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Novel Translucent Nanocomposite Biomaterials

新型半透明纳米复合生物材料

基本信息

批准号：
7777906
负责人：
Judit E Puskas
金额：
$ 23.17万
依托单位：
UNIVERSITY OF AKRON
依托单位国家：
美国
项目类别：
财政年份：
2010
资助国家：
美国
起止时间：
2010-03-01 至 2013-02-28
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/7777906
关键词：
Address Adopted American Arts Back Benchmarking Binding Biocompatible Biocompatible Materials Breast Cancer Patient Carbon Carbon Black Cell Nucleus Cell Proliferation Collaborations Commit Communities Contracture Coronary Country Data Diagnosis Education Elastomers Engineering Excision Failure Fibrosis Filler Funding Future Gel Generations Goals Grant Group Meetings Health Health Services Research Health Status Health system Hematoma Hemorrhage Immersion Investigative Technique Implant In Vitro Incidence Infection Inflammatory Interdisciplinary Study Internal Breast Prosthesis Journals Learning Legal patent Malignant Neoplasms Mammaplasty Mastectomy Materials Testing Mechanics Medical Medical Device Mentors Methods Mind Modeling Molecular Weight Monitor Montmorillonite Necrosis Ohio Operative Surgical Procedures Optics Outcome Patients Peer Review Performance Pharmaceutical Preparations Polymers Postdoctoral Fellow Process Property Prosthesis Psychological reinforcement Publications Publishing Reaction Reporting Reproducibility Research Research Personnel Rupture Safety Saline Schedule School Teachers Science Scientist Shapes Silicone Elastomers Silicone Gels Societies Solutions Spinal Stents Structure Students Supervision Survival Rate Talents Technology Testing Training Trees United States National Institutes of Health Universities Woman Work Youth base biocompatible polymer biomaterial compatibility biomaterial development calcification career clay college copolymer design effective therapy elastomeric experience graduate student health science research high school improved in vivo isobutylene malignant breast neoplasm meetings melting member middle school nano nanocomposite nanoparticle next generation novel operation outreach outreach program particle programs public health relevance research study response skills styrofoam success symposium teacher vinyltoluene

项目摘要

DESCRIPTION (provided by applicant): This project aims to develop a new class of biocompatible nanocomposite using montmorillonite nano- clay with our proprietary polymer - an arborescent form of poly(isobutylene-b-(p-methylstyrene-co- isobutylene)) block copolymer (arbIB-MS), as an alternative to silicone rubber in a breast implant model. This model was selected because of the wide-spread breast cancer among American women, with one in eight women likely to develop invasive breast cancer. The existing design and material choice of silicone rubber for breast implants are associated with health complications, such as gel bleed and capsular contracture, to require patients to undergo re-operations for correction or implant removal. This situation calls for new materials. Our preliminary results show that the carbon nanocomposite of arbIB-MS mechanical performance and biocompatibility exceeds that of silicone rubber. Blending nano-clay into this polymer can further enhance the overall material performance and retain optical transparency/translucency. In this two-year project, specific aims are set to synthesize arbIB-MS at a lab-batch scale, prepare arbIB-MS-clay nanocomposites, evaluate important properties, such as thermal, physical and mechanical properties, and establish the in vitro biocompatibility of these materials (in collaboration with SUMMA Health System). The research tasks of the project have been designed to train and engage a team of a post-doctoral fellow, a graduate student, an undergraduate student, a local high school teacher with a high school student in biomedical and material science research, under the supervision of Dr. Puskas and our collaborators at SUMMA. The undergraduate students and the high school teacher are involved as an outreach initiative to encourage an early immersion of talented youths in scientific study, and bring "research into our classroom" at the local high school level to instill a positive perspective of science, technology and engineering in the next generations of potential graduate students. The project will be tied in with existing and successful outreach programs such as Polymer in a Backpack, Upward Bound and Educational Talent Search, designed for middle school students. The post- doctoral fellow and graduate student will be challenged to develop and conduct research related to biomedicine. Through informal discussion, regular group meetings, regional or national scientific meetings of the Society for Biomaterials, and journal publications, the team members trained in traditional polymer and material science will be given opportunities to present research findings to the biomedical community. If funded, the proposed project would be the first NIH-funded research in the Department of Polymer Science, the leading polymer program in the nation and widely recognized globally. PUBLIC HEALTH RELEVANCE: This AREA project is to develop novel translucent elastomeric clay nanocomposites and test their biocompatibility in vitro. The College of Polymer Science and Polymer Engineering at the University of Akron is the largest polymer research program in the country, offering unique expertise in biomaterial development. This AREA grant would be the first NIH grant in the Department of Polymer Science, exposing teachers and students to health-related research.

描述(申请人提供)：这个项目旨在开发一种新型的生物相容性纳米复合材料，使用蒙脱土纳米粘土与我们的专利聚合物-树枝状的聚(异丁烯-b-(对甲基苯乙烯-异丁烯)共聚物(ARBIB-MS))，作为乳房植入物模型中硅橡胶的替代品。之所以选择这种模式，是因为美国女性中广泛传播的乳腺癌，每八名女性中就有一人可能患上浸润性乳腺癌。现有的硅橡胶乳房植入物的设计和材料选择与健康并发症有关，如凝胶出血和包膜紧缩，需要患者再次手术进行矫正或取出假体。这种情况需要新的材料。初步研究结果表明，ARBIB-MS碳纳米复合材料的力学性能和生物相容性均优于硅橡胶。将纳米粘土掺入这种聚合物中，可以进一步提高材料的整体性能，并保持光学透明/半透明。在这个为期两年的项目中，明确的目标是在实验室批量合成Arbib-MS，制备Arbib-MS-Clay纳米复合材料，评估重要的性能，如热、物理和机械性能，并建立这些材料的体外生物兼容性(与Summa Health System合作)。该项目的研究任务旨在培养和聘用一支由博士后、研究生、本科生、当地高中教师和高中生组成的生物医学和材料科学研究团队，由普斯卡斯博士和我们在SUMMA的合作者监督。本科生和高中教师参与其中，作为一项外展倡议，鼓励有才华的年轻人尽早沉浸在科学学习中，并在当地高中层面将“研究带入我们的课堂”，向下一代潜在的研究生灌输积极的科学、技术和工程观点。该项目将与现有和成功的外展项目相结合，如为中学生设计的背包中的聚合物、向上绑定和教育人才搜索。博士后和研究生将面临开发和开展与生物医学相关的研究的挑战。通过非正式讨论、定期小组会议、生物材料学会的区域或国家科学会议以及期刊出版物，受过传统聚合物和材料科学培训的团队成员将有机会向生物医学界介绍研究成果。如果得到资助，这个拟议的项目将是美国国立卫生研究院资助的聚合物科学系的第一个研究。聚合物科学系是美国领先的聚合物项目，得到了全球的广泛认可。公共卫生意义：这一领域的项目是开发新型半透明弹性粘土纳米复合材料，并在体外测试它们的生物相容性。阿克伦大学聚合物科学和聚合物工程学院是该国最大的聚合物研究项目，提供生物材料开发方面的独特专业知识。这一领域的拨款将是美国国立卫生研究院聚合物科学系的第一笔拨款，让教师和学生接触到与健康相关的研究。