FASEB SRC on The Biology of Calpains in Health and Disease

FASEB SRC 关于钙蛋白酶在健康和疾病中的生物学

• 批准号: 8597743
• 负责人: James W. Geddes
• 金额: $ 2.2万
• 依托单位: FEDERATION OF AMER SOC FOR EXPER BIOLOGY
• 依托单位国家: 美国
• 财政年份: 2013
• 资助国家: 美国
• 起止时间: 2013-07-01 至 2014-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8597743
• 关键词: Academy; Aging; Alzheimer' s Disease; Amyotrophic Lateral Sclerosis; Area; Atrial Fibrillation; Autophagocytosis; Biochemical; Bioinformatics; Biological Process; Biology; Brain Injuries; Calpain; Cardiac; Cardiovascular Diseases; Cell Death; Cell Differentiation process; Cell secretion; Cerebral Ischemia; Child Care; Colon Carcinoma; Cytoskeletal Proteins; Diabetes Mellitus; Discipline; Disease; Embryo; Family; Funding; Genomics; Goals; Health; Heart Hypertrophy; Housekeeping; Human; Individual; Injury; Institutes; Knock-out; Machado-Joseph Disease; Malaria; Malignant Neoplasms; Measures; Membrane Proteins; Minority; Muscle; Muscular Dystrophies; Mutation; National Heart, Lung, and Blood Institute; National Institute of Arthritis and Musculoskeletal and Skin Diseases; National Institute of Diabetes and Digestive and Kidney Diseases; National Institute of Neurological Disorders and Stroke; Nerve Degeneration; Normal Cell; Normal tissue morphology; Participant; Pathogenesis; Pathologic Processes; Pathway interactions; Play; Process; Property; Protein Isoforms; Recruitment Activity; Research; Research Personnel; Rivers; Role; Schedule; Schools; Scientist; Seminal; Signal Transduction; Site; Societies; Stroke; Structure; Therapeutic; Tissues; Traumatic Brain Injury; United States National Institutes of Health; Update; Vascular remodeling; Vermont; Woman; Work; Wound Healing; abstracting; calpain inhibitor; calpastatin; cell motility; design; inhibitor/antagonist; interest; meetings; programs; protein degradation; public health relevance; symposium

DESCRIPTION (provided by applicant): A FASEB summer conference is planned for July 2013 entitled "Biology of Calpains in Health and Disease". This is the sixth such meeting focusing on calpains and it will be held in Saxton Rivers, Vermont. Funds are being requested from six different NIH institutes, with NINDS as the primary and NCI, NHLBI, NIA, NIDDK, and NIAMS as secondary assignments. Funds obtained from these institutes will provide partial support for the meeting. The meeting will have two main emphases; 1) understanding the biochemical properties of calpains and 2) understanding the role of calpains in various disease processes. Eight stimulating sessions are planned for the meeting including 1) Bioinformatics of Calpain Substrates, 2) Calpains and Cancer, 3) Measuring Calpain Activation 3) Calpains in Cell Death Pathways 4) Calpains in Diabetes, 5) Calpains in Neurodegeneration and Brain Injury 6) Calpains in Cardiovascular Disease 7) Calpain inhibitors as therapeutics, and 8) Calpains in Muscle. Dr. Peter Davies will be the keynote speaker. Dr. Davies has made seminal contributions to our understanding of the structure of calpain as well as the mechanism of action of the endogenous calpain inhibitor, calpastatin. A meeting on the biology of the calpains is highly-relevant to the NIH because calpains are involved in both normal and pathological processes. The activities of the house- keeping calpains are important for normal protein turnover and processing of cytoskeletal and membrane proteins in all tissues. Mutations in calpains or in calpain substrates are associated with disease and lethality. Disorders discussed at the this meeting will include aging, Alzheimer's disease, amyotrophic lateral sclerosis, atrial fibrillation, cardiac ischemic injury, cerebral ischemia, cardiac hypertrophy, diabetes, Machado-Joseph disease, malaria, muscular dystrophy, stroke, traumatic brain injury, and vascular remodeling. Three years have passed since the last meeting on calpain and substantial progress on the genomics, structure, activation and roles in disease have been made. The proposed program will provide the forum by which the momentum in this field may be maintained.

描述（由申请人提供）： FASEB夏季会议计划于2013年7月举行，题为“健康和疾病中的钙蛋白酶生物学”。这是第六次这样的会议，重点是钙蛋白酶，它将在萨克斯顿河流，佛蒙特州举行。目前正在向六个不同的NIH研究所申请资金，NINDS是主要任务，NCI、NHLBI、NIA、NIDDK和NIAMS是次要任务。从这些机构获得的资金将为会议提供部分支助。会议将有两个主要重点; 1）了解钙蛋白酶的生化特性和2）了解钙蛋白酶在各种疾病过程中的作用。会议计划举办八场激动人心的会议，包括1）钙蛋白酶底物的生物信息学，2）钙蛋白酶和癌症，3）测量钙蛋白酶激活3）细胞死亡途径中的钙蛋白酶4）钙蛋白酶在糖尿病中，5）钙蛋白酶在神经退行性疾病和脑损伤中6）钙蛋白酶在心血管疾病中7）钙蛋白酶抑制剂作为治疗剂，以及8）肌肉中的钙蛋白酶。彼得·戴维斯博士将是主讲人。Davies博士对我们理解钙蛋白酶的结构以及内源性钙蛋白酶抑制剂钙蛋白酶抑制剂的作用机制做出了开创性的贡献。关于钙蛋白酶生物学的会议与NIH高度相关，因为钙蛋白酶参与正常和病理过程。管家钙蛋白酶的活性对于所有组织中正常的蛋白质周转和细胞骨架和膜蛋白的加工是重要的。钙蛋白酶或钙蛋白酶底物的突变与疾病和致死性有关。在这次会议上讨论的疾病将包括衰老，阿尔茨海默氏病，肌萎缩侧索硬化症，心房纤颤，心脏缺血性损伤，脑缺血，心脏肥大，糖尿病，Machado-Joseph病，疟疾，肌肉萎缩症，中风，创伤性脑损伤和血管重塑。自上一次关于钙蛋白酶的会议以来，已经过去了三年，在基因组学、结构、激活及其在疾病中的作用方面取得了实质性进展。拟议的方案将提供一个论坛，通过这个论坛可以保持这一领域的势头。