Genetics 2010: Model Organisms to Human Biology

描述（由申请人提供）：这是一份申请，支持由美国遗传学会（GSA）主办的题为“遗传学2010：人类生物学模式生物”的会议，该会议将于2010年6月12日至15日在马萨诸塞州波士顿举行。GSA认为，在这个时代，召开一次会议将研究模式生物的研究人员与研究人类生物学和疾病的研究人员聚集在一起是很重要的。这种结合促进了一个充满活力的论坛，以便在通常不互动的科学家之间交流结果和思想。模式生物的研究为我们现代对人类生物学的理解提供了基础，从阐明转录调控机制到为复杂人类特征的全基因组关联研究提供基础的发现。此外，这些研究，以及最近的基因组测序项目，已经揭示了生物体在细胞生长的大多数基本方面高度保守的显著程度，以及模式生物研究如何与理解人体组织发育，生理学和病理学直接相关。然而，我们仍然需要学习如何在整个系统发育的范围内最好地应用模式生物来解决进化已经适合它们的人类生物学问题。这些挑战需要生物学家之间的积极讨论，他们通常在不同的圈子里活动。我们认为，这次会议填补了科学界现有资料的一个重大空白。我们也相信，这次会议可以成为美国国立卫生研究院鼓励的跨学科倡议的催化剂，许多人认为这是生物学和医学未来进步的源泉。每次会议将包括四名受邀演讲者（由联合主席选择），分为主要以模式生物为重点或以人类/哺乳动物为重点的演讲者。此外，将从提交的摘要中选择两个较短的演讲，为年轻的研究人员提供展示他们工作的机会，并使其能够包括特别感兴趣的最新新闻。最后，将有三位世界知名科学家（Jeremy Berg， Carol Greider和Gary Ruvkun）的主题演讲。此次会议预计将吸引约500人参加。它将在波士顿后湾区的波士顿喜来登酒店举行。除当地科学家外，所有与会者都将被安置在现场，并将一起用餐，以最大限度地刺激他们之间的互动。酒店对残疾人开放，并努力鼓励妇女和代表性不足的少数民族参与。会议的收费结构旨在鼓励年轻科学家的参与。

DESCRIPTION (provided by applicant): This is an application for support of a conference sponsored by the Genetics Society of America (GSA) entitled "Genetics 2010: Model Organisms to Human Biology", to be held in Boston, MA on June 12-15, 2010. The GSA believes that in this age it is important to convene a meeting that brings together investigators who study model organisms with investigators who study human biology and disease. This combination promotes a dynamic forum for the exchange of results and ideas between scientists who do not normally interact. Research on model organisms has provided the foundation for our modern-day understanding of human biology, ranging from elucidating the mechanisms for transcriptional regulation to the discoveries that provided the basis for genome-wide association studies of complex human traits. Moreover, these studies, along with more recent genome sequencing projects, have revealed the remarkable extent to which organisms are highly conserved for most fundamental aspects of cellular growth, and how model organism research is directly relevant to understanding human tissue development, physiology, and pathology. However, we still need to learn how best to apply model organisms across the entire spectrum of phylogeny to those problems of human biology for which evolution has suited them. These challenges require active discussion among biologists who normally move in different circles. We believe this meeting fills a significant gap in what is available to the scientific community. We also believe that this meeting can act as a catalyst for the type of interdisciplinary initiatives that the NIH encourages and that many see as a source of future advances in biology and medicine. Each session will include four invited speakers (chosen by the co-chairs) divided between those with a primarily model organism focus or a human/mammalian focus. In addition, two shorter talks will be chosen from the submitted abstracts, to provide opportunities for younger investigators to present their work and to enable inclusion of late-breaking stories of special interest. Finally, there will be three keynote talks by world renowned scientists (Jeremy Berg, Carol Greider, and Gary Ruvkun). The meeting is expected to attract approximately 500 people. It will be held at the Boston Sheraton in the Back Bay section of Boston. All meeting attendees, except local scientists, will be housed on-site and will take most meals together, to stimulate maximal interaction among them. The hotel is accessible to the handicapped and efforts have been made to encourage participation of women and under-represented minorities. The fee structure for the meeting is designed to encourage participation of young scientists. PUBLIC HEALTH RELEVANCE: Progress in understanding human disease and in developing treatments often comes from developing more easily studied animal models. Genomics has taught us that many important disease processes take place in a much wider group of animals and model organisms than was previously known. This meeting will teach participants how to find and exploit the ideal model system in which to increase our understanding of the particular disease or process that they study.