Genetics and Genomics PhD Training Grant

描述（由申请人提供）：这是一份新的申请，用于支持12名哈佛医学院遗传学和基因组学（PGG）博士课程第二年的研究生。这个项目的目标是为我们的学生提供全面和严格的遗传学训练，包括遗传和基因组数据的定量分析。这种训练来自于课程作业、项目活动和论文研究。学生们有机会在几个实验室中的一个进行博士研究，这些实验室以遗传学系为中心，但不限于遗传学系。培训资助学院的实验室涵盖广泛的研究领域，从原核基因调控到人类生物学和疾病。获得培训资助的学生是生物和生物医学科学（BBS）计划的一部分，这是一个包括六个部门的大型伞形计划。然而，PGG学生参加的项目与其他BBS学生不同，其重点是遗传学和基因组学。PGG的学生是根据他们在研究生院第一年对项目的兴趣和他们对论文实验室的选择来自主选择项目的。该项目要求学生将课程集中在遗传学和基因组学上，包括生物数据定量分析的课程。我们的学生将在PGG的指导老师的指导下选择课程和轮岗。PGG学生还将参加一系列计划活动，包括(1)年度秋季研讨会，(2)每月会议，让他们谈论自己的研究，与高年级学生互动，与博士后互动，包括那些研究临床遗传学的人，(3)每年有机会邀请并主持两位外部研讨会演讲者。学生将通过他们的论文咨询委员会对博士学位的进展进行监控，除了论文顾问外，该委员会还将包括至少一名PGG教员。此外，学生将撰写摘要，并在我们的年度研讨会上以海报或演讲的形式展示他们的作品。综上所述，该培训计划将为我们的学生提供出色的培训，使他们成为遗传学和基因组学领域高效的独立研究者。

DESCRIPTION (provided by applicant): This is a new application to support 12 graduate students in their second year of a Ph.D. Program in Genetics and Genomics (PGG) at Harvard Medical School. The goal of this program is to provide our students with comprehensive and rigorous training in genetics, including quantitative analysis of genetic and genomic data. This training comes from coursework, program activities, and dissertation research. The students have the opportunity to carry out Ph.D. research in one of several laboratories, centered around, but not exclusive to, the Department of Genetics. The laboratories of training grant faculty cover a wide range of research areas, ranging from prokaryotic gene regulation to human biology and disease. Students supported by the training grant are part of the Biological and Biomedical Sciences (BBS) program, a large umbrella program that includes six departments. However, PGG students participate in a program that is distinct from the rest of BBS students in its focus on genetics and genomics. PGG students are self-selected for the program based on their expressed interest in the program during their first year of graduate school and their choice of dissertation laboratory. Students in the program are required to concentrate their course work in genetics and genomics, including a requirement to take a course in the quantitative analysis of biological data. Our students will be guided in choosing courses and rotations by faculty advisors who are part of the PGG. PGG students will also participate in a set of programmatic activities, including (1) an annual fall symposium, (2) monthly meetings that will allow them to talk about their own research, to interact with senior students, and to interact with postdocs, including those studying clinical genetics, and (3) the opportunity to invite and host two outside seminar speakers each year. Students will be monitored for progress towards a Ph.D. by their dissertation advisory committees, which will include, in addition to the dissertation advisor, at least one PGG faculty member. Furthermore, students will write abstracts and present their work by either a poster or a talk at our annual symposium. Taken together, this training plan should provide outstanding training for our students to become highly productive independent investigators in the areas of genetics and genomics. PUBLIC HEALTH RELEVANCE: Many human diseases, including diabetes, cancer, and heart disease are caused by genetic factors that are inherited from one generation to the next. However, our understanding of how genetics contributes to most diseases is poor and requires further research. Our research training program will teach Ph.D. students in the most modern areas of genetics so that they can apply their knowledge to advance our understanding in the areas of human biology and disease.