International RUNX Workshop

描述（由申请人提供）：本申请是为了请求美国国立卫生研究院对“第18届国际RUNX研讨会”的部分支持。研讨会将于2011年8月在加州的拉霍亚举行。会议将汇集世界各地的科学家，他们在不同的科学领域工作，并使用不同的模型系统来讨论RUNX家族转录因子在正常细胞行为和人类疾病发展中的作用，并讨论RUNX相关疾病的治疗方法，如白血病，实体瘤，家族性血小板问题和骨骼疾病。除了RUNX研讨会之外，由于研究领域极其多样化，大多数与会科学家没有机会在其他科学会议上见面。这个转录因子家族的重要性源于它们在发育和分化期间作为多个细胞程序的主调节器的功能，以及它们在癌症发展中改变时的主导功能。自1994年以来，每年都举办这一讲习班。它为跨生物学科和模型系统的思想和资源交流提供了一个独特的论坛。1994年在达特茅斯举行的首届研讨会上，参加研讨会的五个研究小组明显增加，近年来有120名研究人员参加。根据我们目前对RUNX功能的了解和正在进行的最令人兴奋的研究活动领域，即将举行的第18届国际RUNX研讨会将集中在以下领域：1）干细胞存活和扩增; 2）发育和分化中细胞命运特化的机制; 3）造血、白血病和淋巴瘤; 4）癌症和癌症干细胞; 5）肿瘤干细胞; 6）肿瘤干细胞; 7）肿瘤干细胞; 8）肿瘤干细胞; 9）肿瘤干细胞; 10）肿瘤干细胞; 11）肿瘤干细胞; 12）肿瘤干细胞; 13）肿瘤干细胞; 14）肿瘤干细胞。5）骨生物学、骨肉瘤和骨骼疾病;和6）系统生物学、结构生物学和药物发现。基于前17届RUNX研讨会长期以来的互动和跨学科传统，我们预计第18届国际RUNX研讨会将为思想的交叉授粉和在这个快速发展的领域发展新的合作提供绝佳的机会。 公共卫生相关性：RUNX蛋白在许多重要的发育途径中发挥关键的调节作用。重要的是，RUNX功能的扰动已被证明与许多不同的人类疾病有因果关系，包括对多个谱系中干细胞分化的影响以及各种白血病、实体瘤和骨疾病的发展。RUNX基因表达、调控和功能的复杂性使其成为多个研究领域的研究焦点，包括发育生物学、病毒学、遗传学、结构生物学、癌症生物学、系统生物学以及最近的治疗干预。

DESCRIPTION (provided by applicant): This application is to request partial support from the National Institutes of Health for the "18th International RUNX Workshop". The workshop will take place in La Jolla, California in August of 2011. The meeting will bring together scientists around the world working in a variety of scientific fields and using different model systems to discuss the role of the RUNX family of transcription factors in normal cell behavior and human disease development, and to discuss therapeutic approaches for RUNX-related diseases, such as leukemia, solid tumors, familial platelet problems and bone disorders. With the exception of the RUNX workshop, most of the attending scientists do not have any opportunities to meet in other scientific conferences, due to the extremely diversified areas of research. The significance of this family of transcription factors stems from their function as master regulators of multiple cellular programs during development and differentiation, and from their dominant function when altered in the development of cancer. This workshop has been organized annually since 1994. It provides a unique forum for the exchange of ideas and resources across biological disciplines and model systems. The attendance has increased markedly from the five research groups that met in the inaugural workshop at Dartmouth in 1994 to include 120 investigators in recent years. According to our current knowledge of RUNX function and the most exciting areas of ongoing research activities, the upcoming 18th International RUNX Workshop will focus on following areas: 1) Stem cell survival and expansion; 2) Mechanisms of cell-fate specification in development and differentiation; 3) Hematopoiesis, leukemia and lymphoma; 4) Cancer and cancer stem cells; 5) Bone biology, osteosarcomas and skeletal disorders; and 6) Systems biology, structure biology and drug discovery. Based on the long-standing interactive and inter-disciplinary traditions of the 17 previous RUNX workshops, we anticipate that the 18th International RUNX Workshop will offer excellent opportunities for the cross-pollination of ideas and the development of new collaborations in this rapidly expanding field. PUBLIC HEALTH RELEVANCE: RUNX proteins play key regulatory roles in a number of essential developmental pathways. Importantly, perturbations in RUNX function have been shown to be causally associated with a number of different human diseases, including effects on the differentiation of stem cells in multiple lineages and the development of a variety of leukemias, solid tumors and bone disorders. The complexity in their expression, regulation and function has made the RUNX genes a focus of study of several fields of research, including developmental biology, virology, genetics, structural biology, cancer biology, systems biology and more recently in therapeutic interventions.