MM-CPN - TYPE II CHAPERONIN
MM-CPN - TYPE II CHAPERONIN
批准号:
8361101
负责人:
JUDITH FRYDMAN
金额:
$6.13万
依托单位国家:
美国
项目类别:
财政年份:
2011
资助国家:
美国
项目状态:
已结题
起止时间:
2011-01-01 至 2011-12-31
关键词:
ATP HydrolysisArchaeaBackChemicalsElectron MicroscopyEukaryotaEventFundingGrantMediatingMediator of activation proteinNational Center for Research ResourcesPrincipal InvestigatorProtein IsoformsProteinsResearchResearch InfrastructureResolutionResourcesSourceStructureUnited States National Institutes of Healthchaperonincostmacromoleculemolecular rearrangementpolypeptideprotein folding
中文摘要
该子项目是利用资源的许多研究子项目之一
由NIH/NCRR资助的中心拨款提供。次级项目的主要支助
而子项目的主要调查员可能是由其他来源提供的,
包括其它NIH来源。 列出的子项目总成本可能
表示子项目使用的中心基础设施的估计数量,
而不是由NCRR赠款提供给子项目或子项目工作人员的直接资金。
Mm-cpn是一种约1 MDa的胰岛II型伴侣蛋白。它的结构组织比较简单
比TRIC,哺乳动物II型伴侣蛋白,因为,虽然也是16聚体,
只有一个亚单位同种型。II类伴侣蛋白是细胞蛋白质的重要介质
真核生物和古细菌中的折叠。这些寡聚蛋白机器,约1 MDa,由以下组成:
两个背靠背的环,围绕容纳多肽的中心腔
印刷受体. 伴侣蛋白介导的蛋白质折叠严重依赖于蛋白质折叠的闭合。
内置的盖子,这是触发ATP水解。结构重组和
导致眼睑闭合的分子事件仍然是未知的。我们建议确定其
在近原子分辨率的不同化学状态下的结构。
英文摘要
This subproject is one of many research subprojects utilizing the resources
provided by a Center grant funded by NIH/NCRR. Primary support for the subproject
and the subproject's principal investigator may have been provided by other sources,
including other NIH sources. The Total Cost listed for the subproject likely
represents the estimated amount of Center infrastructure utilized by the subproject,
not direct funding provided by the NCRR grant to the subproject or subproject staff.
Mm-cpn is an Archaeal type II chaperonin of ~1 MDa. Its structural organization is simpler
than TRIC, the mammalian type II chaperonin, because, while also a 16mer, it possesses
only a single subunit isoform. Group II chaperonins are essential mediators of cellular protein
folding in eukaryotes and archaea. These oligomeric protein machines, ~1MDa, consist of
two back-to-back rings encompassing a central cavity that accommodates polypeptide
substrates. Chaperonin-mediated protein folding is critically dependent on the closure of a
built-in lid, which is triggered by ATP hydrolysis. The structural rearrangements and
molecular events leading to lid closure are still unknown. We propose to determine its
structures in different chemical states at near atomic resolution.
