FASEB 2010 Meeting On Nucleic Acid Enzymes

描述（由申请人提供）：FASEB 2010会议题为“核酸酶”，将重点讨论由DNA和RNA组成和/或作用于DNA和RNA的酶的结构、机制、生物学作用和医学相关性。这次会议吸引了来自结构生物学、生物化学和细胞生物学领域的跨学科科学家。本次会议将是由美国实验生物学学会联合会（FASEB）在该领域主办的第八届会议；最近一次是在2008年。会议提供了一个独特的论坛，讨论由核酸组成或作用于核酸的酶，DNA和RNA酶学在生物技术中的核心作用，以及与核酸酶有关的代谢紊乱和疾病。通过聚集结构生物学家、生化学家、化学家、细胞生物学家和临床医生这些通常互不交流的群体，可以培养新的兴趣、新的见解和跨学科的合作。科学计划将包括九个会议的口头报告，由杰出的特邀演讲者，青年教师和学生海报讨论以下主题领域：（1,2）磷酸二酯水解；(3)磷酰转移；（4,5）核酸加工与修饰；（6,7）电机、机械和易位；(8)聚合反应；(9)新兴方法、途径和领域。重要的是，我们将在整个会议上展示年轻的研究人员，而不是像过去那样在一次会议上；这样做是为了让这些调查人员能够充分接触到他们更资深的同事。组织者已经招募了主要的调查人员作为这些会议的讨论领导。该项目还将包括四次海报会议，从研究生、博士后和其他教职员工中选出优秀的海报进行简短的口头演讲。为了培养一种“新鲜”的方法和显著的智力更替和更新，大多数受邀演讲者都是会议的新成员，其中很大一部分是科学领域的初级教师和女性。FASEB 2010会议的目的是要有足够广泛定义的会议，以便来自不同领域的pi在一次会议中进行互动。我们认为，这是促进与会者之间进行新的思想交流的最佳途径。例如，在大多数情况下，DNA和RNA酶的生物学特性是完全不同的；然而，工具和方法是相似的，因此，由生物学定义的跨领域会议为思想交流提供了肥沃的土壤。会议的亲密形式将促进从事RNA和DNA酶不同方面工作的研究人员之间的信息和思想的自由交流，从而加快这两个领域的研究。

DESCRIPTION (provided by applicant): The FASEB 2010 meeting entitled "Nucleic Acid Enzymes" will focus on the structures, mechanisms, biological roles, and medical relevance of enzymes that are composed of, and/or act on DNA and RNA. The meeting attracts a broad cross-disciplinary group of scientists with expertise in structural biology, biochemistry, and cell biology. This meeting will be the 8th sponsored by the Federation of American Societies of Experimental Biology (FASEB) in this area; the most recent was in 2008. The meeting provides a unique forum for discussion of enzymes that are composed of or act on nucleic acids, the central role of DNA and RNA enzymology in biotechnology, and the metabolic disorders and diseases in which nucleic acid enzymes are implicated. By gathering structural biologists, biochemists, chemists, cell biologists and clinicians-groups that often do not speak to each other-new interests, new insights and interdisciplinary collaboration are fostered. The Scientific Program will consist of nine sessions of oral presentations by distinguished invited speakers, junior faculty, and student poster talks in the following subject areas: (1, 2) Phosphodiester hydrolysis; (3) Phosphoryl transfer; (4, 5) Nucleic acid processing and modification; (6, 7) Motors, Machines and Translocation; (8) Polymerization reactions; and (9) Emerging Methods, Approaches, and Areas. Importantly, we will feature young investigators throughout the meeting, rather than in a single session as in the past; this will be done so that these investigators can receive full exposure to their more senior colleagues. The organizers have recruited leading investigators to serve as discussion leaders for these sessions. The Program will also include four poster sessions, from which outstanding posters from graduate students, post-doc, and other faculty attendees will be selected for short oral presentations. To foster a 'fresh' approach and significant intellectual turnover and renewal, the majority of invited speakers are new to the meeting, and a significant percentage are junior faculty and women in science. The FASEB 2010 meeting aims to have sessions that are broadly enough defined that PIs from different fields will interact in one session. We feel that this is the best means to catalyze fresh exchange of ideas among the attendees. For example, in most cases the biology of DNA and RNA enzymes are quite distinct; however, the tools and approaches are similar and therefore sessions that cross areas defined by the biology provide fertile ground for exchange of ideas. The intimate format of the conference will promote free exchange of information and ideas among researchers working on diverse aspects of RNA and DNA enzymes, thereby expediting research in both fields. PUBLIC HEALTH RELEVANCE: Enzymes that act on nucleic acids are indispensable components of basic research and biotechnology; they are also taking on prominent roles in medicine as the analysis and manipulation of DNA and RNA from patients is integrated into the diagnosis, prognostic stratification, and choice of therapy in human disease states, especially cancers. Aberrations of nucleic acid enzymology that result in the loss of fidelity in replication, repair, and transcription are linked directly to human carcinogenesis. RNA plays a central role in human disease through small RNAs, transcription, and translation fidelity and regulation.