Neurobiology of CNS Injury and Repair

描述（由申请人提供）： 项目摘要/摘要 这是一项新的 T32 申请，要求为每年 4 名博士前研究员的中枢神经系统损伤和修复神经生物学培训计划提供资金。博士前研究员的培训将由肯塔基大学脊髓和脑损伤研究中心（SCoBIRC）的培训教师进行。拟议项目的总体目标是提供关于 SCI 和 TBI 的急性、亚急性和慢性病理生理学的现代研究概念的广泛培训，以及识别潜在的疾病缓解分子靶点，这些靶点可以推动药理学和基因治疗策略的发现，从而改善这些损伤的破坏性影响。这些策略将包括“神经保护”和“神经恢复”方法。尽管预计大多数学员将从事基于实验室的治疗发现研究的职业，但他们还将接受目标神经系统疾病的临床方面以及神经系统临床试验的设计和进行中涉及的实际问题的培训。为了实现这一目标，博士前研究员还将在一个学期中每周花一天的时间跟踪神经病学、神经外科和/或神经康复临床教师，并参加每周的大型查房，以了解他们研究重点的 TBI 和 SCI 的临床性质。这将增强他们作为独立研究人员的未来能力，不仅能够在实验损伤模型中做出治疗发现，而且还为他们提供有关如何设计基础研究的知识，以便更容易地将有前途的治疗方法转化为临床研究和治疗试验。

DESCRIPTION (provided by applicant): PROJECT SUMMARY/ABSTRACT This is a new T32 application requesting funding for a Neurobiology of CNS Injury and Repair Training Program for 4 predoctoral fellows/year. The training of the predoctoral fellows will be carried out by training faculty in the University of Kentucky Spinal Cord & Brain Injury Research Center (SCoBIRC). The overall goal of the proposed program is to provide broad-based training in modern research concepts regarding the acute, subacute and chronic pathophysiology of SCI and TBI and the identification of potential disease-modifying molecular targets that can drive the discovery of pharmacological and gene therapeutic strategies by which the devastating effects of these injuries can be ameliorated. These strategies will include both "neuroprotective" and "neurorestorative" approaches. Although it is anticipated that most of the trainees will pursue careers in laboratory-based therapeutic discovery research, they will also receive training in clinical aspects of the targeted neurological disorders and the practical issues involved in the design and conduct of neurological clinical trials. To accomplish this, the predoctoral fellows wil also spend one day/week for a semester shadowing neurological, neurosurgical and/or neurorehabilitation clinical faculty, and attending weekly grand rounds to gain an understanding of the clinical nature of TBI and SCI that their research is focused upon. This will enhance their future ability as independent investigators to not only make therapeutic discoveries in experimental injury models, but also provide them with knowledge concerning how to design their basic research in a manner that will more readily enable the translation of promising therapeutic approaches into clinical studies and therapeutic trials.