Genetics and Genomics PhD Training Grant

描述（由申请人提供）：这是一个新的应用程序，以支持12名研究生在他们的第二年的博士学位。哈佛医学院遗传学和基因组学（PGG）课程。该计划的目标是为我们的学生提供全面而严格的遗传学培训，包括遗传和基因组数据的定量分析。这种培训来自课程，计划活动和论文研究。学生有机会进行博士学位。研究在几个实验室之一，围绕，但不限于，遗传学系。培训补助金学院的实验室涵盖广泛的研究领域，从原核基因调控到人类生物学和疾病。由培训补助金支持的学生是生物和生物医学科学（BBS）计划的一部分，这是一个包括六个部门的大型伞式计划。然而，PGG的学生参加了一个程序，这是从BBS的学生在其重点遗传学和基因组学的休息不同。PGG学生是根据他们在研究生院的第一年和他们选择的论文实验室对该计划表达的兴趣自行选择的。该计划的学生必须将他们的课程工作集中在遗传学和基因组学方面，包括要求参加生物数据定量分析课程。我们的学生将在选择课程和轮换指导教师顾问谁是PGG的一部分。PGG学生还将参加一系列计划活动，包括（1）年度秋季研讨会，（2）每月会议，让他们谈论自己的研究，与高年级学生互动，并与博士后互动，包括那些研究临床遗传学的人，以及（3）每年邀请和主持两个外部研讨会演讲者的机会。学生将被监测为博士学位的进展。由他们的论文咨询委员会，其中将包括，除了论文顾问，至少一名PGG教师。此外，学生将撰写摘要，并通过海报或在我们的年度研讨会上演讲来展示他们的作品。总的来说，这个培训计划应该为我们的学生提供出色的培训，使他们成为遗传学和基因组学领域的高产独立调查人员。 公共卫生相关性：许多人类疾病，包括糖尿病、癌症和心脏病，都是由遗传因素引起的，这些遗传因素会从一代遗传到下一代。然而，我们对遗传学如何导致大多数疾病的理解很差，需要进一步研究。我们的研究培训计划将教授博士学位。学生在遗传学的最现代的领域，使他们能够运用他们的知识，以促进我们在人类生物学和疾病领域的理解。

DESCRIPTION (provided by applicant): This is a new application to support 12 graduate students in their second year of a Ph.D. Program in Genetics and Genomics (PGG) at Harvard Medical School. The goal of this program is to provide our students with comprehensive and rigorous training in genetics, including quantitative analysis of genetic and genomic data. This training comes from coursework, program activities, and dissertation research. The students have the opportunity to carry out Ph.D. research in one of several laboratories, centered around, but not exclusive to, the Department of Genetics. The laboratories of training grant faculty cover a wide range of research areas, ranging from prokaryotic gene regulation to human biology and disease. Students supported by the training grant are part of the Biological and Biomedical Sciences (BBS) program, a large umbrella program that includes six departments. However, PGG students participate in a program that is distinct from the rest of BBS students in its focus on genetics and genomics. PGG students are self-selected for the program based on their expressed interest in the program during their first year of graduate school and their choice of dissertation laboratory. Students in the program are required to concentrate their course work in genetics and genomics, including a requirement to take a course in the quantitative analysis of biological data. Our students will be guided in choosing courses and rotations by faculty advisors who are part of the PGG. PGG students will also participate in a set of programmatic activities, including (1) an annual fall symposium, (2) monthly meetings that will allow them to talk about their own research, to interact with senior students, and to interact with postdocs, including those studying clinical genetics, and (3) the opportunity to invite and host two outside seminar speakers each year. Students will be monitored for progress towards a Ph.D. by their dissertation advisory committees, which will include, in addition to the dissertation advisor, at least one PGG faculty member. Furthermore, students will write abstracts and present their work by either a poster or a talk at our annual symposium. Taken together, this training plan should provide outstanding training for our students to become highly productive independent investigators in the areas of genetics and genomics. PUBLIC HEALTH RELEVANCE: Many human diseases, including diabetes, cancer, and heart disease are caused by genetic factors that are inherited from one generation to the next. However, our understanding of how genetics contributes to most diseases is poor and requires further research. Our research training program will teach Ph.D. students in the most modern areas of genetics so that they can apply their knowledge to advance our understanding in the areas of human biology and disease.