FOCUS ISSUE ON HIV AND THE CARDIOMETABOLIC SYNDROME

关注艾滋病毒和心脏代谢综合征

• 批准号: 8168733
• 负责人: TODD CADE
• 金额: $ 1.23万
• 依托单位: WASHINGTON UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-03-10 至 2010-12-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8168733
• 关键词: Adult; Age; Aging; Anti-Retroviral Agents; Antineoplastic Agents; Area; Behavioral; Cardiovascular Diseases; Cause of Death; Centers for Disease Control and Prevention (U.S.); Cessation of life; Child; Chronic; Complex; Computer Retrieval of Information on Scientific Projects Database; Data; Diabetes Mellitus; Drug abuse; Epidemic; Funding; General Population; Genetic; Grant; HIV; HIV-2; Health Services Accessibility; Heart Diseases; Human; Infection; Institution; Journals; Life; Life Style; Low income; Lung diseases; Malignant Neoplasms; Metabolic; Minority; Obesity; Pharmacotherapy; Process; Research; Research Personnel; Resources; Risk; Risk Factors; Source; Stroke; Syndrome; Therapeutic; United States National Institutes of Health; Virus Diseases; Woman; men; multidisciplinary; socioeconomics; virus related cancer

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Infection with human immunodeficiency virus (HIV), use of highly active antiretroviral drug therapies (HAART), undesirable lifestyle/behavioral choices, genetic background, and other factors all contribute to adverse metabolic and morphometric changes in appreciable numbers of adults and children living with HIV. At least in the developed world, HIV/AIDS has transitioned from certain death to a chronic, manageable condition with the potential for long-term salubrious survival, due to therapeutic advances made over the past 10yrs. But many challenges remain, as outlined by the articles in this volume of the Journal of the CardioMetabolic Syndrome. With longer-term survival, will HIV-infected people succumb to the causes of death that are most common among aging humans in the industrialized world, especially components of the cardiometabolic syndrome (heart disease, stroke, lung disease, diabetes), but at an earlier age? Does HIV-infection and the accompanying chronic proinflammatory processes, impart increased risk for these most common causes of death? Are there HIV-specific risk factors for the cardiometabolic syndrome? Recent observational data indicate that deaths from cardiovascular disease, diabetes, non-HIV-related cancer, and drug abuse may be increasing among HIV-infected people (4-8). In addition, socioeconomic and demographic data from the CDC suggest that low-income, poorly educated, young minority men and women with poor access to health care constitute a disproportionate percentage of people newly infected with HIV (2, 3). Are these not the same groups in the general population that are at greater risk for developing diabetes, obesity, heart disease, and cancer? Likewise, the HIV epidemic is most serious in resource-limited areas of the world. As these regions become more developed and industrialized, we anticipate a "collision of epidemics"; HIV and the cardiometabolic syndrome, and recent analyses support this notion (1). The issues are complex and will require multidisciplinary teams and approaches to resolve.

该子项目是利用该技术的众多研究子项目之一 资源由 NIH/NCRR 资助的中心拨款提供。子项目和 研究者 (PI) 可能已从 NIH 的另一个来源获得主要资金， 因此可以在其他 CRISP 条目中表示。列出的机构是 对于中心来说，它不一定是研究者的机构。 人类免疫缺陷病毒（HIV）感染、高活性抗逆转录病毒药物疗法（HAART）的使用、不良生活方式/行为选择、遗传背景和其他因素都会导致大量艾滋病毒感染者的代谢和形态变化。 至少在发达国家，由于过去十年治疗方法的进步，艾滋病毒/艾滋病已经从必死无疑转变为一种慢性、可控制的疾病，并有可能长期健康生存。 但正如《心脏代谢综合征杂志》本卷中的文章所概述的那样，许多挑战仍然存在。 随着生存时间的延长，艾滋病毒感染者是否会死于工业化世界老年人中最常见的死因，尤其是心脏代谢综合征（心脏病、中风、肺病、糖尿病），但年龄较早？ HIV 感染和伴随的慢性促炎症过程是否会增加这些最常见死因的风险？心脏代谢综合征是否存在 HIV 特异性危险因素？最近的观察数据表明，艾滋病毒感染者中死于心血管疾病、糖尿病、非艾滋病毒相关癌症和药物滥用的人数可能正在增加 (4-8)。 此外，疾病预防控制中心的社会经济和人口数据表明，低收入、教育程度低、难以获得医疗保健的年轻少数族裔男女在新感染艾滋病毒的人中所占比例过高 (2, 3)。 这些人不正是普通人群中患糖尿病、肥胖症、心脏病和癌症的高风险人群吗？ 同样，艾滋病毒流行在世界上资源有限的地区最为严重。 随着这些地区变得更加发达和工业化，我们预计会出现“流行病碰撞”； HIV 和心脏代谢综合征以及最近的分析支持了这一观点 (1)。 这些问题很复杂，需要多学科团队和方法来解决。