Systems Biology and Connective Tissue Disorders

系统生物学和结缔组织疾病

• 批准号: 8063338
• 负责人: Harry C., III Dietz
• 金额: $ 4万
• 依托单位: JOHNS HOPKINS UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-09-06 至 2011-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8063338
• 关键词: Address; Area; Biochemical; Biological; Biology; Clinical; Complement; Computer Simulation; Connective Tissue; Connective Tissue Diseases; Development; Discipline; Disease; Drug Design; Environment; Etiology; Evaluation; Extracellular Matrix; Extracellular Matrix Proteins; Funding Opportunities; Future; Genetic; Interdisciplinary Study; Knowledge; Maps; Marfan Syndrome; Mission; Molecular; Muscle; National Institute of Arthritis and Musculoskeletal and Skin Diseases; Pathogenesis; Pathway Analysis; Research Infrastructure; Research Personnel; Scientist; Seminal; Signal Transduction; Skin; Structure; System; Systems Biology; Therapeutic; Tissue Differentiation; Transforming Growth Factor beta; base; bone; experience; extracellular; high throughput screening; meetings; mouse model; multidisciplinary; novel; novel therapeutics; protein structure function; small molecule; theories; tool

DESCRIPTION (provided by applicant): Recent studies of mouse models of Marfan syndrome (MFS) have shown that devising a successful treatment for such a congenital disease requires an integrated and unbiased understanding of the network of reciprocal interactions among extracellular, signaling and intracellular molecules. It follows that a systematic and multidisciplinary examination of a broad range of connective tissue disorders (CTDs) in the NIAMS mission area (skin, bone and muscle) should be fruitful in accelerating discoveries of treatment of these diseases. Computational systems biology is an emerging powerful strategy that, combined with traditional biochemical, cellular and genetic approaches, can reveal novel regulatory principles. The proposed this meeting is therefore to bring together basic, translational and clinical researchers in the areas of extracellular matrix biology, TGF-2 signaling, CTD and systems biology to: 1. Assess the current state of knowledge in the relevant fields for applying systems biology approach to delineate fundamental disease mechanisms of connective tissues. 2. Explore the advantage and limitations of combining computational modeling predictions with structure-based drug design and high-throughput screening of small molecules for targeting specific CTDs. 3. Identify needs in new technical infrastructures, support initiatives and funding opportunities (RFAs and PAs) that can facilitate interactions among basic and clinical scientists, promote interdisciplinary research and expedite translational applications. Such a meeting will be the first to be held that attempts to integrate the themes of CTD pathogenesis, TGF-2 basic biology, small-molecule therapeutics and systems biology. .

描述（由申请人提供）：最近对马凡氏综合征（MFS）小鼠模型的研究表明，设计这种先天性疾病的成功治疗方法需要对细胞外、信号传导和细胞内分子之间相互作用的网络进行综合和公正的理解。因此，在NIAMS使命领域（皮肤、骨骼和肌肉）对广泛的结缔组织疾病（CTDs）进行系统和多学科检查，应有助于加速发现这些疾病的治疗方法。计算系统生物学是一种新兴的强大策略，与传统的生物化学，细胞和遗传方法相结合，可以揭示新的调控原则。因此，建议本次会议将汇集细胞外基质生物学，TGF-2信号传导，CTD和系统生物学领域的基础，转化和临床研究人员：1。评估相关领域的知识现状，以应用系统生物学方法来描述结缔组织的基本疾病机制。2.探索将计算建模预测与基于结构的药物设计和靶向特定CTD的小分子高通量筛选相结合的优势和局限性。3.确定新技术基础设施的需求，支持倡议和资助机会（RFA和PA），以促进基础和临床科学家之间的互动，促进跨学科研究并加快转化应用。这样的会议将是第一次尝试将CTD发病机制，TGF-2基础生物学，小分子治疗学和系统生物学的主题整合在一起。.