Aging and Perceptual Learning: Behavioral and fMRI Studies

衰老和知觉学习:行为和功能磁共振成像研究

基本信息

  • 批准号:
    8529415
  • 负责人:
  • 金额:
    $ 55.06万
  • 依托单位:
  • 依托单位国家:
    美国
  • 项目类别:
  • 财政年份:
    2009
  • 资助国家:
    美国
  • 起止时间:
    2009-09-15 至 2016-08-31
  • 项目状态:
    已结题

项目摘要

DESCRIPTION (provided by applicant): A well documented finding in the literature is that visual perception declines with age. These declines include the perception of target orientation, low contrast stimuli, motion, shape and form. Age related declines in visual processing have been implicated as a leading cause of falls among the elderly as well as the increased risk of accidents for older drivers. The purpose of this research is to examine whether perceptual learning with sub threshold stimuli can be used to recover age-related declines in visual perception. The proposed research will include behavioral studies and fMRI studies. The proposed behavioral experiments will determine whether the improved performance for older observers via perceptual learning is due to changes in early stage visual processing, later stages of visual processing, or non-sensory processing. The effects of perceptual learning and the locus of improvement will be assessed by examining location and interocular transfer and by assessing transfer of training from perceptual tasks associated at the same stage of processing (e.g., orientation and contrast) as well as different stages of processing (e.g., global motion and orientation). The impact of perceptual learning on non-sensory processing will be assessed by examining changes in response criteria and improvements in divided attention. fMRI studies will examine whether the improved behavioral performance from perceptual learning for older observers is due to functional plasticity, neural recruitment, or changes in hemispheric asymmetry of activation. The fMRI studies will examine the same perceptual learning tasks that will be examined in the behavioral studies and will examine changes in activation in several regions in visual cortex as well as prefrontal cortex. In addition, contingent on the results of the behavioral and fMRI studies we plan on conducting structural imaging studies to determine whether perceptual learning results in physiological changes in neuronal systems. Finally, we also plan on conducting intervention studies to determine whether improved performance for older observers via perceptual learning can improve performance in driving related tasks. The goal of this line of research is to examine whether recovery of visual function using perceptual learning can be applied to situations known to be of importance for the safety, well being and quality of life of older populations. PUBLIC HEALTH RELEVANCE: The proposed research will examine how training with visual displays can be used to improve visual perception for older individuals. The studies will include behavioral research and brain imaging research to determine how perception improves and how the improvement is related to changes in brain activity.
描述(由申请人提供):文献中有一个有充分证据的发现,即视觉知觉随着年龄的增长而下降。这些下降包括对目标方向、低对比度刺激、运动、形状和形状的感知。与年龄相关的视觉处理能力下降被认为是老年人跌倒的主要原因,也是老年司机发生事故的风险增加的原因。本研究的目的是检验使用阈值以下刺激的知觉学习是否可以用来恢复与年龄相关的视觉知觉下降。拟议的研究将包括行为研究和功能磁共振研究。拟议的行为实验将确定老年观察者通过知觉学习而提高的表现是由于早期视觉加工、后期视觉加工还是非感觉加工的变化。感知学习的效果和改进的中心将通过检查位置和眼间转移,以及通过评估在同一加工阶段(例如,定向和对比度)以及不同加工阶段(例如,全局运动和定向)相关的知觉任务的训练转移来评估。感知学习对非感官加工的影响将通过检查反应标准的变化和分散注意力的改善来评估。FMRI研究将检验老年观察者知觉学习行为表现的改善是由于功能可塑性、神经招募,还是由于大脑半球激活不对称的变化。功能磁共振成像研究将检查与行为研究相同的知觉学习任务,并将检查视觉皮质和前额叶皮质几个区域的激活变化。此外,根据行为和功能磁共振研究的结果,我们计划进行结构成像研究,以确定知觉学习是否会导致神经系统的生理变化。最后,我们还计划进行干预研究,以确定通过知觉学习提高老年观察者的表现是否可以改善驾驶相关任务的表现。这一系列研究的目的是检验利用知觉学习恢复视觉功能是否可以应用于已知对老年人的安全、福祉和生活质量具有重要意义的情况。公共卫生相关性:这项拟议的研究将研究如何使用视觉显示培训来改善老年人的视觉感知。这些研究将包括行为研究和大脑成像研究,以确定知觉如何改善,以及这种改善与大脑活动的变化如何相关。

项目成果

期刊论文数量(3)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
Behavioral training to improve collision detection.
  • DOI:
    10.1167/15.10.2
  • 发表时间:
    2015-07
  • 期刊:
  • 影响因子:
    1.8
  • 作者:
    D. DeLoss;Zheng Bian;Takeo Watanabe;G. Andersen
  • 通讯作者:
    D. DeLoss;Zheng Bian;Takeo Watanabe;G. Andersen
Aging, Spatial Disparity, and the Sound-Induced Flash Illusion.
  • DOI:
    10.1371/journal.pone.0143773
  • 发表时间:
    2015
  • 期刊:
  • 影响因子:
    3.7
  • 作者:
    DeLoss DJ;Andersen GJ
  • 通讯作者:
    Andersen GJ
{{ item.title }}
{{ item.translation_title }}
  • DOI:
    {{ item.doi }}
  • 发表时间:
    {{ item.publish_year }}
  • 期刊:
  • 影响因子:
    {{ item.factor }}
  • 作者:
    {{ item.authors }}
  • 通讯作者:
    {{ item.author }}

