Lipid Droplets: Metabolic Consequences of the Storage of Neutral Lipids

描述（由申请人提供）：肥胖症和相关病理（如胰岛素抵抗、糖尿病和心血管疾病）的流行促使了对脂质储存和代谢生物学的研究激增。阐明脂滴生物发生、储存、运输、脂解和氧化等基本过程对于设计代谢紊乱的新治疗策略至关重要。本次会议的脂滴：中性脂质储存的代谢后果将汇集来自众多学科的科学家，以定义，描述和分析关键的科学问题和细胞生物学，生物化学和脂滴生理学的最新进展。2007年举行了关于这一主题的首次会议，并受到了极大的热情。从那时起，脂滴领域呈指数级增长;事实上，PubMed中使用术语“脂滴”的出版物中有25%是从2008年至今出现的。因此，召开一次关于这一议题的会议的动力从未如此之大。这次会议将汇集科学家在这个新兴领域的不同和不同方面的工作，但谁没有参加过相同的会议，以产生新的想法，方法和合作的目标。小型会议形式和隐蔽的会议场地将培养一个亲密和互动的环境，其中初级研究人员，包括研究生，博士后研究员和初级教师，将有充分的机会与更资深的研究人员互动。 本申请要求部分资金，以支持10名研究生和博士后研究员参加将于2010年7月25日至7月30日在科罗拉多汽船泉举行的会议。形式将包括开幕之夜的主旨演讲和九次与受邀演讲者的会谈，以及从提交的摘要中选择的几次额外的简短会谈。会议主题包括：1）脂滴的结构和行程，2）脂滴细胞生物学中的新参与者，3）脂滴生物发生，4）脂质底物的递送和代谢，5）脂滴周转，6）中性脂质合成和代谢，7）健康和疾病中的肝脏脂质储存，8）致病过程中的脂滴，以及9）脂肪酸通量中的脂滴。两个为期2天的海报会议，以及从摘要中选择的简短演讲，将允许更多的研究人员，包括研究生和博士后研究员，介绍他们的研究。 公共卫生相关性：本次会议将汇集脂质生物化学，细胞生物学和生物生理学的专家，从酵母和植物到小鼠和人类，讨论脂滴的生物学。脂肪细胞、肝脏、肌肉和心脏等组织中脂滴的开发和利用是肥胖症、2型糖尿病、动脉粥样硬化和代谢综合征等疾病的关键过程。因此，更好地了解脂滴形成，动力学和营业额将提供新的信息，可用于影响这些疾病的发展。

DESCRIPTION (provided by applicant): The prevalence of obesity and associated pathologies such as insulin resistance, diabetes, and cardiovascular disease has prompted an explosion of research on the biology of lipid storage and metabolism. The elucidation of fundamental processes such as lipid droplet biogenesis, storage, trafficking, lipolysis, and oxidation is critical in designing new therapeutic strategies for metabolic disorders. This conference on Lipid Droplets: Metabolic Consequences of the Storage of Neutral Lipids will bring together scientists from numerous disciplines for the purpose of defining, describing, and analyzing critical scientific problems and recent advances in the cell biology, biochemistry, and physiology of lipid droplets. The inaugural conference on this topic occurred in 2007 and was met with extreme enthusiasm. Since then, the lipid droplet field has grown exponentially; indeed, 25% of the publications listed in PubMed using the term 'lipid droplet' have appeared from 2008 to present. Thus, the impetus for a meeting on this topic has never been greater. This meeting will bring together scientists working on diverse and varied aspects of this emerging field, but who have not previously attended the same conferences, with the goal of generating new ideas, approaches, and collaborations. The small conference format and secluded conference site will foster an intimate and interactive environment in which junior investigators, including graduate students, postdoctoral fellows, and junior faculty, will have ample opportunity to interact with more senior established investigators. This application requests partial funding to support the participation of 10 graduate students and postdoctoral fellows at the conference to be held July 25 - July 30, 2010 at Steamboat Springs, Colorado. The format will include an opening night Keynote Address and nine sessions of talks with invited speakers and several additional short talks to be selected from submitted abstracts. The session topics include: 1) The architecture and itinerary of lipid droplets, 2) New players in lipid droplet cell biology, 3) Lipid droplet biogenesis, 4) Delivery and metabolism of lipid substrates, 5) Lipid droplet turnover, 6) Neutral lipid synthesis and metabolism, 7) Hepatic lipid storage in health and disease, 8) Lipid droplets in pathogenic processes, and 9) Lipid droplets in fatty acid flux. Two 2-day poster sessions, as well as the short talks to be selected from abstracts, will allow additional investigators, including graduate students and postdoctoral fellows, to present their research. PUBLIC HEALTH RELEVANCE: Project Narrative This conference will bring together experts in lipid biochemistry, cell biology, and physiology of organisms ranging from yeast and plant to mouse and man to discuss the biology of lipid droplets. The development and utilization of lipid droplets in tissues such as fat cells, liver, muscle and heart, are key processes in disorders such as obesity, type 2 diabetes, atherosclerosis, and metabolic syndrome. Thus, a better understanding of lipid droplet formation, dynamics, and turnover will provide new information that may be used to impact the development of these disorders.