13th Annual Midwest DNA Repair Symposium

描述(由申请者提供)：第13届中西部DNA修复研讨会(AMDRS)将于2011年5月14-15日在俄亥俄州托莱多的托莱多大学健康科学校区达纳会议中心举行。AMDRS于1999年在密歇根大学开始，此后每年都在中西部的多所大学举办。中西部DNA修复研讨会最初被设想为一个论坛，每年将来自中西部地区的DNA修复研究人员聚集在一起，讨论正在进行的研究并鼓励合作。DNA修复是维持基因组稳定和消除DNA损伤的关键过程，如果不修复，可能会导致基因组突变。DNA修复途径的中断与许多遗传性癌症以及大多数(如果不是全部)散发性癌症有关。了解这些DNA修复途径及其调控将对人类健康产生重大影响。AMDRS现已进入第二个十年，自成立以来，这一系列研讨会取得了极大的成功。在过去的几年里，出席人数有了显著的增长，每年都会培养新的合作伙伴。这一成功和出席人数增加的重要因素之一是使出席这次会议的费用保持在较低水平。为了实现这一目标，每年的组织者都在各自的机构举办研讨会，并确保获得内部和外部资金，以支付一些主要费用。AMDRS是一次会议，PI能够带着他们的整个实验室与该领域的领先科学家互动，并在同行中展示他们的工作。AMDRS的三个主要目标是：1)为主要来自中西部各州的科学家提供一个场所，介绍和讨论DNA损伤、修复和突变领域的当前研究，并提供促进科学合作的机会。(2)为学生、博士后研究员和初级独立研究人员提供机会，向同行介绍他们的工作，并与该领域的领导人互动。(3)通过让这些研讨会负担得起来提供额外的价值。 与公共卫生相关：DNA修复是由几个细胞过程组成的，这些过程移除受损的DNA进行修复。有效的DNA修复是预防癌症的基础，选择性地禁用DNA修复途径是抗癌化疗策略的关键。在一个集中在DNA修复领域的集中科学会议上传播研究成果是合作确定人类癌症的原因、诊断、预防和治疗的理想场所。

DESCRIPTION (provided by applicant): The 13th Annual Midwest DNA Repair Symposium (AMDRS) will take place in Toledo, OH on May 14 - 15, 2011 at the Dana Conference Center on the University of Toledo Health Science campus. The AMDRS started in 1999 at the University of Michigan and has been hosted at various universities across the Midwest every year since then. The Midwest DNA Repair Symposium was originally conceived as a forum to bring together DNA repair researchers from the Midwestern region on an annual basis to discuss ongoing research and to stimulate collaborations. DNA repair is a critical process to maintain genomic stability and remove DNA damage that if left unrepaired, could result in genomic mutations. Disruption of the DNA repair pathways has been linked to many inherited cancers as well as most, if not all sporadic cancers. Understanding these DNA repair pathways and their regulation will have a significant impact on human health. The AMDRS is now in its second decade, and since its inception, this symposia series has been extremely successful. Over the past several years, there have been significant increases in attendance and new collaborations are fostered each year. One of the important factors to this success and the increase in attendance has been to keep the costs of attending this meeting low. To achieve this goal, the organizers for each year hold the symposium at their home institutions and secure both intramural and extramural funding to cover some of the major expenses. The AMDRS is one meeting to which PI's have been able to bring their entire labs to interact with leading scientists in the field and to present their work among peers. The three principle goals of the AMDRS are: 1) to provide a venue for scientists mainly from the Midwestern states, to present and discuss current research in the field of DNA damage, repair and mutagenesis, and to provide opportunities to foster scientific collaborations. (2) To provide students, postdoctoral fellows, and beginning independent investigators the opportunity to present their work to peers and to interact with leaders in the field. (3) To provide an exceptional value of these symposia by keeping them affordable. PUBLIC HEALTH RELEVANCE: DNA repair is composed of several cellular processes that remove damaged DNA for repair. Efficient DNA repair is fundamental to the prevention of cancer, selectively disabling DNA repair pathways is essential for chemotherapeutic strategies against cancer. The dissemination of research findings at a centrally located scientific meeting that is highly focused within the field of DNA Repair is an ideal venue towards collaborative determination of the cause, diagnosis, prevention, and treatment of human cancer.