Neurobiology of CNS Injury and Repair

项目简介/摘要：这是一项新的T32申请，为CNS损伤和修复神经生物学培训计划申请资金，4名博士前研究员/年。博士前研究员的培训将由肯塔基大学脊髓与脑损伤研究中心（SCoBIRC）的培训教师进行。该计划的总体目标是提供有关SCI和TBI的急性、亚急性和慢性病理生理的现代研究概念的广泛培训，并确定潜在的疾病修饰分子靶点，这些靶点可以推动发现药理学和基因治疗策略，通过这些策略可以改善这些损伤的破坏性影响。这些策略将包括“神经保护”和“神经恢复”两种方法。虽然预计大多数受训者将从事以实验室为基础的治疗发现研究，但他们也将接受针对神经系统疾病的临床方面的培训，以及涉及设计和实施神经系统临床试验的实际问题。为了实现这一目标，博士前研究员还将在一个学期中花一天/一周的时间跟随神经学、神经外科和/或神经康复临床教员，并参加每周的大查班，以了解他们研究重点的TBI和SCI的临床性质。这将提高他们未来作为独立研究者的能力，不仅可以在实验损伤模型中发现治疗性发现，还可以为他们提供有关如何设计基础研究的知识，从而更容易地将有希望的治疗方法转化为临床研究和治疗试验。

DESCRIPTION (provided by applicant): PROJECT SUMMARY/ABSTRACT This is a new T32 application requesting funding for a Neurobiology of CNS Injury and Repair Training Program for 4 predoctoral fellows/year. The training of the predoctoral fellows will be carried out by training faculty in the University of Kentucky Spinal Cord & Brain Injury Research Center (SCoBIRC). The overall goal of the proposed program is to provide broad-based training in modern research concepts regarding the acute, subacute and chronic pathophysiology of SCI and TBI and the identification of potential disease-modifying molecular targets that can drive the discovery of pharmacological and gene therapeutic strategies by which the devastating effects of these injuries can be ameliorated. These strategies will include both "neuroprotective" and "neurorestorative" approaches. Although it is anticipated that most of the trainees will pursue careers in laboratory-based therapeutic discovery research, they will also receive training in clinical aspects of the targeted neurological disorders and the practical issues involved in the design and conduct of neurological clinical trials. To accomplish this, the predoctoral fellows wil also spend one day/week for a semester shadowing neurological, neurosurgical and/or neurorehabilitation clinical faculty, and attending weekly grand rounds to gain an understanding of the clinical nature of TBI and SCI that their research is focused upon. This will enhance their future ability as independent investigators to not only make therapeutic discoveries in experimental injury models, but also provide them with knowledge concerning how to design their basic research in a manner that will more readily enable the translation of promising therapeutic approaches into clinical studies and therapeutic trials.