Building Consensus on Qualitative Chest CT-based Subphenotypes for COPD

就慢性阻塞性肺病基于胸部 CT 的定性亚表型建立共识

• 批准号: 7915158
• 负责人: James D Crapo
• 金额: $ 2.5万
• 依托单位: NATIONAL JEWISH HEALTH
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-02-01 至 2011-01-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7915158
• 关键词: American College of Radiology; Chest; Chronic Obstructive Airway Disease; Communities; Consensus; Databases; Development; Disease; Education; Educational workshop; Financial Support; Foundations; Genes; Goals; Gold; Logistics; Lung diseases; Medicine; Normal Range; Participant; Pulmonary Emphysema; Pulmonology; Radiology Specialty; Reading; Research Personnel; Resources; Reston; Scientist; Severities; Staging; Time; Virginia; Work; Writing; X-Ray Computed Tomography; base; interest; lectures; public health relevance; symposium

DESCRIPTION (provided by applicant): This conference proposal is for a unique one-time only conference to be held on the subject of "Building Consensus on Qualitative Chest CT-based Subphenotypes for COPD." The conference will be held at the new American College of Radiology Education Center in Reston, Virginia. The conference will bring together thought leaders and young investigators in the field of pulmonology and radiology who have an interest in COPD. Each of these conference participants will individually read and score 140 chest CT scans from subjects who range from normal to severe COPD (GOLD Stages 0-4). Lectures and group discussions will be used to build consensus on the criteria to visually or qualitatively score chest CT scans for COPD subtypes that include the type, extent and severity of both emphysema and airway disease. The primary goals of this conference are to: 1) build consensus on how to visually read and score chest CT scans for different subphenotypes of COPD, 2) write a consensus document for the CT criteria to define COPD subphenotypes and 3) categorize and score 700 CT scans that will be placed in a public database as a resource and database for scientists and companies working to continue development in this field. This conference will be sponsored by the COPD Gene project, which will provide all of the CT scans required, and by the COPD Foundation, which is providing partial financial support and logistic support for the conference. The conference will be limited to 59 participants (the number of CT work stations available at the ACR Education Center). It will be initially open to NHLBI-supported investigators with an interest in the field of COPD and then, based on space available, open to the general scientific community. PUBLIC HEALTH RELEVANCE: This proposal is for a conference/workshop of leaders in radiology and pulmonology to develop consensus on how to visually score chest CT scans to identify clinically important different types of COPD. This conference will be held at the American College of Radiology Education Center in Reston, Virginia, and will use chest CT scans from COPD subjects created by the COPD Gene Project. Creating a consensus for the different important subtypes of COPD is a critical step in developing new therapies and personalized medicine for this major lung disease.

描述（由申请人提供）： 本次会议提案旨在举办一次独特的一次性会议，主题为“就慢性阻塞性肺病基于胸部 CT 的定性亚表型建立共识”。会议将在弗吉尼亚州雷斯顿新建的美国放射学院教育中心举行。此次会议将汇集肺病学和放射学领域对慢性阻塞性肺病感兴趣的思想领袖和年轻研究人员。这些会议的每位参与者将单独阅读 140 份胸部 CT 扫描并对其进行评分，这些扫描来自正常到严重 COPD（黄金阶段 0-4）的受试者。讲座和小组讨论将用于就 COPD 亚型的胸部 CT 扫描视觉或定性评分标准达成共识，其中包括肺气肿和气道疾病的类型、范围和严重程度。本次会议的主要目标是：1）就如何直观读取和评分不同 COPD 亚表型的胸部 CT 扫描达成共识，2）为定义 COPD 亚表型的 CT 标准撰写共识文件，3）对 700 个 CT 扫描进行分类和评分，这些图像将放入公共数据库中，作为致力于该领域继续发展的科学家和公司的资源和数据库。本次会议将由 COPD 基因项目和 COPD 基金会赞助，该项目将提供所需的所有 CT 扫描，COPD 基金会将为会议提供部分财务支持和后勤支持。会议仅限 59 名参加者（ACR 教育中心可用的 CT 工作站数量）。它最初将向 NHLBI 支持的对 COPD 领域感兴趣的研究人员开放，然后根据可用空间向一般科学界开放。公共健康相关性：本提案旨在召开放射学和肺病学领域领导者会议/研讨会，以就如何对胸部 CT 扫描进行视觉评分以识别临床上重要的不同类型的 COPD 达成共识。本次会议将在弗吉尼亚州雷斯顿的美国放射学院教育中心举行，并将使用由 COPD 基因项目创建的 COPD 受试者的胸部 CT 扫描。针对慢性阻塞性肺病的不同重要亚型达成共识是针对这种主要肺部疾病开发新疗法和个性化医疗的关键一步。

项目成果

Quantitative computed tomography in chronic obstructive pulmonary disease.

• DOI: 10.1097/rti.0b013e318298733c
• 发表时间: 2013-09
• 期刊: Journal of thoracic imaging
• 影响因子: 3.3
• 作者: Lynch DA;Al-Qaisi MA
• 通讯作者: Al-Qaisi MA

GOLD 2011 disease severity classification in COPDGene: a prospective cohort study.

• DOI: 10.1016/s2213-2600(12)70044-9
• 发表时间: 2013-03
• 期刊: LANCET RESPIRATORY MEDICINE
• 影响因子: 76.2
• 作者: Han, MeiLan K.;Muellerova, Hana;Curran-Everett, Douglas;Dransfield, Mark T.;Washko, George R.;Regan, Elizabeth A.;Bowler, Russell P.;Beaty, Terri H.;Hokanson, John E.;Lynch, David A.;Jones, Paul W.;Anzueto, Antonio;Martinez, Fernando J.;Crapo, James D.;Silverman, Edwin K.;Make, Barry J.
• 通讯作者: Make, Barry J.