期刊论文(0)
专著(0)
科研奖励(0)
会议论文
Building a Toolbox of Sensors and Approaches to Monitor the Proteostasis Network Core B
-
批准号:10432028
-
项目类别:
-
资助金额:$25.07万
-
财政年份:2018
-
负责人:JUDITH FRYDMAN
-
依托单位:
Dissecting the aging-associated decline in cellular proteostasis - Project 1
-
批准号:10432032
-
项目类别:
-
资助金额:$42.19万
-
财政年份:2018
-
负责人:JUDITH FRYDMAN
-
依托单位:
Dissecting the aging-associated decline in cellular proteostasis - Project 1
-
批准号:10183114
-
项目类别:
-
资助金额:$42.87万
-
财政年份:2018
-
负责人:JUDITH FRYDMAN
-
依托单位:
Building a Toolbox of Sensors and Approaches to Monitor the Proteostasis Network Core B
-
批准号:10183111
-
项目类别:
-
资助金额:$25.36万
-
财政年份:2018
-
负责人:JUDITH FRYDMAN
-
依托单位:
Defining the role of Host Hsp70 Subnetworks in Dengue Virus Replication
-
批准号:9215112
-
项目类别:
-
资助金额:$44.55万
-
财政年份:2016
-
负责人:JUDITH FRYDMAN
-
依托单位:
Defining the role of Host Hsp70 Subnetworks in Dengue Virus Replication
-
批准号:10054971
-
项目类别:
-
资助金额:$49.65万
-
财政年份:2016
-
负责人:JUDITH FRYDMAN
-
依托单位:
2013 Stress Proteins in Growth, Development & Disease Gordon Research Conference
-
批准号:8597489
-
项目类别:
-
资助金额:$3.5万
-
财政年份:2013
-
负责人:JUDITH FRYDMAN
-
依托单位:
EUKARYOTIC CHAPERONIN
-
批准号:8361063
-
项目类别:
-
资助金额:$6.13万
-
财政年份:2011
-
负责人:JUDITH FRYDMAN
-
依托单位:
2011 Stress Proteins in Growth, Development and Disease GRC
-
批准号:8193579
-
项目类别:
-
资助金额:$1.5万
-
财政年份:2011
-
负责人:JUDITH FRYDMAN
-
依托单位:
HUNTINGTIN FIBRIL
-
批准号:8361086
-
项目类别:
-
资助金额:$1.72万
-
财政年份:2011
-
负责人:JUDITH FRYDMAN
-
依托单位:
Role of Cellular Factors in Enterovirus Protein Homeostasis and Function
-
批准号:8062899
-
项目类别:
-
资助金额:$51.03万
-
财政年份:2011
-
负责人:JUDITH FRYDMAN
-
依托单位:
High-Throughput Screening for Modulators of Cytosolic Chaperonin Activity
-
批准号:8063629
-
项目类别:
-
资助金额:$3.88万
-
财政年份:2010
-
负责人:JUDITH FRYDMAN
-
依托单位:
HUNTINGTIN FIBRIL
-
批准号:8168562
-
项目类别:
-
资助金额:$2.15万
-
财政年份:2010
-
负责人:JUDITH FRYDMAN
-
依托单位:
MM-CPN - TYPE II CHAPERONIN
-
批准号:8168592
-
项目类别:
-
资助金额:$6.45万
-
财政年份:2010
-
负责人:JUDITH FRYDMAN
-
依托单位:
EUKARYOTIC CHAPERONIN
-
批准号:8168533
-
项目类别:
-
资助金额:$4.3万
-
财政年份:2010
-
负责人:JUDITH FRYDMAN
-
依托单位:
High-Throughput Screening for Modulators of Cytosolic Chaperonin Activity
-
批准号:7929704
-
项目类别:
-
资助金额:$4.0万
-
财政年份:2010
-
负责人:JUDITH FRYDMAN
-
依托单位:
SOLUTION X-RAY SCATTERING STUDIES ON THE CONFORMATIONAL CHANGE OF EUKARYOTIC AND
-
批准号:8169983
-
项目类别:
-
资助金额:$0.34万
-
财政年份:2010
-
负责人:JUDITH FRYDMAN
-
依托单位:
SOLUTION X-RAY SCATTERING STUDIES ON THE CONFORMATIONAL CHANGE OF EUKARYOTIC AND
-
批准号:7954267
-
项目类别:
-
资助金额:$0.21万
-
财政年份:2009
-
负责人:JUDITH FRYDMAN
-
依托单位:
EUKARYOTIC CHAPERONIN
-
批准号:7953761
-
项目类别:
-
资助金额:$3.48万
-
财政年份:2008
-
负责人:JUDITH FRYDMAN
-
依托单位:
Protein Folding in the Cell
-
批准号:8291029
-
项目类别:
-
资助金额:$0.5万
-
财政年份:2008
-
负责人:JUDITH FRYDMAN
-
依托单位:
海外基金