Animal Models

动物模型

• 批准号: 8033309
• 负责人: ELLEN M. CARPENTER
• 金额: $ 14.85万
• 依托单位: UNIVERSITY OF CALIFORNIA LOS ANGELES
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-08-16 至 2015-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8033309
• 关键词: Animal Disease Models; Animal Model; Animals; Area; Behavior assessment; Behavioral; Biological; Biology; Breeding; Cells; Genetically Engineered Mouse; Genotype; Individual; Institution; Knock-in Mouse; Knock-out; Laboratories; Maintenance; Mental Retardation and Developmental Disabilities Research Centers; Mus; Nature; Rattus; Research; Research Personnel; Scientist; Services; Tissues; Transgenic Animals; Transgenic Organisms; animal breeding; gene function; operation

The use of genetically-engineered mice and rats (e.g. transgenic, knock-out, knock-in, conditional transgenic, etc.) as animal models has become widespread in almost all aspects of biology. In many of the projects carried out by scientists within the IDDRC, genetically-engineered mice or rats are being used as animal models to determine the function of genes, fundamental biological mechanisms of cell/tissue function, and/or to use as animal models of disease or behavioral abnormalities. These animals have either been generated here at UCLA or they have been imported from other institutions and used to establish local breeding colonies. With this large increase in the availability and use of transgenic animals, there is a concomitant need for core services to help individual scientists create, breed, import, genotype and evaluate mouse and rat lines. Many, if not most, of the scientists obtaining these mice have not had to deal with breeding and genotyping of such animals before. Nonetheless, they need to be able to take advantage of these animal models to extend their research effort into important new areas. For these reasons, we have set up Core services to educate investigators about and perform these activities. The nature of the services for investigators will vary in their degree of sophistication and Core involvement for each investigator will depend upon the needs of individual laboratories.

使用基因工程小鼠和大鼠（如转基因、敲除、敲入、有条件的）