2010-2011 Enzymes, Coenzymes & Metabolic Pathways Gordon Research Conference

描述(由申请人提供)：本提案是为了部分支持2010年和2011年戈登研究会议的“酶、辅酶和代谢途径”，会议定于2009年7月18-23日和2010年7月10-15日在新罕布夏州沃特维尔山谷度假村举行。这次会议的广泛和长期目标是促进对生化途径及其相关催化剂的分子水平的理解。我们的具体目标是介绍一个有大约36名演讲者(6人选自海报摘要)的节目，描述RNA和核苷酸、途径的调节和进化、黄素酶、药物发现中的酶、同位素效应、生物氧化、动力学和动力学以及动力学中的酶机制的最新进展。下午的海报会议为所有与会者提供了介绍其工作的场所，并为初级调查员提供了与外地高级调查员互动的机会。这一建议的意义在于，GRC酶是研究生化反应分子机制的研究人员的试金石。这一应用的健康相关性源于这样一个事实，即疾病过程的分子描述对于化疗的设计是不可或缺的。 与公共健康相关：复杂调控的生化途径组成的庞大网络构成了所有生物学的基础。这次会议的讨论涵盖了广泛的与途径相关的主题，这些主题对于开发人类疾病的新疗法和人类感染的治疗方法非常重要。

DESCRIPTION (provided by applicant): This proposal is for partial support of the 2010 and 2011 Gordon Research Conferences on "Enzymes, Coenzymes, and Metabolic Pathways", which are scheduled for 18 - 23 July 2009 and 10 - 15 July 2010 at Waterville Valley Resort, Waterville Valley, New Hampshire. The broad and long-term goal of this conference is to foster a molecular- level understanding of biochemical pathways and their associated catalysts. Our specific aim is to present a program of ~36 speakers (6 chosen from poster abstracts), describing recent advances in RNA and Nucleotides, Regulation and Evolution of Pathways, Flavoenzymes, Enzymes in Drug Discovery, Isotope Effects, Biological Oxidations, Dynamics, and Enzyme Mechanisms from Kinetics. Afternoon poster sessions provide a venue for all attendees to present their work and present an opportunity for junior investigators to interact with senior investigators in the field. The significance of this proposal is that the Enzymes GRC serves as the touchstone for the community of researchers investigating the molecular mechanisms of biochemical reactions. The health-relatedness of this application derives from the fact that a molecular description of disease processes is indispensable for the design of chemotherapy. PUBLIC HEALTH RELEVANCE: Vast networks of intricately regulated biochemical pathways underlie all of biology. Discussions at this meeting cover a broad range of pathway-related topics that are important for the development of new therapies for human disease and treatments for human infections.