. He was the first to identify calpains and calpastatin in skeletal and cardiac muscle, and to identify the role of calpains in muscle growth; 3) Challenging the System-evaluating the impact of the knockout or overexpression of individual calpain isoforms or the inhibitor calpastatin; 4) Roles and Regulation-examining the physiological roles of calpains and regulation of calpain activity; 5) Aberrant Roles in Disease-Exploring the contributions of calpains to cardiac hypertrophy, Alzheimer's disease, Parkinson's disease, and parasitic infections including malaria; 6) Structure and Function- examining the molecular interactions and diverse roles of the muscle-predominant calpain 3 isoform, as well as the activation of calpains in skeletal muscle following exercise; 7) Injury and Biomarkers-discussing the roles of calpains and other proteases in neuronal injury; 8) Mechanisms and Inhibitors-the molecular modeling and interactions of calpains and inhibitors, as well as the function of calpain 7; 9) Unconventional Calpains-calpain 6, fungal calpain 7, and phytocalpain DEK1; and 10) Future Directions-proteomic identification of calpain substrates and a panel discussion on the future directions of calpain research. A meeting on the biology of the calpains is highly-relevant to the NIH because calpains are involved in both normal and pathological processes. The activities of the house- keeping calpains are important for normal protein turnover and processing of cytoskeletal and membrane proteins in all tissues. Calpain inhibition is a promising therapeutic for acute CNS insults, late-onset neurodegenerative disorders, some forms of muscular dystrophy, cardiac hypertrophy, oncogenic cell transformation and metastasis, diabetes, and several other disorders. Three years have passed since the last meeting on calpain and substantial progress on the genomics, structure activation and roles in disease have been made. The proposed program will provide the forum by which the momentum in this field may be maintained. PUBLIC HEALTH RELEVANCE: A fifth FASEB summer conference focused on the topic of calpains is scheduled for July 2010 which will feature the latest advances in calpain research on both normal and pathological processes including acute CNS insults, late-onset neurodegenerative disorders, some forms of muscular dystrophy, cardiac hypertrophy, oncogenic cell transformation and metastasis, diabetes, and several other disorders. These conferences are held every three years, and there has been considerable progress on the biology of calpains since the previous 2007 meeting.