2013 Stress Proteins in Growth, Development & Disease Gordon Research Conference

描述（由申请人提供）：细胞蛋白质组持续暴露于各种毒性应激。这些包括外部应力，例如升高的温度、辐射损伤和药理学试剂以及在细胞增殖、分化、炎症和衰老期间遇到的生理应力。在所有生物体中，应激反应的诱导对于维持蛋白质稳态是必不可少的，并且应激反应的调节在寿命调节和与衰老相关的疾病如阿尔茨海默氏症、帕金森氏症和亨廷顿氏症中起关键作用。2013年戈登会议“生长，发育和疾病中的应激蛋白质”正在成为这一研究领域最令人兴奋和最重要的会议之一。它将突出该领域的许多前沿进展，强调广泛的主题，包括与压力传感，信号传导和基因表达有关的令人兴奋的发展，蛋白质折叠和构象疾病，压力基因在代谢，生长和发育中的作用，压力基因对感染和病理生理状态的调节，压力的细胞生物学以及压力在衰老中的作用。本次会议是该系列的第七次会议，将于7月7日至12日在佛蒙特州西多佛的雪山度假村举行。会议主席是Judith Frydman博士（斯坦福大学，斯坦福大学，加利福尼亚州），共同主席是Ursula Jakob博士（密歇根大学，安阿伯，密歇根州）。到目前为止，34位国际公认的发言者已承诺出席2013年会议并在会上发言，其中包括9名妇女和1名非裔美国人。此外，还将做出重大努力，增加会议与会者的多样性，带来更多 科学家进入应激蛋白领域，并促进新的合作的形成。为此目的，已编制了时间表，以便从提交的海报介绍摘要中选出10个发言时段，并将优先考虑年轻科学家和来自代表性不足群体的科学家。会议时间表也将准备，以确保压力生物学和不同的模型系统中的新的和新兴的主题得到平等的代表。此外，会议出席人数将以200人为上限，以促进有效的互动和讨论。正式的科学计划加上更多的非正式讨论将促进新信息的传播和新合作的形成，这对于更深入地了解应激蛋白在人类健康，衰老和疾病中的多方面作用是非常宝贵的。

DESCRIPTION (provided by applicant): The cellular proteome is constantly exposed to a wide variety of toxic stresses. These include external stresses, such as elevated temperatures, radiation damage and pharmacological agents as well as physiological stresses encountered during cellular proliferation, differentiation, inflammation and aging. In all organisms, inductionof the stress response is essential for the maintenance of protein homeostasis and modulation of the stress response plays a critical role in life-span regulation and aging-related diseases such as Alzheimer's, Parkinson's and Huntington's disease. The 2013 Gordon Conference on "Stress Proteins in Growth, Development & Disease" is shaping up to be one of the most exciting and important meetings in this research area. It will highlight the many cutting edge advances in the field, emphasizing a broad range of topics, including exciting developments related to stress sensing, signaling, and gene expression, diseases of protein folding and conformation, roles of stress genes in metabolism, growth and development, stress gene modulation of infection and pathophysiological states, the cell biology of stress, and the roles of stress in aging. This conference, which is the seventh in this series, will be held July 7th-12th at the Mount Snow Resort in West Dover, Vermont. The chair of this meeting is Dr. Judith Frydman (Stanford University, Stanford, CA) and the co-chair is Dr. Ursula Jakob (University of Michigan, Ann Arbor, MI). Thus far, 34 internationally recognized speakers have committed to attending and speaking at the 2013 meeting, including 9 women and one African- American. Moreover, significant effort will be undertaken to increase the diversity of meeting attendees, to bring more scientists into the stress protein field, and to catalyze the formation of new collaborations. To this end, the schedule has been prepared so that 10 speaking slots will be chosen from abstracts submitted for poster presentations, and preference will be given to younger scientists and to those from under-represented groups. The meeting schedule will also be prepared to ensure that new and emerging themes in stress biology and different model systems are equally represented. In addition, meeting attendance will be "capped" at 200 to facilitate effective interactions and discussions. The formal scientific program together with more informal discussions will enhance the dissemination of new information and the formation of new collaborations, which are invaluable for deeper understanding of the versatile roles of stress proteins in human health, aging and disease.