Substance Use and Psychological Problems Among African Americans into Midlife

描述（由申请人提供）：国家数据表明，物质使用和心理问题在中年非洲裔美国人中变得更加明显，但很少有研究研究探讨非洲裔美国人社区中这些问题的风险发展，特别是进入成年中期。此外，高并发率要求探索独特和共同的风险因素的方法;然而，这些问题很少一起研究。应用发展的角度来看，我们的目标是检查特定的风险，保护，调解和调节因素，影响以后的物质使用和心理问题之间的社区为基础的非裔美国人人口纵向跟踪。此外，非常需要确定物质使用和心理问题如何导致成年中期的身体健康下降。Woodlawn研究是一项对非裔美国人社区队列进行的流行病学前瞻性研究，涵盖了超过35年的生命，为了解风险和保护因素以及药物使用和治疗范围外心理问题的短期和长期后果提供了广泛的数据。随着数据延伸到中年-生命过程中被忽视的一个方面-可以在研究不足的人群中确定早期风险因素和关键的中介和调节影响。该队列最初在1966- 1967年作为一年级学生（N=1242）进行评估，并在青春期（15-16岁），成年早期（32-33岁）和成年中期（42-43岁）进行随访，创造了一个前所未有的个人，家庭和环境特征，多样化的生命历程经历及其最终后果的编年史。在生命历程社会场理论的指导下，该研究侧重于：物质使用和障碍的发展流行病学和心理问题，通过中年，确定发病，持续，缓解，共同发生和相互影响;儿童和青少年成人物质使用和障碍的风险因素和心理问题;对早期风险因素的中介和调节影响;和成年后的身体健康后果。分析方法包括结构方程模型，倾向得分匹配，一般增长混合模型，潜在类，生存和聚类分析。对药物使用和心理问题风险发展的时间和机制的进一步理解将为设计有效的预防和干预方案提供必要的指导。公共卫生相关性：项目叙述/公共卫生意义本项目的公共卫生相关性是告知预防和干预计划的设计，以预防和干预非裔美国人到中年的物质使用和心理问题。该项目还将提供关键的洞察城市非洲裔美国人在成年中期的身体健康问题，确定精神病理学对特定健康问题的贡献。

DESCRIPTION (provided by applicant): National data indicate that both substance use and psychological problems become more pronounced for African Americans in midlife, but few studies have examined the development of risk for these problems in African American communities, particularly into mid adulthood. Moreover, high rates of co-occurrence demand an approach that explores both unique and shared risk factors; however, these problems rarely have been studied together. Applying a developmental perspective, we aim to examine specific risk, protective, mediating, and moderating factors that influence later substance use and psychological problems among a community- based African American population followed longitudinally. In addition, there is a great need to determine how substance use and psychological problems contribute to physical health decline in mid adulthood. Spanning more than 35 years of life, the Woodlawn Study, an epidemiological, prospective study of an African American community cohort, provides extensive data for understanding risk and protective factors and the short- and long-term consequences of substance use and psychological problems outside the context of treatment. With data extending into midlife - a neglected dimension of the life course - early risk factors and key mediating and moderating influences can be identified in an understudied population. This cohort was assessed initially as first graders in 1966-67 (N=1242), and followed up in adolescence (age 15-16), early adulthood (age 32-33), and mid-adulthood (age 42-43), creating an unprecedented chronicle of individual, family, and environmental characteristics, diverse life-course experiences, and their ultimate consequences. Guided by the Life Course Social Field Theory, the study focuses on: the developmental epidemiology of substance use and disorders and psychological problems through midlife, identifying onset, persistence, remission, co-occurrence, and reciprocal effects; childhood and adolescent risk factors for adult substance use and disorders and psychological problems; mediating and moderating influences on early risk factors; and physical health consequences in adulthood. Analytic methods include structural equation modeling, propensity score matching, general growth mixture modeling, and latent class, survival, and cluster analyses. Improved understanding of the timing and mechanisms for development of risk for substance use and psychological problems will provide essential guidance in designing effective prevention and intervention programs. PUBLIC HEALTH RELEVANCE: PROJECT NARRATIVE/PUBLIC HEALTH SIGNIFICANCE The public health relevance of this project is to inform the design of prevention and intervention programs for substance use and psychological problems among African Americans into midlife. The project will also provide critical insight into physical health problems of urban African Americans during mid-adulthood, identifying the contribution of psychopathology to specific health problems.