2010-2011 Enzymes, Coenzymes & Metabolic Pathways Gordon Research Conference

描述（由申请人提供）：本提案是为2010年和2011年“酶、辅酶和代谢途径”戈登研究会议提供部分支持，该会议定于2009年7月18日至23日和2010年7月10日至15日在新罕布什尔州沃特维尔谷的沃特维尔谷度假村举行。本次会议的长远目标是促进对生物化学途径及其相关催化剂的分子水平的理解。我们的具体目标是提供一个约36人的演讲计划（从海报摘要中选择6人），介绍RNA和核苷酸的最新进展，途径的调节和进化，黄酮酶，药物发现中的酶，同位素效应，生物氧化，动力学和动力学中的酶机制。下午的海报会议为所有与会者提供了一个展示他们工作的场所，并为初级调查员提供了一个与现场高级调查员互动的机会。这一提议的意义在于，酶GRC作为研究人员研究生化反应分子机制的试金石。这种应用与健康的关系源于这样一个事实，即疾病过程的分子描述对于化疗的设计是不可或缺的。

DESCRIPTION (provided by applicant): This proposal is for partial support of the 2010 and 2011 Gordon Research Conferences on "Enzymes, Coenzymes, and Metabolic Pathways", which are scheduled for 18 - 23 July 2009 and 10 - 15 July 2010 at Waterville Valley Resort, Waterville Valley, New Hampshire. The broad and long-term goal of this conference is to foster a molecular- level understanding of biochemical pathways and their associated catalysts. Our specific aim is to present a program of ~36 speakers (6 chosen from poster abstracts), describing recent advances in RNA and Nucleotides, Regulation and Evolution of Pathways, Flavoenzymes, Enzymes in Drug Discovery, Isotope Effects, Biological Oxidations, Dynamics, and Enzyme Mechanisms from Kinetics. Afternoon poster sessions provide a venue for all attendees to present their work and present an opportunity for junior investigators to interact with senior investigators in the field. The significance of this proposal is that the Enzymes GRC serves as the touchstone for the community of researchers investigating the molecular mechanisms of biochemical reactions. The health-relatedness of this application derives from the fact that a molecular description of disease processes is indispensable for the design of chemotherapy. PUBLIC HEALTH RELEVANCE: Vast networks of intricately regulated biochemical pathways underlie all of biology. Discussions at this meeting cover a broad range of pathway-related topics that are important for the development of new therapies for human disease and treatments for human infections.