Genetic Analysis of Dendrite Maintenance in Drosophila Sensory Neurons
果蝇感觉神经元树突维持的遗传分析
基本信息
- 批准号:7998972
- 负责人:
- 金额:$ 24.89万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2010
- 资助国家:美国
- 起止时间:2010-05-21 至 2013-04-30
- 项目状态:已结题
- 来源:
- 关键词:AffectAfferent NeuronsAllelesAxonBiologicalCellsConfocal MicroscopyDefectDendritesDevelopmentDiseaseDown SyndromeDrosophila genusFoundationsFutureGene ExpressionGene Expression ProfilingGenesGeneticGenetic ScreeningLasersLifeLinkMaintenanceMediatingMental RetardationMicrosurgeryMolecularMonitorMutationNeurodegenerative DisordersNeuronsPathway interactionsPatientsPatternPhasePhosphotransferasesPolycombPost-Translational Protein ProcessingPropertyProteinsRegulationTimebasecell typedesigngene functiongenetic analysisinsightlaser capture microdissectionmutantnovelreceptive fieldresearch study
项目摘要
Dendrite arborization patterns are a hallmark of neuronal type and a critical determinant of neuronal function.
Although progress has been made in understanding how dendrites come to occupy their territory, very little is
known about how neurons maintain dendritic coverage of their receptive field. Since dendrite defects are the
strongest correlate with mental retardation, understanding the phenomenon of dendrite maintenance and its
underlying mechanisms has important implications for disease, particularly neurodegenerative disorders.
Nevertheless, technical limitations have made dendrite maintenance a largely intractable phenomenon. The
long-term objectives ofthis study are to define mechanisms that regulate dendrite maintenance in different
neuronal types. The general approach is to use genetic screening and microarray-based gene expression
profiling to identify genes that cell-autonomously regulate dendrite maintenance. Detailed genetic and cellbiological
analyses ofthe neuronal function of these genes should provide a basic understanding of mechanisms
regulating dendrite maintenance. The specific aims ofthis study are (1) to identify genes that are rquired for
dendrite maintenance and mutationally define different modes of dendrite maintenance in Drosophila sensory
neurons, (2] to characterize the molecular and cell-biological changes that occur as a neuron transitions from
establishing to maintaining receptive field coverage, and (3) to gain insight into how establishment and
maintenance of receptive field coverage are coordinated in a given neuron.
树突树突模式是神经元类型的标志,也是神经元功能的关键决定因素。
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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{{ truncateString('JAY Z PARRISH', 18)}}的其他基金
Identification of proteins that structurally couple epidermal cells to somatosensory neurons
表皮细胞与体感神经元结构耦合的蛋白质的鉴定
- 批准号:
10390199 - 财政年份:2021
- 资助金额:
$ 24.89万 - 项目类别:
Extrinsic signals required for maintenance of dendrite coverage
维持树突覆盖所需的外在信号
- 批准号:
8535230 - 财政年份:2011
- 资助金额:
$ 24.89万 - 项目类别:
Extrinsic signals required for maintenance of dendrite coverage
维持树突覆盖所需的外在信号
- 批准号:
8219746 - 财政年份:2011
- 资助金额:
$ 24.89万 - 项目类别:
Extrinsic signals required for maintenance of dendrite coverage
维持树突覆盖所需的外在信号
- 批准号:
8322031 - 财政年份:2011
- 资助金额:
$ 24.89万 - 项目类别:
Extrinsic signals required for maintenance of dendrite coverage
维持树突覆盖所需的外在信号
- 批准号:
9297382 - 财政年份:2011
- 资助金额:
$ 24.89万 - 项目类别:
Extrinsic signals required for maintenance of dendrite coverage
维持树突覆盖所需的外在信号
- 批准号:
8910794 - 财政年份:2011
- 资助金额:
$ 24.89万 - 项目类别:
Extrinsic signals required for maintenance of dendrite coverage
维持树突覆盖所需的外在信号
- 批准号:
8715870 - 财政年份:2011
- 资助金额:
$ 24.89万 - 项目类别:
Genetic Analysis of Dendrite Maintenance in Drosophila Sensory Neurons
果蝇感觉神经元树突维持的遗传分析
- 批准号:
8076747 - 财政年份:2010
- 资助金额:
$ 24.89万 - 项目类别:
Genetic Analysis of Dendrite Maintenance in Drosophila Sensory Neurons
果蝇感觉神经元树突维持的遗传分析
- 批准号:
8257545 - 财政年份:2010
- 资助金额:
$ 24.89万 - 项目类别:
Genetic Analysis of Dendrite Maintenance in Drosophila Sensory Neurons
果蝇感觉神经元树突维持的遗传分析
- 批准号:
7619266 - 财政年份:2008
- 资助金额:
$ 24.89万 - 项目类别:
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