FASEB 2010 Meeting On Nucleic Acid Enzymes

描述(由申请者提供)：2010年FASEB会议题为“核酸酶”，将重点讨论由DNA和RNA组成和/或作用于DNA和RNA的酶的结构、机制、生物学作用和医学意义。这次会议吸引了具有结构生物学、生物化学和细胞生物学专业知识的广泛的跨学科科学家小组。这次会议将是美国实验生物学学会联合会(FASEB)在这一领域发起的第8次会议；最近一次是在2008年。会议提供了一个独特的论坛，讨论由核酸组成或作用于核酸的酶，DNA和RNA酶在生物技术中的核心作用，以及与核酸酶有关的代谢紊乱和疾病。通过聚集结构生物学家、生物化学家、化学家、细胞生物学家和临床医生--这些人往往彼此不说话--培养了新的兴趣、新的见解和跨学科合作。科学计划将包括以下主题领域的杰出特邀演讲者、初级教师和学生海报演讲的九次口头演讲：(1，2)磷酸二酯水解；(3)磷酸转移；(4，5)核酸加工和修饰；(6，7)电机、机器和易位；(8)聚合反应；以及(9)新兴方法、途径和领域。重要的是，我们将让年轻的调查人员参加整个会议，而不是像过去那样只参加一次会议；这样做是为了使这些调查人员能够充分接触到他们更资深的同事。组织者招募了主要的调查人员担任这些会议的讨论负责人。该计划还将包括四个海报会议，从中将挑选来自研究生、博士后和其他教职员工的优秀海报进行简短的口头陈述。为了培养一种“新鲜”的方法以及显著的知识更替和更新，大多数受邀的演讲者都是新来的，其中相当大一部分是科学领域的初级教员和女性。FASEB 2010会议的目标是举行足够广泛的会议，使来自不同领域的私人投资机构在一个会议上进行互动。我们认为，这是促进与会者进行新的思想交流的最好手段。例如，在大多数情况下，DNA酶和RNA酶的生物学是相当不同的；然而，工具和方法是相似的，因此跨越生物学定义的领域的会议为交流思想提供了肥沃的土壤。会议的亲密形式将促进致力于RNA和DNA酶不同方面的研究人员之间的信息和思想的自由交流，从而加快这两个领域的研究。 与公共卫生相关：作用于核酸的酶是基础研究和生物技术不可或缺的组成部分；它们在医学上也发挥着重要作用，因为对患者DNA和RNA的分析和操作被整合到人类疾病状态，特别是癌症的诊断、预后分层和治疗选择中。导致复制、修复和转录保真度丧失的核酸酶学异常直接与人类癌症的发生有关。RNA通过小RNA、转录和翻译的保真度和调节在人类疾病中发挥核心作用。

DESCRIPTION (provided by applicant): The FASEB 2010 meeting entitled "Nucleic Acid Enzymes" will focus on the structures, mechanisms, biological roles, and medical relevance of enzymes that are composed of, and/or act on DNA and RNA. The meeting attracts a broad cross-disciplinary group of scientists with expertise in structural biology, biochemistry, and cell biology. This meeting will be the 8th sponsored by the Federation of American Societies of Experimental Biology (FASEB) in this area; the most recent was in 2008. The meeting provides a unique forum for discussion of enzymes that are composed of or act on nucleic acids, the central role of DNA and RNA enzymology in biotechnology, and the metabolic disorders and diseases in which nucleic acid enzymes are implicated. By gathering structural biologists, biochemists, chemists, cell biologists and clinicians-groups that often do not speak to each other-new interests, new insights and interdisciplinary collaboration are fostered. The Scientific Program will consist of nine sessions of oral presentations by distinguished invited speakers, junior faculty, and student poster talks in the following subject areas: (1, 2) Phosphodiester hydrolysis; (3) Phosphoryl transfer; (4, 5) Nucleic acid processing and modification; (6, 7) Motors, Machines and Translocation; (8) Polymerization reactions; and (9) Emerging Methods, Approaches, and Areas. Importantly, we will feature young investigators throughout the meeting, rather than in a single session as in the past; this will be done so that these investigators can receive full exposure to their more senior colleagues. The organizers have recruited leading investigators to serve as discussion leaders for these sessions. The Program will also include four poster sessions, from which outstanding posters from graduate students, post-doc, and other faculty attendees will be selected for short oral presentations. To foster a 'fresh' approach and significant intellectual turnover and renewal, the majority of invited speakers are new to the meeting, and a significant percentage are junior faculty and women in science. The FASEB 2010 meeting aims to have sessions that are broadly enough defined that PIs from different fields will interact in one session. We feel that this is the best means to catalyze fresh exchange of ideas among the attendees. For example, in most cases the biology of DNA and RNA enzymes are quite distinct; however, the tools and approaches are similar and therefore sessions that cross areas defined by the biology provide fertile ground for exchange of ideas. The intimate format of the conference will promote free exchange of information and ideas among researchers working on diverse aspects of RNA and DNA enzymes, thereby expediting research in both fields. PUBLIC HEALTH RELEVANCE: Enzymes that act on nucleic acids are indispensable components of basic research and biotechnology; they are also taking on prominent roles in medicine as the analysis and manipulation of DNA and RNA from patients is integrated into the diagnosis, prognostic stratification, and choice of therapy in human disease states, especially cancers. Aberrations of nucleic acid enzymology that result in the loss of fidelity in replication, repair, and transcription are linked directly to human carcinogenesis. RNA plays a central role in human disease through small RNAs, transcription, and translation fidelity and regulation.