Building Consensus on Qualitative Chest CT-based Subphenotypes for COPD

描述(由申请人提供)： 这次会议的提议是，将举行一次独特的一次性会议，主题为“就COPD基于胸部CT的定性亚型建立共识”。会议将在弗吉尼亚州莱斯顿的新美国放射学院教育中心举行。这次会议将汇聚肺病学和放射学领域对慢性阻塞性肺病感兴趣的思想领袖和年轻研究人员。这些会议的每个参与者都将单独阅读140份胸部CT扫描，并对从正常到重度COPD(0-4级)的受试者进行评分。讲座和小组讨论将用来就COPD亚型的胸部CT扫描的可视或定性评分标准达成共识，包括肺气肿和呼吸道疾病的类型、范围和严重程度。这次会议的主要目标是：1)就如何直观地读取不同COPD亚型的胸部CT扫描并为其评分达成共识；2)为定义COPD亚型的CT标准撰写一份共识文件；3)对700例CT扫描进行分类和评分，这些扫描将被放置在一个公共数据库中，作为科学家和公司在该领域继续开发的资源和数据库。本次会议将由COPD基因项目和COPD基金会赞助，COPD基因项目将提供所需的所有CT扫描，COPD基金会为会议提供部分资金支持和后勤支持。会议将限制为59名与会者(ACR教育中心提供的CT工作站数量)。它最初将向对慢性阻塞性肺病领域感兴趣的NHLBI支持的研究人员开放，然后根据可用的空间向普通科学界开放。公共卫生相关性：这项建议是为了召开放射学和肺病学领导人会议/研讨会，就如何对胸部CT扫描进行视觉评分以识别临床上重要的不同类型的COPD达成共识。这次会议将在弗吉尼亚州莱斯顿的美国放射学院教育中心举行，将使用由COPD基因项目创建的COPD受试者的胸部CT扫描。就COPD的不同重要亚型达成共识是开发这种主要肺部疾病的新疗法和个性化药物的关键一步。

DESCRIPTION (provided by applicant): This conference proposal is for a unique one-time only conference to be held on the subject of "Building Consensus on Qualitative Chest CT-based Subphenotypes for COPD." The conference will be held at the new American College of Radiology Education Center in Reston, Virginia. The conference will bring together thought leaders and young investigators in the field of pulmonology and radiology who have an interest in COPD. Each of these conference participants will individually read and score 140 chest CT scans from subjects who range from normal to severe COPD (GOLD Stages 0-4). Lectures and group discussions will be used to build consensus on the criteria to visually or qualitatively score chest CT scans for COPD subtypes that include the type, extent and severity of both emphysema and airway disease. The primary goals of this conference are to: 1) build consensus on how to visually read and score chest CT scans for different subphenotypes of COPD, 2) write a consensus document for the CT criteria to define COPD subphenotypes and 3) categorize and score 700 CT scans that will be placed in a public database as a resource and database for scientists and companies working to continue development in this field. This conference will be sponsored by the COPD Gene project, which will provide all of the CT scans required, and by the COPD Foundation, which is providing partial financial support and logistic support for the conference. The conference will be limited to 59 participants (the number of CT work stations available at the ACR Education Center). It will be initially open to NHLBI-supported investigators with an interest in the field of COPD and then, based on space available, open to the general scientific community. PUBLIC HEALTH RELEVANCE: This proposal is for a conference/workshop of leaders in radiology and pulmonology to develop consensus on how to visually score chest CT scans to identify clinically important different types of COPD. This conference will be held at the American College of Radiology Education Center in Reston, Virginia, and will use chest CT scans from COPD subjects created by the COPD Gene Project. Creating a consensus for the different important subtypes of COPD is a critical step in developing new therapies and personalized medicine for this major lung disease.