2013 Barrier Function of Mammalian Skin Gordon Research Conferences

描述(申请人提供)：项目概要：哺乳动物皮肤屏障功能戈登研究会议是一项两年一度的活动，定于2013年8月18日至23日举行第13次会议。这次会议是关于哺乳动物屏障的主要国际研究论坛。这是一次独特的跨学科会议，吸引了皮肤病、分子生物学、生物工程和制药科学家展示和讨论关于表皮通透性屏障各个方面的最新研究。最初只被认为是 作为水运动的被动屏障，表皮屏障的功能现在已知包括各种屏障，调节水、毒素、药物、微生物和紫外线的通过。随着我们对各种表皮屏障的了解不断扩大，受表皮屏障异常影响的皮肤病的数量也在增加，每次会议都强调了该屏障的新方面。广泛的长期目标：1)促进皮肤屏障研究领域的科学知识。2)促进跨学科方法来了解和治疗与屏障相关的皮肤病。3)培养在屏障相关科学领域工作的青年科学家。具体目标：1)传播屏障研究的最新科学和临床进展。2)确定、界定和分析该领域最重要和尚未解决的问题。3)确定和开展跨学科研究 机遇。4)鼓励与会者之间的讨论和协作。5)吸收各种各样的参与者，包括学术界、工业界和政府的代表，以及外籍、女性、残疾人和代表性不足的少数群体的代表。每一次计划中的会议都将讨论表皮屏障在健康和特定疾病中的功能。因此，这次会议将促进我们对表皮屏障在调节人类皮肤生物学和疾病方面的作用的理解，特别是涉及一种表皮屏障的疾病(例如，特应性皮炎、鱼鳞病、接触性皮炎、皮肤日光损伤和皮肤感染)。NIH的资助使我们能够邀请著名的研究人员来展示他们的研究或主持会议。这笔资金还支持初级调查人员，他们可能正在从事该领域最具创新性的项目。最后，特别是在企业捐款减少的时代，NIH的资金鼓励来自企业和基金会来源的互补性筹款。

DESCRIPTION (provided by applicant): Project Summary: The Barrier Function of Mammalian Skin Gordon Research Conference is a biennial event, scheduled for its thirteenth meeting from August 18-23, 2013. This conference is the primary international research forum on the mammalian barrier. It is a uniquely interdisciplinary conference that attracts dermatology, molecular biology, bioengineering and pharmaceutical scientists to present and discuss the latest research on all aspects of the epidermal permeability barrier. Originally thought of only as a passive barrier to water movement, epidermal barrier function now is known to encompass a variety of barriers, regulating passage of water, toxins, drugs, microbes, and ultraviolet radiation. As our understanding of the variety of epidermal barriers has expanded, and the number of skin diseases impacted by epidermal barrier abnormalities has increased, each conference has highlighted new aspects of the barrier. Broad, Long-term Objectives: 1) To advance scientific knowledge in the field of skin barrier research. 2) To foster interdisciplinary approaches to understand and treat barrier-related skin disease. 3) To nurture young scientists working in barrier-related scientific fields. Specific Aims: 1) To disseminate the most recent scientific and clinical advances in barrier research. 2) To identify, define and analyze the most important and unresolved issues in this field. 3) To identify and pursue interdisciplinary research opportunities. 4) To encourage discussion and forge collaboration among participants. 5) To include a broad diversity of participants, including representation of academia, industry and government, as well as foreign, female, disabled and underrepresented minorities. Each planned session will address epidermal barrier function in health and in specific diseases. Thus, this meeting will advance our understanding of the epidermal barrier's roles in regulating human skin biology and disease, specifically those that involve one of the epidermal barriers (for example, atopic dermatitis, ichthyosis, contact dermatitis, skin sun damage and skin infections). NIH funding allows us to invite prominent investigators to present their research or chair sessions. This funding also supports junior investigators who may be working on the most innovative projects in the field. Finally, especially in these times of reduced corporate giving, NIH funding encourages complementary fundraising from corporate and foundation sources.