2011 Stress Proteins in Growth, Development and Disease GRC

2011 生长、发育和疾病 GRC 中的应激蛋白

• 批准号: 8193579
• 负责人: JUDITH FRYDMAN
• 金额: $ 1.5万
• 依托单位: GORDON RESEARCH CONFERENCES
• 依托单位国家: 美国
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-06-15 至 2012-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8193579
• 关键词: Affect; African American; Age; Aging; Alzheimer' s Disease; Area; Biochemical; Biological Models; Biology; Cattle; Cell Aging; Cells; Cellular Stress Response; Cellular biology; Collaborations; Commit; Communities; Country; Creutzfeldt-Jakob Syndrome; Data; Defect; Degenerative Disorder; Development; Disease; Ensure; Environment; Europe; Evaluation; Exhibits; Finland; Gene Activation; Gene Expression; Generations; Genes; Growth and Development function; Health; Heat shock proteins; Human; Huntington Disease; Infection; Intervention; Italy; Lead; Life; Light; Link; Malignant Neoplasms; Metabolic Diseases; Metabolism; Molecular; Molecular Chaperones; Names; Neurodegenerative Disorders; Neurons; Nutrient; Oral; Organism; Oxidative Stress; Parkinson Disease; Participant; Pathway interactions; Physiological; Physiology; Plants; Play; Postdoctoral Fellow; Process; Protein Dynamics; Proteins; Recording of previous events; Regulation; Request for Applications; Research; Research Personnel; Resort; Role; Schedule; Science; Scientist; Series; Signal Transduction; Site; Sodium Chloride; Stress; Structure; System; Techniques; Time; Ubiquitin; Underrepresented Minority; Universities; Water Stress; Woman; Work; abstracting; age group; age related; base; biological adaptation to stress; cell age; graduate student; human disease; meetings; microbial; multicatalytic endopeptidase complex; nervous system disorder; polyglutamine; polypeptide; posters; preference; prevent; prion-based; protein folding; protein function; rapid growth; stress protein; symposium; transcription factor

DESCRIPTION (provided by applicant): The ability of organisms to withstand stress is critical for survival, and there is a growing appreciation that cellular stress responses are vital during growth and development. In fact, an increasing number of human diseases-particularly those affecting neurons-arise from defects in stress response pathways or from the inability of stress proteins to protect cells. Stress response pathways have also been linked to ageing, infection, cancer, and metabolic diseases. Not surprisingly, then, significant efforts to modulate the stress response have been taken by biomedical researchers. Therefore, it is critical that a forum is provided to assemble scientists who seek to connect the mechanisms underlying human diseases with the regulation of stress genes and with stress protein function. One of the premier forums for this unique assembly is the Stress Proteins in Growth, Development and Disease Gordon Research Conference (GRC). The next conference, which is the sixth in this series, will be held from July 17th - July 22nd, 2011, at the Il Ciocco Hotel & Resort, Lucca (Barga), Italy. The Chair for this meeting is Lea Sistonen (Ebo Akademi University, Turku, Finland) and the Vice-Chair is Judith Frydman (Stanford University, Stanford, CA). The Il Ciocco Hotel has a long history in supporting GRCs conferences. Thus far, 30 internationally recognized speakers have committed to attending and speaking at the 2011 meeting, including 10 women and one African-American. Nevertheless, significant efforts will be undertaken to increase the diversity of meeting attendees, to bring more scientists into the stress protein field, and to catalyze the formation of new collaborations. To this end, the schedule has been prepared so that 16 speaking slots will be chosen from abstracts submitted for poster presentations, and preference will be given to younger scientists and to those from under- represented groups. The meeting schedule will also be prepared to ensure that new and emerging themes in stress biology and different model systems are equally represented. In addition, meeting attendance will be "capped" at 150 to facilitate effective interactions and discussions. Overall, we seek to enhance the dissemination of cutting-edge advances and the formation of new collaborations in the stress protein field. This, in turn, will lead to advances and broaden our understanding of the roles of stress proteins in human health, aging, and disease. PUBLIC HEALTH RELEVANCE: Cells-especially neurons-live under harsh conditions. There are times when cells are starved for nutrients, times when cells need to exhibit rapid growth, and times when cells are exposed to toxic agents. Cells may also express misshapen proteins, as occurs in Alzheimer's, Huntington's, and Parkinson's disease. However, to offset the dangerous consequences of stress, which can lead not only to disease but also to ageing, cells produce specific proteins to protect themselves. The 2011 Gordon Research Conference, entitled 3Stress Proteins in Growth, Development, and Disease4, brings together scientists who study the link between stress and human disease, and provides a unique forum for researchers in this field to assemble and identify new avenues to prevent stress-related diseases and degenerative processes such as aging.

描述（由申请人提供）：生物体承受压力的能力对于生存至关重要，并且越来越多的人认识到细胞压力反应在生长和发育过程中至关重要。事实上，越来越多的人类疾病，特别是那些影响神经元的疾病，是由于应激反应途径的缺陷或应激蛋白无法保护细胞而引起的。压力反应途径也与衰老、感染、癌症和代谢疾病有关。因此，生物医学研究人员在调节应激反应方面做出了重大努力，这也就不足为奇了。因此，至关重要的是，提供一个论坛，聚集科学家谁寻求人类疾病的机制与应激基因的调节和应激蛋白质的功能连接。这个独特的大会的首要论坛之一是生长，发育和疾病戈登研究会议（GRC）的应激蛋白。下一次会议，这是该系列的第六次，将于2011年7月17日至7月22日在意大利卢卡（巴尔加）的Il Ciocco Hotel & Resort举行。本次会议主席为莱亚·西斯托宁（芬兰图尔库埃博学术大学），副主席为朱迪思·弗里德曼（加利福尼亚州斯坦福大学斯坦福大学）。Il Ciocco Hotel酒店在支持GRCs会议方面有着悠久的历史。迄今为止，已有30名国际知名的发言者承诺出席2011年会议并发言，其中包括10名妇女和1名非洲裔美国人。尽管如此，我们仍将做出重大努力，增加与会者的多样性，让更多的科学家进入应激蛋白领域，并促进新的合作。为此目的，在编制时间表时，将从提交的海报介绍摘要中选出16个发言时段，并将优先考虑年轻科学家和来自代表性不足群体的科学家。会议时间表也将准备，以确保压力生物学和不同的模型系统中的新的和新兴的主题得到平等的代表。此外，会议出席人数将以150人为上限，以促进有效的互动和讨论。总的来说，我们寻求加强尖端进展的传播，并在应激蛋白领域形成新的合作。反过来，这将导致进步，并扩大我们对应激蛋白在人类健康，衰老和疾病中的作用的理解。 公共卫生相关性：细胞，特别是神经元，在恶劣的条件下生存。有时细胞缺乏营养，有时细胞需要快速生长，有时细胞暴露于有毒物质。细胞也可能表达畸形蛋白质，如阿尔茨海默氏症、亨廷顿氏症和帕金森氏症。然而，为了抵消压力的危险后果，不仅会导致疾病，还会导致衰老，细胞会产生特定的蛋白质来保护自己。2011年戈登研究会议，题为3Stress Proteins in Growth，Development，and Disease4，汇集了研究压力和人类疾病之间联系的科学家，并为该领域的研究人员提供了一个独特的论坛，以收集和确定预防压力相关疾病和衰老等退行性过程的新途径。