TREATMENT OF PANIC DISORDER--ETHNIC AND SEROTONIN DIFFERENCES

恐慌症的治疗——种族和血清素差异

• 批准号: 5222067
• 负责人: PETER M THOMPSON
• 金额: --
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/5222067
• 关键词: Hispanic Americans; clinical research; clinical trials; gender difference; human subject; human therapy evaluation; mental disorder chemotherapy; placebos; racial /ethnic difference; serotonin

The objective of this study is to determine if chronic antagonism of the 5HT3 receptor which have been implicated in modulating anxiety can successfully treat panic disorder. To achieve this objective we propose a pilot study that will enroll 50 subjects in a 8 week single-blind label trial of ondansetron with a 2 week placebo run in. This should determine if gender and ethnicity are independent variables associated with outcome of treatment.

本研究的目的是确定是否慢性拮抗的 与调节焦虑有关的5HT3受体可以 成功治疗恐慌症 为了实现这一目标，我们建议 一项初步研究，将在8周单盲标签中招募50例受试者 恩丹西酮与安慰剂的2周试验 这将决定 如果性别和种族是与结果相关的独立变量， 治疗。