International RUNX Workshop

国际RUNX研讨会

• 批准号: 8129107
• 负责人: DONG-ER ZHANG
• 金额: $ 1万
• 依托单位: UNIVERSITY OF CALIFORNIA, SAN DIEGO
• 依托单位国家: 美国
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-07-01 至 2011-12-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8129107
• 关键词: Acute Myelocytic Leukemia; Area; Binding; Biological; Biological Models; Biology; Blood; Blood Platelets; Bone Diseases; Brain; California; Cancer Biology; Cell Survival; Cells; Chromosomal translocation; Chromosome abnormality; Collaborations; Complex; DNA; DNA Binding; Development; Developmental Biology; Disabled Persons; Discipline; Disease; Drosophila genus; Educational workshop; Embryo; Environment; Eye; Family; Family member; Fishes; Friendships; Functional disorder; Future; Gene Expression; Genes; Genetic; Group Meetings; Hair; Hematopoiesis; Human; International; Knowledge; Malignant Neoplasms; Mentors; Modeling; Mus; Mutation; Normal Cell; Pathway interactions; Play; Process; Proteins; RUNX1 gene; Regulation; Research; Research Activity; Research Personnel; Resource Sharing; Resources; Role; Science; Scientist; Societies; Solid Neoplasm; Stem cells; Structure; System; Systems Biology; Therapeutic; Therapeutic Intervention; Underrepresented Minority; United States National Institutes of Health; Vertebrates; Work; base; body system; bone; cancer stem cell; career; cell behavior; cell fate specification; drug discovery; human disease; interest; leukemia; leukemia/lymphoma; meetings; novel; osteosarcoma; programs; role model; skeletal disorder; stem; stem cell differentiation; stem cell fate; structural biology; symposium; t(8; 21)(q22; q22); transcription factor; virology; working group

DESCRIPTION (provided by applicant): This application is to request partial support from the National Institutes of Health for the "18th International RUNX Workshop". The workshop will take place in La Jolla, California in August of 2011. The meeting will bring together scientists around the world working in a variety of scientific fields and using different model systems to discuss the role of the RUNX family of transcription factors in normal cell behavior and human disease development, and to discuss therapeutic approaches for RUNX-related diseases, such as leukemia, solid tumors, familial platelet problems and bone disorders. With the exception of the RUNX workshop, most of the attending scientists do not have any opportunities to meet in other scientific conferences, due to the extremely diversified areas of research. The significance of this family of transcription factors stems from their function as master regulators of multiple cellular programs during development and differentiation, and from their dominant function when altered in the development of cancer. This workshop has been organized annually since 1994. It provides a unique forum for the exchange of ideas and resources across biological disciplines and model systems. The attendance has increased markedly from the five research groups that met in the inaugural workshop at Dartmouth in 1994 to include 120 investigators in recent years. According to our current knowledge of RUNX function and the most exciting areas of ongoing research activities, the upcoming 18th International RUNX Workshop will focus on following areas: 1) Stem cell survival and expansion; 2) Mechanisms of cell-fate specification in development and differentiation; 3) Hematopoiesis, leukemia and lymphoma; 4) Cancer and cancer stem cells; 5) Bone biology, osteosarcomas and skeletal disorders; and 6) Systems biology, structure biology and drug discovery. Based on the long-standing interactive and inter-disciplinary traditions of the 17 previous RUNX workshops, we anticipate that the 18th International RUNX Workshop will offer excellent opportunities for the cross-pollination of ideas and the development of new collaborations in this rapidly expanding field. PUBLIC HEALTH RELEVANCE: RUNX proteins play key regulatory roles in a number of essential developmental pathways. Importantly, perturbations in RUNX function have been shown to be causally associated with a number of different human diseases, including effects on the differentiation of stem cells in multiple lineages and the development of a variety of leukemias, solid tumors and bone disorders. The complexity in their expression, regulation and function has made the RUNX genes a focus of study of several fields of research, including developmental biology, virology, genetics, structural biology, cancer biology, systems biology and more recently in therapeutic interventions.

描述（由申请人提供）：本申请旨在请求美国国立卫生研究院对“第18届国际RUNX研讨会”的部分支持。该研讨会将于 2011 年 8 月在加利福尼亚州拉霍亚举行。会议将汇集世界各地在各个科学领域工作并使用不同模型系统的科学家，讨论 RUNX 转录因子家族在正常细胞行为和人类疾病发展中的作用，并讨论 RUNX 相关疾病的治疗方法，例如白血病、实体瘤、家族性血小板问题和骨病。除了 RUNX 研讨会之外，由于研究领域极其多元化，大多数与会科学家没有任何机会在其他科学会议上见面。该转录因子家族的重要性源于它们在发育和分化过程中作为多个细胞程序的主调节因子的功能，以及它们在癌症发展过程中改变时的主导功能。该研讨会自 1994 年以来每年举办一次。它为生物学科和模型系统之间的思想和资源交流提供了一个独特的论坛。从 1994 年在达特茅斯首次研讨会上召开的 5 个研究小组到近年来的 120 名研究人员，出席人数显着增加。根据我们目前对RUNX功能的了解以及正在进行的研究活动中最令人兴奋的领域，即将举行的第18届国际RUNX研讨会将重点关注以下领域：1）干细胞存活和扩增； 2）发育和分化过程中细胞命运规范的机制； 3）造血、白血病、淋巴瘤； 4）癌症和癌症干细胞； 5）骨生物学、骨肉瘤和骨骼疾病； 6) 系统生物学、结构生物学和药物发现。基于前 17 届 RUNX 研讨会长期以来的互动和跨学科传统，我们预计第 18 届国际 RUNX 研讨会将为这一快速扩展的领域的思想交叉和新合作的发展提供绝佳的机会。 公共卫生相关性：RUNX 蛋白在许多重要的发育途径中发挥着关键的调节作用。重要的是，RUNX 功能的扰动已被证明与许多不同的人类疾病有因果关系，包括对多个谱系干细胞分化的影响以及各种白血病、实体瘤和骨疾病的发展。其表达、调控和功能的复杂性使得RUNX基因成为多个研究领域的研究焦点，包括发育生物学、病毒学、遗传学、结构生物学、癌症生物学、系统生物学以及最近的治疗干预。