Genetics and Genomics PhD Training Grant

描述(由申请人提供)：这是一个新的申请，以支持12名研究生在哈佛医学院遗传学和基因组学(PGG)博士项目的第二年。这个项目的目标是为我们的学生提供全面和严格的遗传学培训，包括对遗传和基因组数据的定量分析。这种培训来自于课程作业、项目活动和论文研究。学生们有机会在几个实验室中的一个进行博士研究，这些实验室以遗传学系为中心，但不是唯一的。培训资助教师的实验室涵盖了广泛的研究领域，从原核生物基因调控到人类生物学和疾病。由培训补助金支持的学生是生物和生物医学科学(BBS)计划的一部分，该计划是一个大型伞形计划，包括六个系。然而，PGG学生参加的项目与其他论坛学生不同的是，该项目的重点是遗传学和基因组学。PGG学生是根据他们在研究生院第一年表达的对该项目的兴趣和他们对论文实验室的选择来选择该项目的。该项目要求学生集中学习遗传学和基因组学，包括选修一门生物数据定量分析课程。我们的学生将在教师顾问的指导下选择课程和轮换，他们是PGG的一部分。PGG学生还将参加一系列计划活动，包括(1)一年一度的秋季研讨会，(2)每月举行的会议，让他们谈论自己的研究，与高年级学生互动，并与包括临床遗传学专业的博士后互动，以及(3)每年邀请和主持两名外部研讨会演讲者的机会。他们的学位论文顾问委员会将监督学生攻读博士学位的进展情况，该委员会除了学位论文导师外，还将包括至少一名PGG教职员工。此外，学生将撰写摘要，并在我们的年度研讨会上以海报或演讲的形式展示他们的作品。总而言之，这一培训计划应该会为我们的学生提供出色的培训，使他们成为遗传学和基因组学领域的高生产率独立研究人员。 与公共卫生相关：许多人类疾病，包括糖尿病、癌症和心脏病，都是由遗传因素引起的，这些遗传因素是代代相传的。然而，我们对遗传如何导致大多数疾病的理解很差，需要进一步研究。我们的研究培训计划将教授最现代的遗传学领域的博士生，这样他们就可以应用他们的知识来促进我们对人类生物学和疾病领域的理解。

DESCRIPTION (provided by applicant): This is a new application to support 12 graduate students in their second year of a Ph.D. Program in Genetics and Genomics (PGG) at Harvard Medical School. The goal of this program is to provide our students with comprehensive and rigorous training in genetics, including quantitative analysis of genetic and genomic data. This training comes from coursework, program activities, and dissertation research. The students have the opportunity to carry out Ph.D. research in one of several laboratories, centered around, but not exclusive to, the Department of Genetics. The laboratories of training grant faculty cover a wide range of research areas, ranging from prokaryotic gene regulation to human biology and disease. Students supported by the training grant are part of the Biological and Biomedical Sciences (BBS) program, a large umbrella program that includes six departments. However, PGG students participate in a program that is distinct from the rest of BBS students in its focus on genetics and genomics. PGG students are self-selected for the program based on their expressed interest in the program during their first year of graduate school and their choice of dissertation laboratory. Students in the program are required to concentrate their course work in genetics and genomics, including a requirement to take a course in the quantitative analysis of biological data. Our students will be guided in choosing courses and rotations by faculty advisors who are part of the PGG. PGG students will also participate in a set of programmatic activities, including (1) an annual fall symposium, (2) monthly meetings that will allow them to talk about their own research, to interact with senior students, and to interact with postdocs, including those studying clinical genetics, and (3) the opportunity to invite and host two outside seminar speakers each year. Students will be monitored for progress towards a Ph.D. by their dissertation advisory committees, which will include, in addition to the dissertation advisor, at least one PGG faculty member. Furthermore, students will write abstracts and present their work by either a poster or a talk at our annual symposium. Taken together, this training plan should provide outstanding training for our students to become highly productive independent investigators in the areas of genetics and genomics. PUBLIC HEALTH RELEVANCE: Many human diseases, including diabetes, cancer, and heart disease are caused by genetic factors that are inherited from one generation to the next. However, our understanding of how genetics contributes to most diseases is poor and requires further research. Our research training program will teach Ph.D. students in the most modern areas of genetics so that they can apply their knowledge to advance our understanding in the areas of human biology and disease.