Personal Envl Exposure Assmt using Wristbands for Epi Studies in Disadv Comm

使用腕带进行个人环境暴露测试以进行不良通讯中的 Epi 研究

• 批准号: 9250773
• 负责人: Kim A. Anderson
• 金额: $ 61.66万
• 依托单位: OREGON STATE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2016
• 资助国家: 美国
• 起止时间: 2016-04-01 至 2020-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9250773
• 关键词: Adult asthma; Air; Air Pollutants; Air Pollution; Analytical Chemistry; Aromatic Polycyclic Hydrocarbons; Asthma; Biological Markers; Biological Monitoring; Birth; Car Phone; Cellular Phone; Chemical Exposure; Chemicals; Child; Childhood; Chronic; Clinic; Clinical; Cohort Studies; Collaborations; Communities; Community Health; Data; Devices; Disadvantaged; Disease; Environmental Exposure; Environmental Health; Epidemiology; Etiology; Exposure to; Future; Health; Human; Hypersensitivity; Individual; Industrialization; Link; Location; Logistics; Measurement; Measures; Methodology; Methods; Monitor; Neighborhoods; New York City; Obesity; Oregon; Outcome; Participant; Performance; Persons; Phase; Pregnancy Trimesters; Pregnant Women; Questionnaires; Recruitment Activity; Research; Research Personnel; Respiratory Signs and Symptoms; Respiratory physiology; Role; Sampling; Seasons; Spirometry; Stream; Symptoms; Techniques; Technology; Testing; Time; Toxic Environmental Substances; Universities; Urine; Woman; absorption; air monitoring; base; cancer risk; carcinogenicity; cohort; community organizations; cost; data visualization; disadvantaged population; early childhood; environmental chemical; environmental justice; epidemiology study; improved; innovation; light weight; member; neighborhood disadvantage; neurodevelopment; novel; pregnant; prenatal; public health relevance; respiratory health; urinary; volunteer

DESCRIPTION (provided by applicant): Accurately assessing a person's exposures to putative environmental toxicants is central to the challenge of studying environmental health effects. The lack of low cost, easy-to-use personal sampling technology hinders epidemiological studies especially in disadvantaged populations. Our passive wristband sampler was developed to provide a relevant, quantifiable assessment. We propose to introduce an improved approach for measuring and characterizing polycyclic aromatic hydrocarbons (PAHs) in disadvantaged communities. In phase 1 (R21), in an ongoing epidemiological cohort study of pregnant women in NYC, the performance of 4 exposure assessment methodologies will be evaluated with twenty-five pregnant volunteers recruited from a community health clinic located in northern Manhattan. In collaboration with a 501c3 environmental justice community organization, we have further advanced the passive wristband sampler to be an integrated mobile exposure device to capture uniquely-linked exposure and health information in their industrialized neighborhood in Eugene, Oregon. Upon completion of Phase 1 milestones, we will further assess the integration of personal exposure measurements with epidemiology studies of childhood respiratory symptoms in NYC and adult asthma exacerbation in Eugene to assess the relationships between air pollutants, location, and health outcomes in these disadvantaged communities. Through the R33 phase of this project, we will provide proof of principle demonstration that passive wristband samplers can be used for personalized exposure assessment and linkage to health outcomes. Data and results will be made available to our participants and their communities through novel and appropriate data visualization.

描述（由申请人提供）：准确评估一个人对假定的环境毒物的暴露是研究环境健康影响的核心挑战。缺乏低成本、易于使用的个人抽样技术阻碍了流行病学研究，特别是在弱势群体中。我们的被动腕带采样器的开发是为了提供相关的，可量化的评估。我们提出了一种改进的方法来测量和表征弱势社区的多环芳烃（PAHs）。在第一阶段（R21）中，在一项正在进行的纽约市孕妇流行病学队列研究中，将对从曼哈顿北部一家社区卫生诊所招募的25名孕妇志愿者进行4种暴露评估方法的评估。通过与501c3环境正义社区组织合作，我们进一步改进了被动式腕带采样器，使其成为一种集成的移动暴露设备，以捕获俄勒冈州尤金市工业化社区中独特的暴露和健康信息。在完成第一阶段里程碑后，我们将进一步评估个人暴露测量与纽约市儿童呼吸道症状和尤金成人哮喘加重的流行病学研究的整合，以评估这些弱势社区空气污染物、地点和健康结果之间的关系。通过该项目的R33阶段，我们将提供原理证明，即被动式腕带采样器可用于个性化暴露评估并与健康结果相关联。数据和结果将通过新颖和适当的数据可视化提供给我们的参与者和他们的社区。