Changing Landscape of the Cancer Genome

描述（由申请人提供）：本提案要求支持由Lynda Chin， Christoph Lengauer和Michael Stratton组织的题为“癌症基因组变化景观”的Keystone专题会议，该会议将于2011年6月20日至25日在马萨诸塞州波士顿举行。全球范围内的大规模癌症基因组项目正在获取越来越详细的癌症基因组视图。这些数据有可能改变癌症研究的方方面面。现在的挑战是破译基因组景观教给我们的关于肿瘤的发生、发展和临床行为的信息。这次会议将是第一次专注于大规模癌症基因组项目的会议。除了对癌症的关注，还有对基因组和计算技术的强烈强调。本次会议的目标如下：1)汇集数据生产者和分析人员，分享他们从大规模癌症基因组项目中获得的最新技术和生物学发现，并解决分析这些复杂癌症基因组数据的挑战；2)强调这些基因组数据如何实现基因组的系统或网络视图，以及如何在这些复杂网络的背景下考虑突变模式，揭示对潜在病因的新见解；3)探索癌症基因组学如何影响药物发现和开发。

DESCRIPTION (provided by applicant): This proposal requests support for a Keystone Symposia meeting entitled Changing Landscape of the Cancer Genome, organized by Lynda Chin, Christoph Lengauer and Michael Stratton, which will be held in Boston, Massachusetts from June 20 - 25, 2011. Large scale cancer genomics projects across the globe are capturing increasingly detailed views of the cancer genomes. These data have the potential to transform every aspect of cancer research. The challenges now are to decipher what the genomic landscape is teaching us about the initiation, progression and clinical behavior of a tumor. This meeting will be the first with a singular focus on large scale cancer genomics projects. In addition to a focus on cancer, there is a strong emphasis on genomic and computational technologies. The goals of this meeting are as follows: 1) to bring together the data producers and analysts to share their latest findings, both technical and biological, from large-scale cancer genomic projects and address the challenges of analyzing these complex cancer genomic data; 2) to highlight how these genomic data are enabling a systems or network-view of the genome and how patterns of mutations, considered in the context of these complex networks, are revealing new insight into underlying etiologies; and 3) to explore how cancer genomics can impact on drug discovery and development. PUBLIC HEALTH RELEVANCE: International large-scale genome centers are identifying an ever-growing number of markers and regulators that can potentially transform normal cells into tumor cells. The sheer volume of these data presents technical challenges which require the rapid evolution of novel data-handling techniques. In addition, a wide gap exists between the identification of genomic cancer markers and the ultimate translational endpoint of efficacious drug development. The Keystone Symposia meeting on Changing Landscape of the Cancer Genome fills a need in the scientific community by providing a forum for those researchers who are taking an ambitious approach towards cancer research by conducting large-scale cancer genomics projects and those interested in using the data.