Regulation of Filamentous Growth in Yeast

白色念珠菌是人类最常见的真菌病原体之一。它可以 在芽殖酵母、假菌丝和菌丝之间进行可逆的形态发生转变 增长形式。其独特的能力，从酵母菌切换到菌丝生长，以应对各种 环境信号不仅是其致病性所固有的，而且还提供了一个很好的 范式来理解信号通路如何协调生长和发育。的 本研究的目的是了解菌丝信号通路是如何整合外部 信号与时间和空间线索，以产生线性菌丝丝。 有五个具体目标： (1)在对菌丝诱导条件的初始响应期间菌丝信号传导的激活。 (2)细胞周期对菌丝信号的调控。 (3)细胞极性对菌丝信号的调控。 (4)鉴定控制细胞极性的菌丝信号传导的靶标。 (5)顶端细胞特异性定位和线性细胞分裂。

Candida albicans is one of the most frequently isolated fungal pathogens of humans. It can undergo reversible morphogenetic transitions among budding yeast, pseudohyphal, and hyphal growth forms. Its unique ability to switch from yeast to hyphal growth in response to various environmental signals not only is inherent to its pathogenicity, but also provides an excellent paradigm to understand how signaling pathways coordinate growth and development. The objectives of this research are to understand how hyphal signaling pathways integrate external signals with temporal and spatial cues to generate linear hyphal filaments. There are five specific aims: (1) Activation of hyphal signaling during the initial response to hyphal inducing conditions. (2) Regulation of hyphal signaling by cell cycle. (3) Regulation of hyphal signaling by cell polarity. (4) Identification of targets of hyphal signaling that control cell polarity. (5) Apical cell-specific localization and linear cell division.