Aging and Perceptual Learning: Behavioral and fMRI Studies

衰老和知觉学习：行为和功能磁共振成像研究

• 批准号: 8037495
• 负责人: George J Andersen
• 金额: $ 16.4万
• 依托单位: UNIVERSITY OF CALIFORNIA RIVERSIDE
• 依托单位国家: 美国
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-09-15 至 2011-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8037495
• 关键词: Accidents; Address; Age; Aging; Area; Attention; Automobile Driving; Behavioral; Behavioral Research; Brain; Cataract; Contrast Sensitivity; Dark Adaptation; Detection; Discrimination; Disease; Elderly; Functional Magnetic Resonance Imaging; Funding; Glaucoma; Grant; Individual; Injury; Intervention; Literature; Location; Macular degeneration; Methodology; Modeling; Motion; Motion Perception; Nature; Neurons; Noise; Optics; Participant; Perception; Perceptual learning; Performance; Process Measure; Psychological Transfer; Recovery; Request for Proposals; Research; Risk; Role; Sensory; Sensory Process; Shapes; Specificity; Staging; Stimulus; Surface; Testing; Training; United States National Institutes of Health; Vision; Visual; Visual Acuity; Visual Fields; Visual Perception; age related; behavioral/social science; falls; improved; neural recruitment; normal aging; older driver; parent grant; public health relevance; research study; response; spatial vision; theories; visual process; visual processing

DESCRIPTION (provided by applicant): The proposed research is in response to NOT-OD-10-032 ("NIH announces the availability of recovery act funds for competitive revision applications through the NIH Basic and Behavioral and Social Science Opportunity Network (OppNet). A well documented finding in the literature is that visual perception declines with age. These declines include the perception of target orientation, low contrast stimuli, motion, shape and form. Age related declines in visual processing have been implicated as a leading cause of falls among the elderly as well as the increased risk of accidents for older drivers. The proposed revision will include research that will examine two distinct and new areas of inquiry not addressed in the parent grant. The first study will test predictions from a formal model of perceptual learning (the perceptual template model proposed by Lu and Dosher, 1999; 2008). The experiment will determine, using drifting or moving Gabor patches, whether PL among older subjects results in changes in internal noise, changes in sensitivity to external noise, or changes in multiplicative noise. A second study will extend the results of the first experiment to motion stimuli using random dot cinematograms. The third study will examine whether PL changes in sensory processing for older subjects are the result of changes in center-surround inhibition. This issue will be examined by conducting an experiment using stimuli that has been previously used to demonstrate reduced center-surround inhibition among older observers, and determining whether this age-related effect changes as a function of PL. PUBLIC HEALTH RELEVANCE: The proposed research will examine how training with visual displays can be used to improve visual perception for older individuals. The studies will include behavioral research to determine how perception improves and how the improvement is related to changes in brain activity. PUBLIC HEALTH RELEVANCE: The proposed research will examine how training with visual displays can be used to improve visual perception for older individuals. The studies will include behavioral research to determine how perception improves and how the improvement is related to changes in brain activity.

描述（由申请人提供）：拟议的研究是为了响应NOT-OD-10-032（“NIH宣布通过NIH基本和行为与社会科学机会网络（OppNet）为竞争性修订申请提供恢复法案资金。文献中有一个有据可查的发现是，视知觉随着年龄的增长而下降。这些下降包括对目标方向、低对比度刺激、运动、形状和形式的感知。与年龄相关的视觉处理能力下降被认为是老年人福尔斯摔倒的主要原因，也是老年驾驶员发生事故的风险增加的主要原因。拟议的修订将包括研究，将审查两个不同的和新的调查领域没有解决的母赠款。第一项研究将测试感知学习的正式模型（由Lu和Dosher提出的感知模板模型，1999; 2008）的预测。该实验将使用漂移或移动的Gabor贴片来确定老年受试者中的PL是否会导致内部噪声的变化、对外部噪声的敏感性的变化或乘性噪声的变化。第二项研究将第一个实验的结果扩展到使用随机点电影的运动刺激。第三项研究将探讨是否PL的变化，在感觉处理的老年人的结果，在中心-环绕抑制的变化。这个问题将通过使用先前用于证明老年观察者中中心-环绕抑制降低的刺激进行实验来研究，并确定这种与年龄相关的效应是否随PL而变化。公共卫生相关性：拟议的研究将研究如何使用视觉显示器进行训练，以改善老年人的视觉感知。这些研究将包括行为研究，以确定感知如何改善以及这种改善如何与大脑活动的变化相关。 公共卫生关系：拟议的研究将研究如何使用视觉显示器进行训练，以改善老年人的视觉感知。这些研究将包括行为研究，以确定感知如何改善以及这种改善如何与大脑活动的变化相关。