Preterm Birth in Nulliparous Women: An Understudied Population at Great Risk

未产妇早产：未充分研究的高危人群

• 批准号: 8013036
• 负责人: Deborah A Wing
• 金额: $ 24.6万
• 依托单位: UNIVERSITY OF CALIFORNIA-IRVINE
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-01-10 至 2012-12-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8013036
• 关键词: Acculturation; Adopted; Affect; African American; American; Appointment; Asian Americans; Asians; Awareness; Behavior; Behavioral; Belief; Bioinformatics; Biological; Bioterrorism; Birth; Birth Rate; California; Central America; Central American; Characteristics; Child health care; China; Clinic; Clinical; Clinical Pathology; Clinical Research; Clinical Trials; Collection; Commitment Durations; Communication; Communities; Community Outreach; Conceptions; Contracts; Costa Rica; Country; County; Cultural Backgrounds; Data; Data Analyses; Databases; Detection; Discipline of obstetrics; Disease; Doctor of Philosophy; Doppler velocimetry; Economics; El Salvador; Elements; Enrollment; Ensure; Environmental Risk Factor; Epidemiologic Studies; Epidemiology; Ethnic Origin; Ethnic group; Etiology; Evaluation; Exclusion; Faculty; Fellowship; Fetal Growth; First Births; First Pregnancy Trimester; Foundations; Frequencies; Functional disorder; Funding; Genetic; Genetic Determinism; Genetic Medicine; Genetic Risk; Genomics; Geographic Locations; Geography; Goals; Grant; Group Practice; Growth; Gynecology; Hawaiian population; Hispanics; Household; Housing; Immigrant; Individual; Industry; Institutes; Institution; Insurance Coverage; Intervention; Investigation; Laboratory Research; Latina; Latino; Lead; Leadership; Letters; Location; Los Angeles; Managed Care; Maternal Age; Medical center; Methods; Mexican; Mexico; Mission; Mitochondria; Mitochondrial DNA; Molecular; Morbidity - disease rate; National Children' s Study; National Institute of Child Health and Human Development; Native Americans; Nature; Neonatal; Neonatology; Nicaragua; Obesity; Oranges; Outcome; Pacific Island Americans; Participant; Patient Care; Patient Education; Patients; Perinatal; Perinatology; Personal Satisfaction; Pharmacy facility; Physicians; Population; Population Sizes; Pregnancy; Premature Birth; Prenatal care; Prevention; Principal Investigator; Process; Productivity; Protocols documentation; Publications; Qualifying; Race; Randomized; Recruitment Activity; Research; Research Design; Research Infrastructure; Research Institute; Research Personnel; Research Support; Risk; Sampling; Scheme; Screening procedure; Services; Site; Socioeconomic Status; Source; South America; Southeastern Asia; Study Subject; Surveys; System; Testing; Time; Training; Ultrasonography; United States; United States National Institutes of Health; Universities; Weight; Wing; Woman; Work; base; clinical care; cohort; demographics; experience; fetal medicine; gene environment interaction; genetic epidemiology; insight; intergenerational; intrapartum; meetings; member; mortality; novel; outreach program; parity; patient population; phase 1 study; pregnant; premature; professor; programs; prospective; quality assurance; racial and ethnic; social; statistics; working group

The University of California, Irvine (UCI) has the required elements to participate in the consortium to evaluate genetic and environmental risk factors for preterm birth in nulliparous women. Deborah Wing (PI) and the Pathik Wadhwa (co-l) have extensive experience in study design, subject recruitment, data analysis, and publications from several NIH-funded and industry-sponsored single- and multiple-site studies. Dr. Wing directs the UCI Department of Obstetrics and Gynecology, Division of Maternal-Fetal Medicine and oversees its fellowship and clinical research mission. Dr. Wadhwa, director of the UCI Behavioral Perinatology Research Program, examines the interface between biological and behavioral processes in pregnancy, directs an NIH program project on gene-environment interactions in pregnancy, and also has participated in large working groups to outline research needs for the genetic determinants of preterm birth. We propose recruitment of subjects from a richly diverse racial and ethnic mix from UCI and our affiliate at Long Beach Memorial Medical Center. Our clinical enterprise and patient population ("7000 deliveries/year) make us well-prepared to participate in this consortium. Most of our patients receive prenatal care in the first trimester. We can capitalize on the growing research infrastructure for the Orange County, California, Vanguard Center for the National Children's Study to aid in recruitment, and can bring to this new investigation the infrastructure of the National Standard for Normal Fetal Growth study. This includes pre-approved protocols for survey administration, physical and ultrasound exams, biosample collection, sonographer training, and quality assurance. We have multiple electronic databases in place for antepartum and intrapartum data. We have a dedicated team of research staff plus an oversight committee comprised of faculty members and our lead research coordinators who meet regularly. We recently recruited Dongbao Chen, PhD, to oversee our Perinatal Research Laboratory; his group can provide expertise relevant to this RFA. We have well-established collaborative ties with neonatology, genetics, perinatal pathology, clinical laboratory, and research pharmacies which can aid in successful completion of this investigation. Unique to UCI are its Center for Molecular and Mitochondrial Medicine and Genetics (MAMMAG), Genetic Epidemiology Research Institute (GERI), the Institute of Genomics and Bioinformatics (IGB), and the Pacific-Southwest Center for Emerging Diseases and Bioterrorism (PSW RCE), each of which lend particular strengths to the study of genetic and environmental determinants of preterm birth.

加州大学欧文分校(UCI)有必要参加该联盟，以评估未分娩妇女早产的遗传和环境风险因素。黛博拉·荣(PI)和帕西克·瓦德瓦(共同担任L)在研究设计、受试者招募、数据分析和出版方面拥有丰富的经验，这些研究来自美国国立卫生研究院资助和行业赞助的多个单站点和多站点研究。荣博士领导UCI妇产科和母胎医学部，并监督其团契和临床研究任务。Wadhwa博士是UCI行为围产期研究项目的负责人，他研究怀孕期间生物和行为过程之间的相互作用，指导NIH关于怀孕期间基因与环境相互作用的项目，还参与了大型工作组，概述早产遗传决定因素的研究需求。我们建议从UCI和我们在长滩纪念医疗中心的附属机构招募来自丰富多样的种族和民族混合的受试者。我们的临床企业和患者群体(“每年7000次分娩”)使我们为加入这个联盟做好了充分的准备。我们的大多数患者在怀孕的前三个月接受产前护理。我们可以利用加利福尼亚州奥兰治县先锋国家儿童研究中心不断发展的研究基础设施来帮助招募，并可以将国家正常胎儿发育研究标准的基础设施引入这项新的调查。这包括预先批准的调查管理、体检和超声波检查、生物样本收集、超声师培训和质量保证协议。我们有多个电子数据库，用于产前和分娩期间的数据。我们有一支敬业的研究人员团队，外加一个由教职员工和我们的首席研究协调员组成的监督委员会，他们定期开会。我们最近聘请了陈东宝博士来监督我们的围产期研究实验室；他的团队可以提供与此RFA相关的专业知识。我们与新生儿学、遗传学、围产期病理学、临床实验室和研究药房建立了良好的合作关系，这有助于成功完成这项研究。UCI的独特之处在于其分子和线粒体医学和遗传学中心(MAMMAG)、遗传流行病学研究所(GERI)、基因组学和生物信息学研究所(IGB)以及太平洋-西南新兴疾病和生物恐怖主义中心(PSW RCE)，每个中心都为研究早产的遗传和环境决定因素提供了独特的优势。