Functional near-infrared imaging using the phase of hemodynamic oscillations

使用血流动力学振荡相位的功能性近红外成像

• 批准号: 8094914
• 负责人: Angelo Sassaroli
• 金额: $ 7.45万
• 依托单位: TUFTS UNIVERSITY MEDFORD
• 依托单位国家: 美国
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-03-01 至 2013-01-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8094914
• 关键词: Affect; Area; Base of the Brain; Blood Vessels; Blood Volume; Brain; Brain imaging; Cerebrovascular Circulation; Cerebrum; Characteristics; Cognitive; Coupling; Data Analyses; Data Set; Dependence; Development; Frequencies; Functional Imaging; Functional Magnetic Resonance Imaging; Goals; Hemodynamic Processes; Hemoglobin; Homeostasis; Image; Imaging Device; Lead; Measurement; Measures; Metabolic; Metabolism; Methods; Near-Infrared Spectroscopy; Optics; Oxygen; Phase; Physiological Processes; Play; Polysomnography; Process; Protocols documentation; Relative (related person); Research; Rest; Role; Scalp structure; Sensory; Signal Transduction; Sleep; Sleep Stages; Source; Testing; Time; Tissues; base; brain tissue; cranium; detector; frontal lobe; hemodynamics; human subject; novel; novel strategies; response; somatosensory; visual motor

DESCRIPTION (provided by applicant): This project explores the potential of a novel approach to functional studies of the brain with near-infrared spectroscopy. We hypothesize that the phase relationship between oscillations of cerebral oxy-hemoglobin and deoxy-hemoglobin concentrations provide information about (1) the interplay of hemodynamic and oxygenation-related processes that are associated with brain activation, and (2) functional connectivity networks involving distinct cortical areas. Specifically, in this project we will perform a new analysis of data collected previously in a full-night sleep study using a novel phasor-based analysis and representation of hemodynamic oscillations. This new analysis will allow us to test the hypothesis that hemodynamic conditions associated with different sleep stages induce different phase relationship between spontaneous oscillations of oxy-hemoglobin and deoxy-hemoglobin concentrations at frequencies around 0.1 Hz (Mayer waves). We will also test the hypothesis that oxy-hemoglobin and deoxy-hemoglobin concentration changes have different relative phases depending on the cortical area activated and/or the stimulation protocol. Finally, we will perform pilot measurements to test the potential of this new phase-based method in studying functional connectivity networks in the brain. This project can lead to a novel approach to functional brain studies, and explores signals that are not accessible with functional magnetic resonance imaging, involving both paramagnetic and diamagnetic hemoglobin species. PUBLIC HEALTH RELEVANCE: We propose a novel approach to near-infrared functional imaging based on the phase of oscillations of oxy- and deoxy-hemoglobin tissue concentrations. This approach will provide information on the spatial and temporal interplay of hemodynamic and metabolic processes occurring in resting and activated states of the brain. Such information can play a critical role in advancing the understanding of neurovascular coupling, functional connectivity, and cerebral autoregulation, all critical aspects for the development of a significant functional imaging tool.

描述（由申请人提供）：本项目探讨了一种新的方法的潜力，近红外光谱的大脑功能研究。我们假设脑氧合血红蛋白和脱氧血红蛋白浓度振荡之间的相位关系提供了以下信息：（1）与脑激活相关的血流动力学和氧合相关过程的相互作用，以及（2）涉及不同皮质区域的功能连接网络。具体来说，在这个项目中，我们将使用一种新的基于相量的分析和血流动力学振荡的表示法，对以前在整晚睡眠研究中收集的数据进行新的分析。这种新的分析将使我们能够测试的假设，即与不同的睡眠阶段相关的血液动力学条件诱导氧合血红蛋白和脱氧血红蛋白浓度的自发振荡之间的不同的相位关系在0.1 Hz左右的频率（迈耶波）。我们还将测试氧合血红蛋白和脱氧血红蛋白浓度变化具有不同的相对相位的假设，这取决于激活的皮层区域和/或刺激方案。最后，我们将进行试点测量，以测试这种新的基于相位的方法在研究大脑功能连接网络中的潜力。该项目可能会导致一种新的方法来功能性大脑研究，并探讨信号是无法访问的功能性磁共振成像，涉及顺磁性和反磁性血红蛋白物种。 公共卫生相关性：我们提出了一种新的方法，近红外功能成像的基础上的氧和脱氧血红蛋白组织浓度的振荡的相位。这种方法将提供信息的空间和时间的相互作用的血流动力学和代谢过程中发生的休息和激活状态的大脑。这些信息可以在促进对神经血管耦合、功能连接和脑自动调节的理解方面发挥关键作用，这些都是重要功能成像工具开发的关键方面。