Human Exposure and Responses to Toxins from the Air and Water

人类对空气和水中毒素的接触和反应

• 批准号: 8202506
• 负责人: Ashis K Basu
• 金额: $ 0.8万
• 依托单位: UNIVERSITY OF CONNECTICUT STORRS
• 依托单位国家: 美国
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-08-01 至 2012-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8202506
• 关键词: Address; Air; American; Area; Arsenic; Award; Biological Markers; Biology; Chemicals; Chemistry; Detection; Development; Disease; Endocrine; Endocrine Disruptors; Environment; Environmental Exposure; Environmental Health; Event; Exposure to; Health; Link; Malignant Neoplasms; Metabolism; Mission; Molecular; Mutation; National Institute of Environmental Health Sciences; Oxidation-Reduction; Paper; Pharmaceutical Preparations; Postdoctoral Fellow; Prevention; Process; Reactive Oxygen Species; Request for Applications; Research; Research Personnel; Scientist; Signal Transduction; Societies; Students; Technology; Toxic effect; Toxicology; Toxin; Training; Translating; Water; Work; base; carcinogenesis; environmental agent; exposed human population; interest; meetings; member; posters; professor; programs; public health relevance; response; structural biology; symposium

DESCRIPTION (provided by applicant) This application requests partial support for programming of the Division of Chemical Toxicology of the American Chemical Society at its 242nd National Meeting and Exposition in Denver, CO from Sunday, August 28, 2011 to Wednesday, August 31, 2011. A unique feature of this ACS meeting is the broad theme of the entire meeting "Air, Space and Water," with events planned across the programming of all ACS divisions. The mission of the ACS Division of Chemical Toxicology is to promote the understanding of chemical mechanisms that contribute to disease processes including cancer and the toxicity of environmental agents, drugs and endogenous chemicals. The division integrates work in chemistry, chemical biology, structural biology, toxicology, environmental health sciences and disease mechanisms. Based on the ACS theme, the Division of Toxicology theme for this meeting is "Human Exposure and Responses to Toxins from the Air and Water." This theme aligns closely with the core focus areas of the Division and provides content of interest to the members including students and postdoctoral fellows. In addition to dissemination of the most recent scientific results and ideas, the division has a strong commitment to train young budding scientists. Five interrelated sessions are planned, which include invited talks by a diverse group of leading established and up-and- coming scientists presenting their recent research results. Two sessions have especially strong relevance to the mission of the NIEHS. The first (Monday afternoon Symposium) "Arsenic Metabolism and Health Effects" addresses various aspects of arsenic toxicity and carcinogenesis, and is also of interest to the NCI. The second entitled "Endocrine Disruptors" addresses another important environmental issue. The recipient of Founder's Award this year is F. Peter Guengerich. He organized the "Founder's Award Symposium" that has relevance to metabolism, toxicity, and mutation, topics of interest to both the NIEHS and NCI. The symposium on "Redox Toxicity" is of interest to the NCI. An all-day bioanalytical session, entitled "Bioanalytical Platforms in Biomarker Discovery and Development," focuses on state-of- the-art technology of detection and is of interest to both the NIEHS and NCI. Proffered paper sessions and a Young Investigators Symposium offer opportunities for young investigators to present their primary contributions. Public Health Relevance: Effective prevention and treatment of environmentally-related diseases requires an understanding of underlying mechanisms that link environmental exposures to disease mechanisms. This meeting of the Division of Chemical Toxicology of the American Chemical Society will examine the chemical mechanisms by which molecular damage translates to diseases including cancer. Specifically, the sponsored symposia will examine new work on how molecular damage processes by arsenic, reactive oxygen species, or endocrine active chemicals in the environment create signals that trigger disease processes.

描述（由申请人提供） 该申请要求在2011年8月28日至2011年8月31日星期三在科罗拉多州丹佛市举行的美国化学学会化学毒理学分公司进行部分支持，以编程美国化学学会的化学毒理学分公司。该ACS会议的一个独特特征是整个ACS分区计划的广泛主题“空中，太空和水”的广泛主题。 ACS化学毒理学分区的使命是促进对促进疾病过程的化学机制的理解，包括癌症和环境药物，药物和内源性化学物质的毒性。该部门整合了化学，化学生物学，结构生物学，毒理学，环境健康科学和疾病机制的工作。基于ACS主题，这次会议的毒理学主题是“人类暴露和对空气和水的毒素反应”。该主题与该部门的核心重点领域紧密相符，并为成员提供感兴趣的内容，包括学生和博士后研究员。除了传播最新的科学结果和思想外，该部门还致力于培训年轻的萌芽科学家。计划了五个相互关联的会议，其中包括由一系列领先的成立和即将到来的科学家进行的邀请演讲，呈现了他们最近的研究结果。两次会议与NIEHS的使命特别有意义。第一个（星期一下午的研讨会）“砷代谢和健康效应”涉及砷毒性和致癌的各个方面，也是NCI感兴趣的。第二个标题为“内分泌破坏者”解决了另一个重要的环境问题。今年创始人奖的获得者是F. Peter Guengerich。他组织了与NIEHS和NCI有关的新陈代谢，毒性和突变，感兴趣的主题的“创始人奖”研讨会。 NCI的“氧化还原毒性”研讨会引起了人们的关注。 全天的生物分析会议，题为“生物标志物发现和开发中的生物分析平台”，重点介绍了最先进的检测技术，并且对NIEHS和NCI都很感兴趣。提供的纸质会议和年轻的调查人员研讨会为年轻调查人员提供了他们的主要贡献的机会。 公共卫生相关性：有效的预防和治疗环境相关疾病需要了解将环境暴露与疾病机制联系起来的基本机制。美国化学学会化学毒理学的这一会议将检查分子损伤转化为包括癌症的疾病的化学机制。 具体而言，赞助的研讨会将研究有关在环境中砷，活性氧或内分泌活性化学物质如何产生触发疾病过程的信号的新工作。