Personal Envl Exposure Assmt using Wristbands for Epi Studies in Disadv Comm

描述(由申请人提供)：准确评估一个人对假定的环境毒物的暴露是研究环境健康影响的核心挑战。缺乏低成本、易于使用的个人抽样技术阻碍了流行病学研究，特别是在弱势人群中。我们的被动式腕带采样器是为了提供相关的、可量化的评估而开发的。我们建议引入一种改进的方法来测量和表征弱势社区中的多环芳烃(PAHs)。在第一阶段(R21)，在纽约市正在进行的一项针对孕妇的流行病学队列研究中，将对从曼哈顿北部一家社区卫生诊所招募的25名怀孕志愿者进行4种暴露评估方法的性能评估。在与501C3环境正义社区组织的合作下，我们进一步将被动腕带采样器改进为集成的移动曝光设备，以捕获俄勒冈州尤金工业化社区的独特链接暴露和健康信息。在完成第一阶段里程碑后，我们将进一步评估个人暴露测量与纽约市儿童呼吸道症状和尤金成人哮喘恶化的流行病学研究的整合，以评估这些弱势社区空气污染物、地点和健康结果之间的关系。通过这个项目的R33阶段，我们将提供原则证明，被动腕带采样器可以用于个性化暴露评估和与健康结果的联系。数据和结果将通过新颖和适当的数据可视化提供给我们的参与者和他们的社区。

DESCRIPTION (provided by applicant): Accurately assessing a person's exposures to putative environmental toxicants is central to the challenge of studying environmental health effects. The lack of low cost, easy-to-use personal sampling technology hinders epidemiological studies especially in disadvantaged populations. Our passive wristband sampler was developed to provide a relevant, quantifiable assessment. We propose to introduce an improved approach for measuring and characterizing polycyclic aromatic hydrocarbons (PAHs) in disadvantaged communities. In phase 1 (R21), in an ongoing epidemiological cohort study of pregnant women in NYC, the performance of 4 exposure assessment methodologies will be evaluated with twenty-five pregnant volunteers recruited from a community health clinic located in northern Manhattan. In collaboration with a 501c3 environmental justice community organization, we have further advanced the passive wristband sampler to be an integrated mobile exposure device to capture uniquely-linked exposure and health information in their industrialized neighborhood in Eugene, Oregon. Upon completion of Phase 1 milestones, we will further assess the integration of personal exposure measurements with epidemiology studies of childhood respiratory symptoms in NYC and adult asthma exacerbation in Eugene to assess the relationships between air pollutants, location, and health outcomes in these disadvantaged communities. Through the R33 phase of this project, we will provide proof of principle demonstration that passive wristband samplers can be used for personalized exposure assessment and linkage to health outcomes. Data and results will be made available to our participants and their communities through novel and appropriate data visualization.