Multi-level optimization of membrane proteins for crystallography

用于晶体学的膜蛋白的多级优化

• 批准号: 8152512
• 负责人: MICHAEL G MALKOWSKI
• 金额: $ 80.53万
• 依托单位: HAUPTMAN-WOODWARD MEDICAL RESEARCH INST
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-09-30 至 2015-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8152512
• 关键词: Affect; Automation; Behavior; Benign; Bile Acids; Binding; Biochemical; Biological; Biological Assay; Calorimetry; Carbon Dioxide; Cell Maintenance; Cell physiology; Cells; Chemicals; Cloning; Cocrystallography; Codon Nucleotides; Collaborations; Communities; Community Outreach; Complex; Crystallization; Crystallography; Detergents; Development; Disease; Drug Design; Endocannabinoids; Engineering; Enzymes; Erythrocytes; Escherichia coli; Family; Flow Cytometry; Fluorescent Probes; G-Protein-Coupled Receptors; Gel Chromatography; Genes; Heterogeneity; Homeostasis; Human; Human Resources; Insecta; Institutes; Instruction; Integral Membrane Protein; Ion Transport; Ions; Knowledge; Label; Laboratories; Libraries; Ligands; Lipids; Mammals; Measurement; Mediating; Medical; Membrane; Membrane Proteins; Molecular; Molecular Conformation; Molecular Structure; Mutate; Nutrient; Oils; Oligopeptides; Organism; Orthologous Gene; Oxygen; Pharmaceutical Preparations; Phase; Physiology; Play; Post-Translational Protein Processing; Procedures; Process; Production; Property; Protein Family; Proteins; Proteolysis; Protocols documentation; Publishing; Reagent; Recording of previous events; Refractive Indices; Research Infrastructure; Research Personnel; Role; Screening procedure; Signal Transduction; Solubility; Solutions; Solvents; Sphingolipids; Structure; System; Techniques; Technology; Testing; Thermodynamics; Time; Titrations; Transmembrane Transport; Ursidae Family; Validation; Work; Yeasts; base; design; high throughput screening; improved; interest; light scattering; member; novel strategies; pH Homeostasis; prenyl; protein S precursor; protein complex; protein function; protein structure; receptor function; structural biology; structural genomics; success; technology development; three dimensional structure; uptake; yeast genetics