数据更新时间:{{ journalArticles.updateTime }}

{{ item.title }}
  • 作者:
    {{ item.author }}

数据更新时间:{{ monograph.updateTime }}

{{ item.title }}
  • 作者:
    {{ item.author }}

数据更新时间:{{ sciAawards.updateTime }}

{{ item.title }}
  • 作者:
    {{ item.author }}

数据更新时间:{{ conferencePapers.updateTime }}

{{ item.title }}
  • 作者:
    {{ item.author }}

数据更新时间:{{ patent.updateTime }}

George J Andersen其他文献

George J Andersen的其他文献

{{ item.title }}
{{ item.translation_title }}
  • DOI:
    {{ item.doi }}
  • 发表时间:
    {{ item.publish_year }}
  • 期刊:
  • 影响因子:
    {{ item.factor }}
  • 作者:
    {{ item.authors }}
  • 通讯作者:
    {{ item.author }}

{{ truncateString('George J Andersen', 18)}}的其他基金

Aging and Perceptual Learning: Behavioral and fMRI Studies
衰老和知觉学习:行为和功能磁共振成像研究
  • 批准号:
    7650837
  • 财政年份:
    2009
  • 资助金额:
    $ 55.06万
  • 项目类别:
Aging and Perceptual Learning: Behavioral and fMRI Studies
衰老和知觉学习:行为和功能磁共振成像研究
  • 批准号:
    8319500
  • 财政年份:
    2009
  • 资助金额:
    $ 55.06万
  • 项目类别:
Aging and Perceptual Learning: Behavioral and fMRI Studies
衰老和知觉学习:行为和功能磁共振成像研究
  • 批准号:
    8130624
  • 财政年份:
    2009
  • 资助金额:
    $ 55.06万
  • 项目类别:
Aging and Perceptual Learning: Behavioral and fMRI Studies
衰老和知觉学习:行为和功能磁共振成像研究
  • 批准号:
    8037495
  • 财政年份:
    2009
  • 资助金额:
    $ 55.06万
  • 项目类别:
Perception of Object Motion from Optical, Binocular and Scene Information
从光学、双目和场景信息感知物体运动
  • 批准号:
    7924312
  • 财政年份:
    2009
  • 资助金额:
    $ 55.06万
  • 项目类别:
Aging and Perceptual Learning: Behavioral and fMRI Studies
衰老和知觉学习:行为和功能磁共振成像研究
  • 批准号:
    7930546
  • 财政年份:
    2009
  • 资助金额:
    $ 55.06万
  • 项目类别:
Perception of Object Motion from Optical, Binocular and Scene Information
从光学、双目和场景信息感知物体运动
  • 批准号:
    7669120
  • 财政年份:
    2007
  • 资助金额:
    $ 55.06万
  • 项目类别:
Perception of Object Motion from Optical, Binocular and Scene Information
从光学、双目和场景信息感知物体运动
  • 批准号:
    7500153
  • 财政年份:
    2007
  • 资助金额:
    $ 55.06万
  • 项目类别:
Perception of Object Motion from Optical, Binocular and Scene Information
从光学、双目和场景信息感知物体运动
  • 批准号:
    7297349
  • 财政年份:
    2007
  • 资助金额:
    $ 55.06万
  • 项目类别:
Perception of Object Motion from Optical, Binocular and Scene Information
从光学、双目和场景信息感知物体运动
  • 批准号:
    8139770
  • 财政年份:
    2007
  • 资助金额:
    $ 55.06万
  • 项目类别:

