BRIDGES for Evaluation of Health Outcomes, Repercussions and Impacts in Zones of

评估健康结果、后果和影响的桥梁

• 批准号: 8133631
• 负责人: Kim A. Anderson
• 金额: $ 32.74万
• 依托单位: OREGON STATE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-11-22 至 2012-10-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8133631
• 关键词: Address; Affect; Air; Ames Assay; Aromatic Polycyclic Hydrocarbons; Bioavailable; Biological; Biological Assay; Biological Availability; Chemicals; Collaborations; Communities; Coupled; Data; Detection; Development; Devices; Diagnostic; Disasters; Embryo; Environmental Exposure; Environmental Health; Evaluation; Exposure to; Fingerprint; Florida; Generations; Goals; Grant; Health; Health Professional; Health education; Human; In Situ; Individual; Internet; Life; Louisiana; Measurement; Measures; Methods; Mexico; Modeling; Oils; Online Systems; Outcome; Pattern Recognition; Process; Public Health; Reaction; Relative (related person); Research Project Grants; Risk; Risk Assessment; Sampling; Site; Source; Superfund; System; Technology; Testing; Time; Toxic effect; Uncertainty; Water; Work; Zebrafish; analytical tool; chemical spill; environmental stressor; hazard; innovation; microbial; novel; organic contaminant; outreach; response; tool; zebrafish development

DESCRIPTION (provided by applicant): The goals of the proposed project will be to use passive samplers in the Gulf of Mexico before, during and post impact from the Deepwater Horizon Spill of 2010. The passive samplers are biological response indicator devices for gauging environmental stressors (BRIDGES) developed as part of a Superfund Center grant. The devices are air and water passive sampling devices (PSD) that bridge environmental exposure and biological response/effect. They can provide for high throughput samples and rapid turnaround of data. They sequester polycyclic aromatic hydrocarbons (PAHs), oxygenated PAHs (OPAHs) as well as other organic contaminants. OPAHs are potentially more mobile, bioavailable and/or persistent than PAHs. There is growing evidence that OPAHs have important toxicological significance. Dispersants that increase bioavailability coupled with sites exposed to UV may increase OPAHs. The use of complementary bioanalytical tools that quantify bioavailability PAH processes is important to understand disasters such as chemical spill risk. Specific Aim 1: Deploy a set of BRIDGES, air and water bio-analytical tools, regionally in the Gulf of Mexico before, during and post impact to quantitatively sequester bioavailable contaminants. Specific Aim 2: Develop discriminatory pattern recognition and multivariate regression assessments of components in PSD extracts and contaminant source type. Specific Aim 3: Utilize the zebrafish developmental model and Ames assay to test the relative potency of pre-, during and post-impact Deepwater Horizon spill BRIDGES extracts. From a translational perspective, a significant data gap currently exists with respect to oxygenated PAHs and the risk assessment process, currently only the 16 priority PAHs in air is EPA's focus. OPAHs are known to be important hazards, the detection and quantification will provide new and very important information on the complexity of the spill that is not currently being captured. The Outreach, in collaboration, will relate environmental health education that applies to the Gulf of Mexico Oil Spill research of the Project and disseminate to individuals working and living in the states along the coastline of the Gulf of Mexico using novel methods including the web. PUBLIC HEALTH RELEVANCE: Rapid generation of high throughput bioavailable PAHs data in air and water from the Deepwater Horizon Spill in LA, MS, AL, and FL will have standalone value. First creation of bioavailable oxygenated PAH data will be invaluable to understanding effects on environmental and human health. Providing pertinent PAH health information to be delivered using novel methods via the web will fill identified information gaps needed by community leaders, and public health professionals.

描述（由申请人提供）：拟议项目的目标是在2010年深水地平线泄漏影响之前、期间和之后在墨西哥湾使用被动采样器。被动采样器是作为超级基金中心赠款的一部分开发的用于测量环境压力源（桥梁）的生物反应指示器设备。这些设备是空气和水被动采样设备（PSD），连接环境暴露和生物反应/效应。它们可以提供高通量样品和快速的数据周转。它们螯合多环芳烃（PAH）、含氧多环芳烃（OPAH）以及其他有机污染物。OPAH比PAH具有更大的潜在移动的、生物可利用性和/或持久性。越来越多的证据表明OPAHs具有重要的毒理学意义。增加生物利用度的分散剂加上暴露于紫外线的位点可能会增加OPAH。使用互补的生物分析工具，量化生物利用度多环芳烃的过程是很重要的，以了解灾害，如化学品泄漏的风险。具体目标1：在影响之前、期间和之后，在墨西哥湾区域部署一套桥梁、空气和水生物分析工具，以定量隔离生物可利用的污染物。具体目标二：开发PSD提取物和污染源类型中组分的判别模式识别和多元回归评估。具体目标3：利用斑马鱼发育模型和艾姆斯试验来测试撞击前、撞击期间和撞击后深水地平线泄漏BRIDGES浸提液的相对效力。从转化的角度来看，一个显着的数据差距，目前存在的含氧多环芳烃和风险评估过程，目前只有16个优先多环芳烃在空气中是EPA的重点。已知OPAH是重要的危害，检测和定量将提供关于目前尚未捕获的泄漏复杂性的新的和非常重要的信息。外联方案将与该项目合作，将适用于墨西哥湾漏油研究的环境卫生教育联系起来，并使用包括网络在内的新方法向在墨西哥湾沿着各州工作和生活的个人传播。 公共卫生关系：从洛杉矶、密西西比州、阿拉巴马州和佛罗里达州的深水地平线泄漏事故中快速生成空气和水中的高通量生物可利用多环芳烃数据将具有独立价值。首次建立生物可利用的含氧多环芳烃数据对于了解其对环境和人类健康的影响将是非常宝贵的。通过网络使用新方法提供相关的PAH健康信息，将填补社区领导人和公共卫生专业人员所需的已确定的信息空白。