Comparative Effectiveness Research & the Cochrane Eyes & Vision Group

描述（由申请人提供）：眼病导致的视力损害和失明是发病率的重要来源，降低了所有年龄段人们的生活质量，并对卫生保健资源造成了巨大负担。诊断视力障碍和实施视力保护治疗的眼科护理专业人员，依靠比较有效性研究的结果来做出明智的医疗保健决定。尽管迫切需要更好的信息，但在美国，很少有成熟的基础设施来进行眼睛和视力系统评价，只有一个，Cochrane协作组织的眼睛和视力小组。美国卫星研究中心（CEVG）是专门针对特定学科的、可持续的、提供教育并通过允许任何人贡献来促进合作的，只要研究是高质量的。CEVG@US。该网站自1997年以来一直在发表评论。确保重要的眼睛和视力系统审查主题被优先考虑、执行、传播并保持最新；它教育并建立了一支执行高质量系统审查的劳动力队伍；并为美国研究人员提供了一个论坛，在开发比较有效性研究方法方面发挥重要作用。基于CEVG之前的经验和成就，本提案的首要目标是成为美国眼科和视力比较有效性研究的协调中心，特别是Cochrane系统评价。这个角色相当于临床试验或临床研究网络的协调中心。具体而言，目标是：1)培养和建立一支可持续发展的视觉科学比较有效性研究队伍；2)确定需要证据的目标领域；3)准备并保持针对目标问题的最新系统评审；4)开展证据缺口识别方法研究；5)建立一个以研究为基础的、公开的视力试验登记册；6)在系统综述中进行方法学研究；7)传播我们的研究成果。拟议的研究由Cochrane协作的长期基础设施提供服务，并由一支训练有素的研究团队领导。

DESCRIPTION (provided by applicant): Eye diseases leading to visual impairment and blindness are an important source of morbidity, decrease the quality of life for people of all ages, and place a substantial burden on health care resources. Eye care professionals, who diagnose vision disorders and practice sight-saving treatments, rely on findings from comparative effectiveness research to make well-informed health care decisions. Despite the critical need for better information, there are few established infrastructures for performing eyes and vision systematic reviews in the US only one, the Cochrane Collaboration's Eyes and Vision Group. US Satellite (CEVG(gUS) is subject specific, sustainable, provides education and facilitates collaboration by allowing anyone to contribute, as long as the research is high quality. CEVG@US. which has been producing reviews since 1997. ensures important eyes and vision systematic review topics are prioritized, performed, disseminated, and kept up-to-date; it educates and builds a workforce that performs high quality systematic reviews; and provides a forum for US researchers to play an instrumental role in developing methods for comparative effectiveness research. Building on CEVG's previous experiences and achievements, the over-arching objective of this proposal is to serve as a coordinating center for comparative effectiveness research, and specifically Cochrane systematic reviews, in eyes and vision in the US. This role is comparable to that of a coordinating center for a clinical trial or clinical research network. Specifically, the aims are to 1) educate and build a sustainable vision science workforce in comparative effectiveness research; 2) identify targeted areas where evidence is needed; 3) prepare and keep up-to-date systematic reviews addressing targeted questions; 4) conduct research on methods to identify evidence gaps; 5) build a study-based, publicly available vision trials register; 6) conduct methodological research in systematic reviews; 7) disseminate the results of our research. The proposed research is served by the long standing infrastructure of the Cochrane Collaboration, and is led by a highly trained research team. RELEVANCE: By conducting and supporting comparative effectiveness research, training eyes and vision practitioners and researchers, disseminating health information, the outcome of the proposed work will have substantial impact on preventing or treating eye diseases and/or visual impairment, and improving the quality of life for people of all ages.