Barrier Function of Mammalian Skin Gordon Research Conference

项目简介：哺乳动物皮肤屏障功能戈登研究会议是两年一次的盛会，定于2011年8月7日至12日举行第十二届会议。本次会议是关于哺乳动物屏障的主要国际研究论坛。这是一个独特的跨学科会议，吸引了皮肤病学，分子生物学，生物工程和制药科学家来展示和讨论表皮通透性屏障各方面的最新研究。表皮屏障功能最初被认为只是水运动的被动屏障，现在已知它包括各种屏障，调节水、毒素、药物、微生物和紫外线辐射的通过。随着我们对各种表皮屏障的了解不断扩大，以及表皮屏障异常影响的皮肤病数量增加，每次会议都强调了表皮屏障的新方面。广泛而长期的目标：1)推进皮肤屏障研究领域的科学知识。2)培养跨学科的方法来理解和治疗屏障性皮肤疾病。3)培养在障碍科学领域工作的青年科学家。具体目的：1)传播屏障研究的最新科学和临床进展。2)识别，定义和分析该领域最重要和未解决的问题。3)寻找和追求跨学科的研究机会。4)鼓励参与者之间的讨论和合作。5)包括广泛多样的参与者，包括学术界，工业界和政府的代表，以及外国，女性，残疾人和代表性不足的少数民族。项目的健康相关性：每个计划的会议将讨论表皮屏障功能在健康和特定疾病中的作用。因此，这次会议将促进我们对表皮屏障在调节人类皮肤生物学和疾病中的作用的理解，特别是那些涉及表皮屏障之一的疾病（例如，特应性皮炎、鱼鳞病、接触性皮炎、皮肤日晒损伤和皮肤感染）。NIH的资助可能允许我们邀请杰出的研究者来展示他们的研究或主持会议。这笔资金还可以帮助我们实现我们的目标，即支持从事该领域最具创新性项目的初级研究人员。最后，NIH的资金允许从其他非联邦来源补充资金。

DESCRIPTION (provided by applicant): Project Summary: The Barrier Function of Mammalian Skin Gordon Research Conference is a biennial event, scheduled for its twelfth meeting from August 7-12, 2011. This conference is the primary international research forum on the mammalian barrier. It is a uniquely interdisciplinary conference that attracts dermatology, molecular biology, bioengineering and pharmaceutical scientists to present and discuss the latest research on all aspects of the epidermal permeability barrier. Originally thought of only as a passive barrier to water movement, epidermal barrier function now is known to encompass a variety of barriers, regulating passage of water, toxins, drugs, microbes, and ultraviolet radiation. As our understanding of the variety of epidermal barriers has expanded, and the number of skin diseases impacted by epidermal barrier abnormalities has increased, each conference has highlighted new aspects of the barrier. Broad, Long-term Objectives: 1) To advance scientific knowledge in the field of skin barrier research. 2) To foster interdisciplinary approaches to understand and treat barrier-related skin disease. 3) To nurture young scientists working in barrier-related scientific fields. Specific Aims: 1) To disseminate the most recent scientific and clinical advances in barrier research. 2) To identify, define and analyze the most important and unresolved issues in this field. 3) To identify and pursue interdisciplinary research opportunities. 4) To encourage discussion and forge collaboration among participants. 5) To include a broad diversity of participants, including representation of academia, industry and government, as well as foreign, female, disabled and underrepresented minorities. Heath Relatedness of the Project: Each planned session will address epidermal barrier function in health and in specific diseases. Thus, this meeting will advance our understanding of the epidermal barrier's roles in regulating human skin biology and disease, specifically those that involve one of the epidermal barriers (for example, atopic dermatitis, ichthyosis, contact dermatitis, skin sun damage and skin infections). NIH funding may allow us to invite prominent investigators to present their research or chair sessions. This funding may also assist us in our aim to support junior investigators who may be working on the most innovative projects in the field. Finally, NIH funding allows complementary fundraising from other non-federal sources.