2010 Cardiac Regulatory Mechanisms Gordon Research Conference

2010年心脏调节机制戈登研究会议

• 批准号: 7905509
• 负责人: JOAN HELLER BROWN
• 金额: $ 1万
• 依托单位: GORDON RESEARCH CONFERENCES
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-05-01 至 2011-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7905509
• 关键词: Area; Arrhythmia; Cardiac; Cardiac Myocytes; Cardiovascular system; Charge; Development; Diagnosis; Discipline; Disease; Fostering; Functional disorder; Funding; Future; Genetic; Genetically Modified Animals; Geography; Health; Heart; Heart Diseases; Image; Knockout Mice; Lead; Learning; Mechanics; Mitochondria; Molecular; Muscle Cells; Nature; Oral; Pacemakers; Participant; Phenotype; Prevention; Process; Property; Publications; Recruitment Activity; Regulation; Research; Research Personnel; Resolution; Role; Science; Scientist; Signal Pathway; Signal Transduction; Social Interaction; Staging; Time; Transgenic Organisms; Translating; base; career; college; experience; interest; mouse model; new technology; novel; novel therapeutics; planetary Atmosphere; posters; public health relevance; scaffold; symposium

DESCRIPTION (provided by applicant): This application seeks partial funding for the Gordon Research Conference (GRC) on "Cardiac Regulatory Mechanisms" to be held at Colby Sawyer College (Colby-Sawyer, NH) on June 6-11, 2010. For more than 25 years this conference has prided itself on bringing together new investigators and established leaders to present their latest unpublished findings and engage in meaningful scientific and social interactions. The special informal nature of the GRC is unique in fostering discussions that span disciplines and geography and enables new personal and scientific connections to develop. Accordingly an extraordinarily high number of scientists return to this conference year after year. Participants are chosen from amongst the most promising and productive scientists, at all stages in their careers and from diverse disciplines. Their bond is a common interest in the topic of regulation of the normal and diseased heart with a focus on Ca regulatory mechanisms. We have a good mix of fundamental science related to regulation of normal cardiac electrical and mechanical properties, cardiac myocyte cell signaling, and abnormalities in these processes that contribute to cardiac dysfunction. The increased use of genetically modified animals and the development of defined cardiovascular phenotypes has made the cardiovascular system tractable and thus of broad and expanding interest to the cell signaling field. This year's conference has a particular focus on signaling pathways and includes several new areas of intense research interest including mitochondrial Ca regulation, novel mechanisms of ER signal transduction, subcellular compartments, scaffolds and their real time imaging, and the still controversial role of InsP3 in the heart. Other sessions focus on arrhythmias/pacemaker function, Ca signaling in myocytes and novel signaling pathways. Discussion leaders are charged with and are historically successful at promoting lively discussions and critical questioning. Indeed a key objective of this conference is to foster an inclusive, intense, lively and interactive atmosphere that highlights controversies and enlightens participants by providing a deeper understanding of unresolved issues. This is an exciting time in cardiovascular science because of the use of transgenic and knockout mouse models, genetic information and new technologies that allow us to explore the cellular and molecular bases of normal cardiac function. We are beginning to translate these new findings into a better understanding of disease mechanisms, diagnosis, prevention and treatment. We expect the proposed presentations to be both exciting and timely, and to include late breaking science and young investigators in the oral session by recruiting speakers from poster contributions and recent publications. This is a conference that those who have regularly attended look forward to, and that new attendees and young scientists recognize as an invaluable learning and career experience. PUBLIC HEALTH RELEVANCE: Important advances in science depend on the open exchange of the latest ideas and new findings. The Gordon Research Conference (GRC) on Cardiac Regulatory Mechanisms enables and catalyzes such exchange. The health relatedness of the conference is evident in the nature of the research presentations which focus on understanding how normal cardiac function is regulated and how it becomes dysregulated in disease. Resolution of these issues, as advanced by the talks and discussion, will direct future research and ultimately lead to the development of new therapeutic strategies to treat heart disease.

描述(由申请人提供)： 本申请旨在为将于2010年6月6-11日在密歇根州科尔比索耶学院(Colby-Sawyer，NH)举行的戈登研究会议(GRC)提供部分资金。25年多来，这个会议一直以聚集新的研究人员和老牌领导人而自豪，他们展示了他们最新的未发表的发现，并参与了有意义的科学和社会互动。GRC的特殊非正式性质在促进跨越学科和地理的讨论方面是独一无二的，并使新的个人和科学联系得以发展。因此，每年都有非常多的科学家回到这个会议上。参与者是从最有前途和最多产的科学家中挑选出来的，他们的职业生涯各个阶段和不同的学科。他们的结合是对正常和疾病心脏调节这一话题的共同兴趣，重点是钙调节机制。我们有很好的基础科学，涉及正常心脏电和机械特性的调节，心肌细胞信号传递，以及这些过程中导致心脏功能障碍的异常。越来越多的转基因动物的使用和明确的心血管表型的发展使心血管系统变得易于管理，从而引起了细胞信号领域的广泛和广泛的兴趣。今年的会议特别关注信号通路，包括几个新的研究领域，包括线粒体钙调节，内质网信号转导的新机制，亚细胞室，支架及其实时成像，以及InsP3在心脏中的作用仍有争议。其他会议集中在心律失常/起搏器功能、心肌细胞内的钙信号和新的信号通路。讨论领导者肩负着推动生动讨论和批判性提问的历史重任，而且历来都是成功的。事实上，这次会议的一个关键目标是营造一种包容、紧张、活跃和互动的气氛，通过加深对悬而未决的问题的理解，突出争议并启发与会者。这是心血管科学中令人兴奋的时刻，因为转基因和基因敲除小鼠模型、遗传信息和新技术的使用，使我们能够探索正常心脏功能的细胞和分子基础。我们正开始将这些新发现转化为对疾病机制、诊断、预防和治疗的更好理解。我们希望拟议的演讲既令人兴奋又及时，并通过从海报稿件和最近的出版物中招募发言者，将最新的科学和年轻的研究人员包括在口头会议中。这是一次经常参加的人期待的会议，新与会者和年轻科学家认为这是一次宝贵的学习和职业经历。公共卫生相关性：科学的重大进步取决于最新思想和新发现的公开交流。关于心脏调节机制的戈登研究会议(GRC)使这种交流成为可能，并促进了这种交流。会议与健康的相关性从研究报告的性质中可见一斑，研究报告的重点是了解正常的心脏功能是如何调节的，以及它在疾病中是如何变得失调的。会谈和讨论提出的这些问题的解决将指导未来的研究，并最终导致开发治疗心脏病的新治疗策略。