2010-2011 Enzymes, Coenzymes & Metabolic Pathways Gordon Research Conference

2010-2011 酶、辅酶

• 批准号: 7903557
• 负责人: BRUCE A PALFEY
• 金额: $ 0.5万
• 依托单位: GORDON RESEARCH CONFERENCES
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-05-01 至 2012-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7903557
• 关键词: Biochemical Pathway; Biochemical Reaction; Biological; Biology; Communities; Development; Disease; Enzymes; Enzymes and Coenzymes; Evolution; Fostering; Goals; Human; Infection; Isotopes; Kinetics; Metabolic Pathway; Molecular; New Hampshire; Nucleotides; Pathway interactions; Process; RNA; Regulation; Research; Research Personnel; Resort; Schedule; Work; abstracting; catalyst; chemotherapy; design; drug discovery; enzyme mechanism; human disease; meetings; oxidation; posters; programs; public health relevance; symposium

DESCRIPTION (provided by applicant): This proposal is for partial support of the 2010 and 2011 Gordon Research Conferences on "Enzymes, Coenzymes, and Metabolic Pathways", which are scheduled for 18 - 23 July 2009 and 10 - 15 July 2010 at Waterville Valley Resort, Waterville Valley, New Hampshire. The broad and long-term goal of this conference is to foster a molecular- level understanding of biochemical pathways and their associated catalysts. Our specific aim is to present a program of ~36 speakers (6 chosen from poster abstracts), describing recent advances in RNA and Nucleotides, Regulation and Evolution of Pathways, Flavoenzymes, Enzymes in Drug Discovery, Isotope Effects, Biological Oxidations, Dynamics, and Enzyme Mechanisms from Kinetics. Afternoon poster sessions provide a venue for all attendees to present their work and present an opportunity for junior investigators to interact with senior investigators in the field. The significance of this proposal is that the Enzymes GRC serves as the touchstone for the community of researchers investigating the molecular mechanisms of biochemical reactions. The health-relatedness of this application derives from the fact that a molecular description of disease processes is indispensable for the design of chemotherapy. PUBLIC HEALTH RELEVANCE: Vast networks of intricately regulated biochemical pathways underlie all of biology. Discussions at this meeting cover a broad range of pathway-related topics that are important for the development of new therapies for human disease and treatments for human infections.

描述（由申请人提供）：本提案旨在部分支持2010年和2011年戈登研究会议“酶、辅酶和代谢途径”，会议定于2009年7月18日至23日和2010年7月10日至15日在新罕布什尔州沃特维尔谷沃特维尔谷度假村举行。这次会议的广泛和长期目标是促进对生物化学途径及其相关催化剂的分子水平的理解。我们的具体目标是提出一个程序的~36扬声器（6从海报摘要中选择），描述在RNA和核苷酸，调节和进化的途径，黄素酶，酶在药物发现，同位素效应，生物氧化，动力学和酶机制动力学的最新进展。下午的海报展示会为所有与会者提供了一个展示其工作的场所，并为初级调查员提供了一个与外地高级调查员互动的机会。这一提议的意义在于，酶GRC作为研究生化反应分子机制的研究人员社区的试金石。这一应用的健康相关性源于这样一个事实，即疾病过程的分子描述对于化疗的设计是必不可少的。 公共卫生相关性：复杂调控的生物化学途径构成了整个生物学的基础。本次会议的讨论涵盖了广泛的途径相关主题，这些主题对于开发人类疾病的新疗法和人类感染的治疗非常重要。