2012 Thiol-based Redox Regulation & Signaling GRC and GRS

2012年硫醇基氧化还原调节

• 批准号: 8252744
• 负责人: LESLIE B POOLE
• 金额: $ 0.75万
• 依托单位: GORDON RESEARCH CONFERENCES
• 依托单位国家: 美国
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-09-22 至 2012-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8252744
• 关键词: Address; Aging; Amino Acids; Animal Model; Antioxidants; Apoptosis Regulation Gene; Area; Bioinformatics; Biological Models; Biology; Cell Cycle Regulation; Cell Proliferation; Cell physiology; Cells; Chemicals; Chemistry; Clinical; Collaborations; Communities; Complex; Cysteine; Development; Disease; Doctor of Philosophy; Elements; Environment; European; Exposure to; Flavoring; France; Functional disorder; Generations; Homeostasis; Human; International; Italy; Lead; Link; Location; Maine; Malignant Neoplasms; Methodology; Methods; Modification; Molecular; Molecular Carcinogenesis; New England; Nitrogen; Outcome; Oxidation-Reduction; Oxidative Stress; Oxygen; Pathologic Processes; Pathway interactions; Phosphoric Monoester Hydrolases; Phosphorylation; Phosphotransferases; Physicians; Physiological Processes; Physiology; Process; Property; Proteins; Reaction; Reactive Oxygen Species; Regulation; Request for Applications; Request for Proposals; Research; Research Personnel; Schedule; Scientist; Signal Transduction; Site; Stress; Sulfhydryl Compounds; Sulfur; Technology; Therapeutic; Work; age related; base; college; disulfide bond; environmental agent; environmental toxicology; frontier; graduate student; improved; interest; meetings; member; oxidation; protein folding; protein function; public health relevance; success; symposium; transcription factor; tumor progression

DESCRIPTION (provided by applicant) This proposal requests support for the Fourth Gordon Research Conference (and first associated Gordon Research Seminar) on Thiol-based Redox Regulation and signaling to be held at Bates College in Lewiston, Maine, from July 28th to August 3rd, 2012. The subtitle of this conference, "Molecular Underpinnings of Redox Regulation and Oxidative Stress," reflects the focus of the upcoming meeting on the interplay between regulation of protein function and fundamental cellular processes through redox modifications on thiols, and the dysregulation that ensues under environmental conditions that exacerbate oxidative stress. Thiol-containing proteins are major antioxidants in cells, and reversible oxidation of thiols in phosphatases, kinases and transcription factors links thiol-based redox chemistry to phosphorylation-based signaling, cell proliferation, apoptosis, gene regulation, cell cycle control and other processes and pathways. Dysregulation of thiol-based redox homeostasis, for example by exposure to environmental agents which promote the generation of excessive damaging reactive oxygen species, may impart an element of irreversibility to redox regulation and has major implications for the onset and progression of cancer and complex age-related diseases. This interdisciplinary conference is in its fourth cycle after three very successful meetings in the U.S. (2006) and Italy (2008 and 2010), and will provide, as it has in the past, an important venue for the free exchange of ideas and methodologies among the molecular biologists and toxicologists, chemists and clinicians working on various aspects of the field. While the thematic area of the conference is broad-based, its relevance to environmental stress, carcinogenesis and the molecular basis for normal human physiology and disease is enormous. By bringing together investigators with varied expertise in biophysical methods, bioinformatics and animal model systems, with clinical researchers and physicians focused on disease processes, the meeting is expected to further stimulate collaborations and catalyze scientific progress as has been exemplified by the successes of the previous meetings. Public Health Relevance: Many cellular functions rely on processes that involve changes in redox properties of particular molecules within the cell, and the dysregulation of these processes is a major component of the onset and progression of aging and cancer. One amino acid, cysteine (which contains a thiol group), serves as a molecular switch and is central to these redox changes, although very few molecular details of which redox changes occur during normal and pathological processes are known. This conference brings together chemists, molecular biologists and toxicologists, and clinicians to promote the sharing of different levels of understanding of thiol-dependent processes and enable therapeutic benefits to be gained from our improved understanding.

描述（由申请人提供） 该提案要求支持将于2012年7月28日至8月3日在缅因州刘易斯顿贝茨学院举行的关于硫醇基氧化还原调节和信号传导的第四届戈登研究会议（以及第一次相关的戈登研究研讨会）。本次会议的副标题，“氧化还原调节和氧化应激的分子基础”，反映了即将举行的会议对蛋白质功能的调节和基本细胞过程之间的相互作用，通过对硫醇的氧化还原修饰，以及在环境条件下加剧氧化应激的失调。含巯基蛋白质是细胞中的主要抗氧化剂，并且磷酸酶、激酶和转录因子中巯基的可逆氧化将基于巯基的氧化还原化学与基于磷酸化的信号传导、细胞增殖、凋亡、基因调控、细胞周期控制和其他过程和途径相联系。 基于硫醇的氧化还原稳态的失调，例如通过暴露于促进过度破坏性活性氧物质的产生的环境因子，可以赋予氧化还原调节不可逆性的元素，并且对癌症和复杂的年龄相关疾病的发作和进展具有重要意义。这个跨学科的会议是在美国（2006年）和意大利（2008年和2010年）三次非常成功的会议后的第四个周期，并将提供，因为它在过去，为分子生物学家和毒理学家，化学家和临床医生在该领域的各个方面工作的思想和方法的自由交流的重要场所。 虽然会议的主题领域是基础广泛的，但它与环境压力、致癌作用和正常人类生理和疾病的分子基础的相关性是巨大的。 通过汇集在生物物理方法，生物信息学和动物模型系统方面具有不同专业知识的研究人员，以及专注于疾病过程的临床研究人员和医生，预计会议将进一步促进合作并促进科学进步，正如以前会议所取得的成功。 公共卫生相关性：许多细胞功能依赖于涉及细胞内特定分子氧化还原特性变化的过程，这些过程的失调是衰老和癌症发生和发展的主要组成部分。 一种氨基酸，半胱氨酸（含有巯基），作为一个分子开关，是这些氧化还原变化的核心，虽然很少的分子细节，氧化还原变化发生在正常和病理过程中是已知的。本次会议汇集了化学家，分子生物学家和毒理学家，以及临床医生，以促进对硫醇依赖过程的不同层次的理解的共享，并使我们能够从更好的理解中获得治疗益处。