2010 Cardiac Regulatory Mechanisms Gordon Research Conference

描述（由申请人提供）： 本申请旨在为将于2010年6月6日至11日在科尔比索耶学院（科尔比-索耶，新罕布什尔州）举行的“心脏调节机制”戈登研究会议（GRC）提供部分资金。25年来，该会议一直致力于将新的研究人员和已有的领导者聚集在一起，展示他们最新的未发表的发现，并进行有意义的科学和社会互动。GRC的特殊非正式性质在促进跨越学科和地理的讨论方面是独一无二的，并使新的个人和科学联系得以发展。因此，每年都有大量的科学家回到这个会议。参与者是从最有前途和生产力的科学家中挑选出来的，他们处于职业生涯的各个阶段，来自不同的学科。他们的债券是一个共同的兴趣，在正常和患病的心脏调节的主题，重点是钙调节机制。我们有一个很好的基础科学相关的正常心脏的电气和机械性能，心肌细胞信号的调节，并在这些过程中，导致心脏功能障碍的异常组合。转基因动物的增加使用和定义的心血管表型的发展已经使得心血管系统易于处理，因此对细胞信号传导领域具有广泛和不断扩大的兴趣。今年的会议特别关注信号通路，包括几个新的研究领域，包括线粒体Ca调节，ER信号转导的新机制，亚细胞区室，支架及其真实的时间成像，以及InsP 3在心脏中仍有争议的作用。其他会议集中在心律失常/起搏器功能，钙信号在心肌细胞和新的信号通路。讨论领导者负责并在历史上成功地促进了热烈的讨论和批判性的提问。事实上，本次会议的一个主要目标是营造一种包容、紧张、活跃和互动的气氛，突出争议，并通过加深对未决问题的理解来启发与会者。这是心血管科学的一个激动人心的时刻，因为转基因和基因敲除小鼠模型的使用，遗传信息和新技术使我们能够探索正常心脏功能的细胞和分子基础。我们正开始将这些新发现转化为对疾病机制、诊断、预防和治疗的更好理解。我们希望拟议的演讲既令人兴奋又及时，并通过从海报贡献和最近的出版物中招募演讲者，在口头会议中包括最新突破的科学和年轻的研究人员。这是一个经常参加的会议，新的与会者和年轻的科学家认为这是一个宝贵的学习和职业经验。公共卫生相关性：科学的重要进步取决于最新思想和新发现的公开交流。心脏调节机制的戈登研究会议（GRC）促成并催化了这种交流。会议的健康相关性在研究报告的性质中显而易见，这些研究报告侧重于了解正常心脏功能如何调节以及如何在疾病中失调。这些问题的解决，正如会谈和讨论所推进的那样，将指导未来的研究，并最终导致治疗心脏病的新治疗策略的发展。

DESCRIPTION (provided by applicant): This application seeks partial funding for the Gordon Research Conference (GRC) on "Cardiac Regulatory Mechanisms" to be held at Colby Sawyer College (Colby-Sawyer, NH) on June 6-11, 2010. For more than 25 years this conference has prided itself on bringing together new investigators and established leaders to present their latest unpublished findings and engage in meaningful scientific and social interactions. The special informal nature of the GRC is unique in fostering discussions that span disciplines and geography and enables new personal and scientific connections to develop. Accordingly an extraordinarily high number of scientists return to this conference year after year. Participants are chosen from amongst the most promising and productive scientists, at all stages in their careers and from diverse disciplines. Their bond is a common interest in the topic of regulation of the normal and diseased heart with a focus on Ca regulatory mechanisms. We have a good mix of fundamental science related to regulation of normal cardiac electrical and mechanical properties, cardiac myocyte cell signaling, and abnormalities in these processes that contribute to cardiac dysfunction. The increased use of genetically modified animals and the development of defined cardiovascular phenotypes has made the cardiovascular system tractable and thus of broad and expanding interest to the cell signaling field. This year's conference has a particular focus on signaling pathways and includes several new areas of intense research interest including mitochondrial Ca regulation, novel mechanisms of ER signal transduction, subcellular compartments, scaffolds and their real time imaging, and the still controversial role of InsP3 in the heart. Other sessions focus on arrhythmias/pacemaker function, Ca signaling in myocytes and novel signaling pathways. Discussion leaders are charged with and are historically successful at promoting lively discussions and critical questioning. Indeed a key objective of this conference is to foster an inclusive, intense, lively and interactive atmosphere that highlights controversies and enlightens participants by providing a deeper understanding of unresolved issues. This is an exciting time in cardiovascular science because of the use of transgenic and knockout mouse models, genetic information and new technologies that allow us to explore the cellular and molecular bases of normal cardiac function. We are beginning to translate these new findings into a better understanding of disease mechanisms, diagnosis, prevention and treatment. We expect the proposed presentations to be both exciting and timely, and to include late breaking science and young investigators in the oral session by recruiting speakers from poster contributions and recent publications. This is a conference that those who have regularly attended look forward to, and that new attendees and young scientists recognize as an invaluable learning and career experience. PUBLIC HEALTH RELEVANCE: Important advances in science depend on the open exchange of the latest ideas and new findings. The Gordon Research Conference (GRC) on Cardiac Regulatory Mechanisms enables and catalyzes such exchange. The health relatedness of the conference is evident in the nature of the research presentations which focus on understanding how normal cardiac function is regulated and how it becomes dysregulated in disease. Resolution of these issues, as advanced by the talks and discussion, will direct future research and ultimately lead to the development of new therapeutic strategies to treat heart disease.