Building Consensus on Qualitative Chest CT-based Subphenotypes for COPD

就慢性阻塞性肺病基于胸部 CT 的定性亚表型建立共识

• 批准号: 7915158
• 负责人: James D Crapo
• 金额: $ 2.5万
• 依托单位: NATIONAL JEWISH HEALTH
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-02-01 至 2011-01-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7915158
• 关键词: American College of Radiology; Chest; Chronic Obstructive Airway Disease; Communities; Consensus; Databases; Development; Disease; Education; Educational workshop; Financial Support; Foundations; Genes; Goals; Gold; Logistics; Lung diseases; Medicine; Normal Range; Participant; Pulmonary Emphysema; Pulmonology; Radiology Specialty; Reading; Research Personnel; Resources; Reston; Scientist; Severities; Staging; Time; Virginia; Work; Writing; X-Ray Computed Tomography; base; interest; lectures; public health relevance; symposium

DESCRIPTION (provided by applicant): This conference proposal is for a unique one-time only conference to be held on the subject of "Building Consensus on Qualitative Chest CT-based Subphenotypes for COPD." The conference will be held at the new American College of Radiology Education Center in Reston, Virginia. The conference will bring together thought leaders and young investigators in the field of pulmonology and radiology who have an interest in COPD. Each of these conference participants will individually read and score 140 chest CT scans from subjects who range from normal to severe COPD (GOLD Stages 0-4). Lectures and group discussions will be used to build consensus on the criteria to visually or qualitatively score chest CT scans for COPD subtypes that include the type, extent and severity of both emphysema and airway disease. The primary goals of this conference are to: 1) build consensus on how to visually read and score chest CT scans for different subphenotypes of COPD, 2) write a consensus document for the CT criteria to define COPD subphenotypes and 3) categorize and score 700 CT scans that will be placed in a public database as a resource and database for scientists and companies working to continue development in this field. This conference will be sponsored by the COPD Gene project, which will provide all of the CT scans required, and by the COPD Foundation, which is providing partial financial support and logistic support for the conference. The conference will be limited to 59 participants (the number of CT work stations available at the ACR Education Center). It will be initially open to NHLBI-supported investigators with an interest in the field of COPD and then, based on space available, open to the general scientific community. PUBLIC HEALTH RELEVANCE: This proposal is for a conference/workshop of leaders in radiology and pulmonology to develop consensus on how to visually score chest CT scans to identify clinically important different types of COPD. This conference will be held at the American College of Radiology Education Center in Reston, Virginia, and will use chest CT scans from COPD subjects created by the COPD Gene Project. Creating a consensus for the different important subtypes of COPD is a critical step in developing new therapies and personalized medicine for this major lung disease.

描述（由申请人提供）： 本次会议提案是一次独特的一次性会议，主题是“建立COPD基于定性胸部CT亚表型的共识”。“会议将在弗吉尼亚州雷斯顿新的美国放射学教育中心学院举行。会议将汇集肺部和放射学领域对COPD感兴趣的思想领袖和年轻研究人员。这些会议参与者中的每一个将单独阅读和评分140个胸部CT扫描，这些扫描来自范围从正常到重度COPD（GOLD阶段0-4）的受试者。将通过讲座和小组讨论，就COPD亚型胸部CT扫描的视觉或定性评分标准达成共识，包括肺气肿和气道疾病的类型、程度和严重程度。本次会议的主要目标是：1）就如何直观地阅读和评分COPD不同亚型的胸部CT扫描建立共识，2）为定义COPD亚型的CT标准编写共识文件，3）对700个CT扫描进行分类和评分，这些扫描将被放置在公共数据库中，作为科学家和公司在该领域继续发展的资源和数据库。本次会议将由COPD基因项目和COPD基金会赞助，前者将提供所需的所有CT扫描，后者将为会议提供部分财政支持和后勤支持。会议将限制为59名与会者（ACR教育中心提供的CT工作站数量）。它最初将向对COPD领域感兴趣的NHLBI支持的研究人员开放，然后根据可用空间向一般科学界开放。公共卫生关系：本提案旨在召开放射学和肺病学领导者会议/研讨会，就如何对胸部CT扫描进行视觉评分以识别临床上重要的不同类型COPD达成共识。本次会议将在弗吉尼亚州雷斯顿的美国放射学教育中心学院举行，并将使用COPD基因项目创建的COPD受试者的胸部CT扫描。为COPD的不同重要亚型建立共识是为这种主要肺部疾病开发新疗法和个性化药物的关键一步。

项目成果

Quantitative computed tomography in chronic obstructive pulmonary disease.

• DOI: 10.1097/rti.0b013e318298733c
• 发表时间: 2013-09
• 期刊: Journal of thoracic imaging
• 影响因子: 3.3
• 作者: Lynch DA;Al-Qaisi MA
• 通讯作者: Al-Qaisi MA

GOLD 2011 disease severity classification in COPDGene: a prospective cohort study.

• DOI: 10.1016/s2213-2600(12)70044-9
• 发表时间: 2013-03
• 期刊: LANCET RESPIRATORY MEDICINE
• 影响因子: 76.2
• 作者: Han, MeiLan K.;Muellerova, Hana;Curran-Everett, Douglas;Dransfield, Mark T.;Washko, George R.;Regan, Elizabeth A.;Bowler, Russell P.;Beaty, Terri H.;Hokanson, John E.;Lynch, David A.;Jones, Paul W.;Anzueto, Antonio;Martinez, Fernando J.;Crapo, James D.;Silverman, Edwin K.;Make, Barry J.
• 通讯作者: Make, Barry J.