International meeting on translational research for motor units

运动单位转化研究国际会议

• 批准号: 7917847
• 负责人: Charles Heckman
• 金额: $ 1.6万
• 依托单位: NORTHWESTERN UNIVERSITY AT CHICAGO
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-04-01 至 2011-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7917847
• 关键词: Action Potentials; Animals; Cells; Disease; Europe; Goals; Human; International; Measures; Motor; Motor Neurons; Muscle Fibers; Neurons; Output; Paris, France; Pattern; Postdoctoral Fellow; Preparation; Research Personnel; Sensory; Series; Spinal; Students; System; Translational Research; Travel; United States; Universities; Work; human subject; insight; meetings; public health relevance

DESCRIPTION (provided by applicant): Spinal motoneurons provide the output for all motor commands and thus receive inputs from many different motor systems in the CNS, both supraspinal and sensory. Motoneurons connect directly to muscle fibers and motoneuron action potentials are one to one with their muscle fiber action potentials. Because muscle fiber action potentials are easy to assess in human subjects, motoneurons are the only neurons in the CNS whose firing patterns can be readily measured in human subjects. These motoneuron firing patterns have the potential to provide deep insights into function in CNS motor systems in humans, in both normal and disease states. Over that past 9 years, a series of international meetings on motoneurons have been implemented with the goal of bringing together researchers who study cellular mechanism of motoneuron firing patterns in animal preparations with researchers who study motoneuron firing patterns in human subjects. This proposal is for travel support for trainees (post-docs and students) to attend the 6th meeting in this series, entitled "Towards Translational Research in Motoneurons". These motoneuron meetings have alternated between the United States and Europe from their inception in 2000. The interactions at these meeting have been essential in a number of advances that now bring the field to the threshold of true translational work to develop new therapies. This is the primary focus of the meeting that will occur at Universit¿ Paris Descartes, Paris, France in the summer of 2010 (July 9-13). The meeting has become very popular and offers many opportunities for presentations and discussions for trainees. PUBLIC HEALTH RELEVANCE: Motoneurons are the only cells in the CNS whose firing pattern can be measured in human subjects. The 6th international meeting on motoneuron, which will take place in the summer of 2010 at the University of Paris, provides trainees with many opportunities for presentation and discussion motoneurons in normal and disease states. This proposal seeks travel support for this purpose.

描述(申请人提供)：脊髓运动神经元为所有运动指令提供输出，因此接受来自中枢神经系统中许多不同运动系统的输入，包括棘上和感觉。运动神经元直接与肌肉纤维相连，运动神经元动作电位与其肌肉纤维动作电位是一一对应的。由于肌肉纤维动作电位在受试者中很容易评估，运动神经元是中枢神经系统中唯一可以在受试者中容易测量到其放电模式的神经元。这些运动神经元的放电模式有可能为人类中枢神经系统运动系统的功能提供深入的见解，无论是在正常状态还是在疾病状态下。在过去的9年里，已经实施了一系列关于运动神经元的国际会议，目的是将研究动物准备中运动神经元放电模式的细胞机制的研究人员与研究人类受试者运动神经元放电模式的研究人员聚集在一起。这项提议是为了支持受训人员(博士后和学生)参加这一系列会议中的第六次会议，该会议题为“走向运动神经元的翻译研究”。自2000年成立以来，这些运动神经元会议一直在美国和欧洲之间交替举行。这些会议上的互动在一些进展中是必不可少的，这些进展现在将该领域带入了开发新疗法的真正转化工作的门槛。这是将于2010年夏天(7月9日至13日)在法国巴黎笛卡尔大学举行的会议的主要焦点。会议变得非常受欢迎，为学员提供了许多介绍和讨论的机会。 公共卫生相关性：运动神经元是中枢神经系统中唯一可以在受试者身上测量到其放电模式的细胞。将于2010年夏季在巴黎大学举行的第六届运动神经元国际会议为学员提供了许多机会介绍和讨论正常和疾病状态下的运动神经元。这项提议寻求为此目的提供旅行支持。