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Realistic Human Perception of Spatio-Temporal Thalamic Microstimulation

人类对时空丘脑微刺激的真实感知

基本信息

批准号：
8074436
负责人：
DENNIS Alan TURNER
金额：
$ 19.23万
依托单位：
DUKE UNIVERSITY
依托单位国家：
美国
项目类别：
财政年份：
2010
资助国家：
美国
起止时间：
2010-05-15 至 2013-04-30
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/8074436
关键词：
Acute Behavioral Brain Cell Nucleus Cicatrix Clinical Complex Data Detection Development Devices Disease Distant Electrodes Esthesia Event Exploratory/Developmental Grant FDA approved Face Feedback Hand Heating Human Human Characteristics Lead Location Maps Mechanics Microelectrodes Modality Motion Motor Movement Nerve Nervous system structure Operative Surgical Procedures Pain Paresthesia Patients Pattern Perception Peripheral Peripheral Nerves Physiologic pulse Process Prosthesis Protocols documentation Recording of previous events Research Safety Sensory Sensory Process Signal Transduction Site Skin Spinal Cord Stimulus Structure of subthalamic nucleus Tactile Testing Thalamic structure Time Touch sensation Training Tremor arm awake experience flexibility microstimulation millimeter millisecond operation pressure programs public health relevance relating to nervous system research study response restoration sensory prosthesis somatosensory spatiotemporal

项目摘要

DESCRIPTION (provided by applicant): It has proven difficult to recreate perceptually accurate and realistic touch and pressure sensation following thalamic stimulation in humans. Previous human experiments have used primarily single-site microstimulation with regular patterns of stimulation, which consistently results in a perception of tingling or paresthesias, and only occasionally a more natural sensation. We propose to perform multi-site microstimulation in human sensory thalamus during intra-operative experiments, while performing thalamic DBS surgery. During these experiments we will first test pairs of electrodes in a 16 or 32-channel Adtech microwire array and a Tucker- Davis acute, switching headstage. We have developed a switching unit to rapidly connect various pairs of electrodes for microstimulation. Using this switching unit connected to the headstage we can rapidly evaluate multiple pairs of electrodes for the evoked sensory response. These experiments are a natural extension of our large experience in recording with these microwire arrays from motor thalamus and subthalamic nucleus during a complex behavioral task (n = 52 patients). Then, we will next apply patterned microstimulation (10 - 50 5A) at dual or multiple microwire combinations in the sensory thalamus, to recreate the evoked actual mechanical skin input. Patterns will initially consist of a decelerating stimulus with an increasing interpulse interval (like an adapting primary sensory response), an accelerating stimulus with progressively shorter interpulse intervals, and a constant pulse sequence, with the same number of pulses applied over a 1 sec period. The patient's perception of the thalamic stimulation will then be critically assessed for these three patterns, while progressively altering the amplitude, the duration (from 100 to 1000 msec) and the location of the stimulation (to different pairs). These experiments will both help reveal the critical patterning of the natural evoked responses in sensory thalamus, as well as provide a potential substrate for insertion of realistic sensory inputs for development of a sensory prosthetic device. The R21 mechanism will be used to develop the programmed multisite microstimulation protocols and to assess the patient-derived concept of realistic perception, in direct comparison to a graded touch signal. Further tests will use a DBS macro-electrode, but with patterned microstimulation, to assess whether it is possible to extend the microwire data to a larger field. PUBLIC HEALTH RELEVANCE: This project will study how the brain processes sensation and the perception of sensation, in the human thalamus. This study will be important to understanding diseases where sensation is abnormally altered, such with nerve damage. This research may help to understand how an artificial sensory signal could be interpreted as a normal sensation, if the proper spatial and temporal pattern can be recreated. These results may lead to a sensory prosthesis to replace sensation where the nervous system has been damaged, for restoration of function.

描述(申请人提供)：事实证明，在人类丘脑刺激后，很难重现感知上准确和真实的触摸和压力感觉。以前的人类实验主要使用单一部位的微刺激和规则的刺激模式，这种刺激总是会产生刺痛或感觉异常的感觉，只是偶尔会有更自然的感觉。我们建议在进行丘脑DBS手术的同时，在术中实验期间对人类感觉丘脑进行多部位微刺激。在这些实验中，我们将首先测试16或32通道Adtech微线阵列中的电极对，以及Tucker-Davis锐化开关主台。我们开发了一种开关装置，可以快速连接各种电极对，用于微刺激。使用这个连接到前台的开关单元，我们可以快速评估多对电极的诱发感觉反应。这些实验是我们在复杂行为任务(n=52名患者)中使用这些来自运动丘脑和丘脑底核的微线阵列进行记录的大量经验的自然延伸。然后，我们将在感觉丘脑的两个或多个微线组合上应用图案化微刺激(10-50 5A)，以重现诱发的实际机械皮肤输入。模式最初将由脉间间隔增加的减速刺激(如适应性初级感官反应)、脉间间隔逐渐缩短的加速刺激和恒定的脉冲序列组成，在1秒周期内施加相同数量的脉冲。然后针对这三种模式对患者的丘脑刺激感觉进行严格的评估，同时逐步改变刺激的幅度、持续时间(从100毫秒到1000毫秒)和刺激的位置(到不同的对)。这些实验将有助于揭示感觉丘脑中自然诱发反应的关键模式，并为开发感觉假体设备提供潜在的基础，为插入真实的感觉输入提供基础。R21机制将被用来开发程序化的多部位微刺激方案，并直接与分级触摸信号进行比较，评估患者衍生的真实知觉概念。进一步的测试将使用DBS宏观电极，但带有图案化的微刺激，以评估是否有可能将微线数据扩展到更大的领域。与公共健康相关：这个项目将研究大脑如何处理感觉以及人类丘脑对感觉的感知。这项研究将对理解感觉异常改变的疾病，如神经损伤，具有重要意义。这项研究可能有助于理解，如果能够重建适当的空间和时间模式，人工感觉信号如何被解释为正常感觉。这些结果可能导致一种感觉假体，以取代神经系统受损的感觉，以恢复功能。