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Southwest Brain Bank

西南脑库

基本信息

批准号：
7804556
负责人：
PETER M THOMPSON
金额：
$ 46.13万
依托单位：
UNIVERSITY OF TEXAS HLTH SCIENCE CENTER
依托单位国家：
美国
项目类别：
财政年份：
2009
资助国家：
美国
起止时间：
2009-05-01 至 2012-04-30
项目状态：
已结题

项目摘要

DESCRIPTION (provided by applicant): Bipolar disorder is a severe debilitating mental illness affecting over three and half million Americans. This illness crosses all gender and ethnic boundaries to cause extensive morbidly and mortality. With this tremendous burden on the patients, their family and society who are supporting them much research is underway to identify the pathology and pathophysiology. The biological research to date on bipolar disorder and the other major mental illness is tantalizing but vague. It has become clear, that to study this brain disorder, that animal models will not work and postmortem analysis is required. Additionally, with the current methodological advances such as mRNA expression analysis, which uses postmortem tissue the pace of discovery and demand for tissue is quickening. Unfortunately, the national collection effort is unable to supply enough tissue for all studies on bipolar illness. The NIMH recognizes this problem and has determined that increasing the collection is a research priority. This R-24 grant is to further develop the infrastructure of the Southwest Brain Bank into a national resource. The Southwest Brain Bank is a brain collection facility whose goal it is to collect and disseminate brain tissue from the severely mentally ill, especially bipolar illness. The brain bank received start up funding from Administrative Supplements for Human Postmortem Brain Research in Mental Illness NOT-MH-01-010. With this funding the brain bank was established in the department of Psychiatry at the University of Texas Health Science Center at San Antonio. The location on campus has several advantages. First, we are part of a very active Department of Psychiatry with access to both its academic strengths and to thousands of mentally ill patients. Second, the Medical Examiners office of Bexar County and the University Hospital, which are our major donation sites, are on campus. Because of these factors we have been successful in recruiting donations from the seriously mentally ill and normal controls. Funding for this grant will allow the Brain Bank to continue and expand its effort in becoming a national resource.

描述（由申请人提供）：双相情感障碍是一种严重的衰弱性精神疾病，影响超过350万美国人。这种疾病跨越所有性别和种族界限，造成广泛的发病率和死亡率。由于患者，他们的家庭和支持他们的社会的巨大负担，正在进行许多研究以确定病理学和病理生理学。到目前为止，关于双相情感障碍和其他主要精神疾病的生物学研究是诱人的，但却模糊不清。很明显，要研究这种大脑疾病，动物模型不起作用，需要进行死后分析。此外，随着当前方法学的进步，例如使用死后组织的mRNA表达分析，对组织的发现和需求的步伐正在加快。不幸的是，国家收集的努力是无法提供足够的组织对双相情感疾病的所有研究。NIMH认识到这个问题，并确定增加收集是研究的优先事项。这项R-24赠款将进一步发展西南脑库的基础设施，使其成为国家资源。西南脑库是一个大脑收集设施，其目标是收集和传播严重精神病患者的脑组织，特别是双相情感障碍患者。该脑库获得了精神疾病人类死后脑研究管理补充材料NOT-MH-01-010的启动资金。在这笔资金的资助下，位于圣安东尼奥的德克萨斯大学健康科学中心的精神病学系建立了大脑银行。校园的位置有几个优势。首先，我们是一个非常活跃的精神病学部门的一部分，可以利用其学术优势和成千上万的精神病患者。第二，贝克萨尔县和大学医院的体检办公室，这是我们的主要捐赠地点，在校园里。由于这些因素，我们成功地从严重精神病患者和正常对照组中招募了捐赠者。这笔赠款的资金将使脑库能够继续并扩大其成为国家资源的努力。