相似国自然基金

靶向递送一氧化碳调控AGE-RAGE级联反应促进糖尿病创面愈合研究
  • 批准号:
    JCZRQN202500010
  • 批准年份:
    2025
  • 资助金额:
    0.0 万元
  • 项目类别:
    省市级项目
对香豆酸抑制AGE-RAGE-Ang-1通路改善海马血管生成障碍发挥抗阿尔兹海默病作用
  • 批准号:
    2025JJ70209
  • 批准年份:
    2025
  • 资助金额:
    0.0 万元
  • 项目类别:
    省市级项目
AGE-RAGE通路调控慢性胰腺炎纤维化进程的作用及分子机制
  • 批准号:
  • 批准年份:
    2024
  • 资助金额:
    0 万元
  • 项目类别:
    面上项目
甜茶抑制AGE-RAGE通路增强突触可塑性改善小鼠抑郁样行为
  • 批准号:
    2023JJ50274
  • 批准年份:
    2023
  • 资助金额:
    0.0 万元
  • 项目类别:
    省市级项目
蒙药额尔敦-乌日勒基础方调控AGE-RAGE信号通路改善术后认知功能障碍研究
  • 批准号:
  • 批准年份:
    2022
  • 资助金额:
    33 万元
  • 项目类别:
    地区科学基金项目
LncRNA GAS5在2型糖尿病动脉粥样硬化中对AGE-RAGE 信号通路上相关基因的调控作用及机制研究
  • 批准号:
    n/a
  • 批准年份:
    2022
  • 资助金额:
    10.0 万元
  • 项目类别:
    省市级项目
围绕GLP1-Arginine-AGE/RAGE轴构建探针组学方法探索大柴胡汤异病同治的效应机制
  • 批准号:
    81973577
  • 批准年份:
    2019
  • 资助金额:
    55.0 万元
  • 项目类别:
    面上项目
AGE/RAGE通路microRNA编码基因多态性与2型糖尿病并发冠心病的关联研究
  • 批准号:
    81602908
  • 批准年份:
    2016
  • 资助金额:
    18.0 万元
  • 项目类别:
    青年科学基金项目
高血糖激活滑膜AGE-RAGE-PKC轴致骨关节炎易感的机制研究
  • 批准号:
    81501928
  • 批准年份:
    2015
  • 资助金额:
    18.0 万元
  • 项目类别:
    青年科学基金项目

相似海外基金

The Phenomenon of Stem Cell Aging according to Methylation Estimates of Age After Hematopoietic Stem Cell Transplantation
根据造血干细胞移植后甲基化年龄估算干细胞衰老现象
  • 批准号:
    23K07844
  • 财政年份:
    2023
  • 资助金额:
    $ 55.06万
  • 项目类别:
    Grant-in-Aid for Scientific Research (C)
Analysis of Age-dependent Functional Changes in Skeletal Muscle CB1 Receptors by an in Vitro Model of Aging-related Muscle Atrophy
通过衰老相关性肌肉萎缩的体外模型分析骨骼肌 CB1 受体的年龄依赖性功能变化
  • 批准号:
    22KJ2960
  • 财政年份:
    2023
  • 资助金额:
    $ 55.06万
  • 项目类别:
    Grant-in-Aid for JSPS Fellows
Joint U.S.-Japan Measures for Aging and Dementia Derived from the Prevention of Age-Related and Noise-induced Hearing Loss
美日针对预防与年龄相关和噪声引起的听力损失而导致的老龄化和痴呆症联合措施
  • 批准号:
    23KK0156
  • 财政年份:
    2023
  • 资助金额:
    $ 55.06万
  • 项目类别:
    Fund for the Promotion of Joint International Research (International Collaborative Research)
The Effects of Muscle Fatigability on Gait Instability in Aging and Age-Related Falls Risk
肌肉疲劳对衰老步态不稳定性和年龄相关跌倒风险的影响
  • 批准号:
    10677409
  • 财政年份:
    2023
  • 资助金额:
    $ 55.06万
  • 项目类别:
Characterizing gut physiology by age, frailty, and sex: assessing the role of the aging gut in "inflamm-aging"
按年龄、虚弱和性别表征肠道生理学特征:评估衰老肠道在“炎症衰老”中的作用
  • 批准号:
    497927
  • 财政年份:
    2023
  • 资助金额:
    $ 55.06万
  • 项目类别:
Deciphering the role of osteopontin in the aging eye and age-related macular degeneration
破译骨桥蛋白在眼睛老化和年龄相关性黄斑变性中的作用
  • 批准号:
    10679287
  • 财政年份:
    2023
  • 资助金额:
    $ 55.06万
  • 项目类别:
Role of AGE/RAGEsignaling as a driver of pathological aging in the brain
AGE/RAGE信号传导作为大脑病理性衰老驱动因素的作用
  • 批准号:
    10836835
  • 财政年份:
    2023
  • 资助金额:
    $ 55.06万
  • 项目类别:
Elucidation of the protein kinase NLK-mediated aging mechanisms and treatment of age-related diseases
阐明蛋白激酶NLK介导的衰老机制及年龄相关疾病的治疗
  • 批准号:
    23K06378
  • 财政年份:
    2023
  • 资助金额:
    $ 55.06万
  • 项目类别:
    Grant-in-Aid for Scientific Research (C)
Underlying mechanisms of age-related changes in ingestive behaviors: From the perspective of the aging brain and deterioration of the gustatory system.
与年龄相关的摄入行为变化的潜在机制:从大脑老化和味觉系统退化的角度来看。
  • 批准号:
    23K10845
  • 财政年份:
    2023
  • 资助金额:
    $ 55.06万
  • 项目类别:
    Grant-in-Aid for Scientific Research (C)
Targeting Age-Activated Proinflammatory Chemokine Signaling by CCL2/11 to Enhance Skeletal Muscle Regeneration in Aging
通过 CCL2/11 靶向年龄激活的促炎趋化因子信号传导以增强衰老过程中的骨骼肌再生
  • 批准号:
    478877
  • 财政年份:
    2023
  • 资助金额:
    $ 55.06万
  • 项目类别:
    Operating Grants
{{ showInfoDetail.title }}

作者:{{ showInfoDetail.author }}

知道了